PubMed Health⌕ Search

Biomedical subjects

M Akizuki

Publications and source records attributed to M Akizuki.

At least 109 records · Page 6Linked to original sources
PubMed1989

[A case of ankylosing spondylitis complicating Crohn's disease].

A 20-year-old man, who had suffered from ankylosing spondylitis for about 1 year, was admitted to our hospital due to melena and syncope. Physical examination revealed tenderness of abdomen and sacroiliac joint, and decreased spinal mobility. X-ray examination showed sacroiliitis and squaring of vertebral bodies. RA test and RAHA, negative; CRP, strongly positive; HLA-B 27 positive. Intestinal barium enema revealed skipping longitudinal fissure at terminal ileum, and a biopsy specimen of the colon revealed non-caseating granuloma. The association of ankylosing spondylitis and Crohn's disease has widely been known in Europe and United States; but this is the first case reported in detail in Japan, where incidences of both diseases were much lower than those found in Caucasians.

Adult↗
PubMed1989

[A case of systemic lupus erythematosus with urticarial vasculitis].

A 37-year-old woman with SLE who presented with urticarial vasculitis is reported. Skin biopsy revealed presence of polymorphonuclear and mononuclear leukocyte infiltration, nuclear dust, extravasation of red blood cells and fibrinoid necrosis of small vessels which are characteristic features of leukocytoclastic vasculitis. In the literature, 49 cases with similar skin lesion have been reported under various terminologies including unusual SLE related syndrome, hypocomplementemia with cutaneous vasculitis and arthritis, urticarial vasculitis or hypocomplementemic vasculitic urticarial syndrome. Approximately 50% of these cases fulfilled the revised criteria for SLE. It is suggested that these cases represent a unique group of patients with characteristic skin manifestations and polyarthritis mediated by immune complex, and closely relate to SLE.

Adult↗
PubMed1988

The AI/RHEUM knowledge-based computer consultant system in rheumatology. Performance in the diagnosis of 59 connective tissue disease patients from Japan.

AI/RHEUM is a knowledge-based computer consultant system for the diagnosis of rheumatic diseases. Its diagnostic accuracy was evaluated using information that was supplied by Japanese rheumatologists on 59 patients with connective tissue diseases. The diagnoses of the AI/RHEUM model were in full or partial agreement with those of the Japanese rheumatologists in 54 of 59 cases (92%). Preliminary evaluation of the criteria tissue disease showed a sensitivity of 90% and a specificity of 96%.

Artificial Intelligence↗
PubMed1988

Pyloric stenosis in a patient with progressive systemic sclerosis.

A 64-year-old Japanese woman with progressive systemic sclerosis (PSS) who developed severe pyloric stenosis is described. The conservative treatments brought only the temporary symptomatic relief, and pyloroplasty became necessary. No ulcerative lesions or tumors were found in the resected stomach or duodenum specimens implicated for stenosis. The histological examinations revealed edema and replacement fibrosis in the pyloric ring. The possible mechanisms of pyloric stenosis are discussed.

Female↗
PubMed1988

Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases.

Two patients with characteristic features of CREST syndrome and primary biliary cirrhosis are reported. Sera of both patients contained autoantibodies to centromere and mitochondrial antigens. Immunodiffusion analysis identified the specificities of precipitating antibodies to mitochondria of the first case as anti-M-A and M-C, and of the second case as anti-M-A and M-B antibodies. Simultaneous occurrence of 2 marker antibodies in an individual patient indicates that the 2 patients reported here have CREST syndrome and primary biliary cirrhosis, both of which are considered as a distinct clinical entity.

Aged↗
PubMed1987

Hypertrophic osteoarthropathy, cutaneous vasculitis, and mixed-type cryoglobulinemia in a patient with nasopharyngeal carcinoma.

We describe a 27-year-old woman with a primary nasopharyngeal carcinoma who developed hypertrophic osteoarthropathy and cutaneous vasculitis. Her serum contained antibodies to Epstein-Barr virus and U1 RNP antigens. Cryoproteins isolated from her serum contained antibodies to U1 RNP and a protein with a molecular weight of 32 kd which reacted specifically with antibodies to U1 RNP. HLA typing revealed HLA-B7 and DR1; these have been reported to be increased in Japanese patients with rheumatic diseases who have autoantibodies to U1 RNP. These findings indicate that some features of the paraneoplastic syndrome in this patient might have been caused by immune complexes, part of which were formed by specific autoantibodies produced under genetically controlled conditions of immune responsiveness.

Adult↗
PubMed1987

Autoantibodies to the Sm antigen: immunological approach to clinical aspects of systemic lupus erythematosus.

The precise antigenic peptide of Sm antigen (U small nuclear ribonucleoproteins, U snRNP) and the clinical significance of anti-Sm antibodies in systemic lupus erythematosus (SLE) detected by a sensitive radioimmunoassay were studied. By immunoblotting, anti-Sm sera reacted with B'/B peptides of U1 snRNP and D peptide of U1-U2 snRNP, while anti-U1 RNP recognized 68k, A, B'/B and C peptides. Reblotting study using the specific antibodies against each peptide eluted from the blot sheets demonstrated that B'/B and D peptides shared a common Sm antigenic epitope. We purified D peptide from U1 snRNP and established a radioimmunoassay. Anti-Sm antibodies were found in 30% of the patients with SLE using this method, which was more sensitive than the conventional assays. Anti-Sm was associated with late onset renal disease and poor prognosis when analyzed with Cox's regression model.

Autoantibodies↗
PubMed1986

In vitro production of autoantibodies to U1 ribonucleoproteins by peripheral blood mononuclear cells from patients with connective tissue diseases.

Antibodies to U1 ribonucleoproteins produced by peripheral blood mononuclear cells from patients with connective tissue diseases were measured by a sensitive enzyme-linked immunosorbent assay and by immunoblotting. Mononuclear cells from patients with high-titer serum antibodies spontaneously started secreting IgG anti-U1 RNP antibodies on the second day after culture. The amount of anti-U1 RNP in the culture supernatants reached maximum level on day 8. The most effective production of anti-U1 RNP by B cells was observed when they were cultured in the presence of T cells and adherent cells. Mononuclear cells from patients without anti-U1 RNP antibodies or from normal subjects did not produce a measurable amount of anti-U1 RNP. Treatment of mononuclear cells by cycloheximide resulted in complete inhibition of anti-U1 RNP secretion, which indicates that antibody in the culture supernatants reflects the active biologic phenomenon in vitro. The methods described should be useful in the study of the cellular mechanisms involved in antinuclear antibody production of connective tissue diseases.

Antigens↗
PubMed1986

Anti-Ro/SSA and -La/SSB antibodies in patients with connective tissue diseases.

The frequency of anti-Ro/SSA and anti-La/SSB antibodies in patients from Japan with Sjögren's syndrome, systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), polymyositis-dermatomyositis (PM-DM), rheumatoid arthritis (RA) and blood donors is reported. Anti-La/SSB ab was especially detected in patients with severe glandular and extraglandular manifestation and could be found in sera years prior to the confirmation of Sjögren's syndrome. The purified Ro/SSA antigen consisted of 60 k peptide and 16 k RNA while the La/SSB antigen consisted of 41 k and 29 k peptides. Some molecular association seems to exist between the peptides and corresponding IgG anti-Ro/SSA and anti-La/SSB antibodies.

Antibodies, Antinuclear↗
PubMed1983

The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases. A marker for a subset of polymyositis with interstitial pulmonary fibrosis.

The clinical significance of antibodies to the Jo-1 antigen in connective tissue diseases was studied. Clinical diagnoses of 11 patients who had anti-Jo-1 antibody were: polymyositis 8, dermatomyositis 1, and overlap syndrome 2 (polymyositis--systemic lupus erythematosus 1, polymyositis--scleroderma 1). All the patients who had anti-Jo-1 antibody showed interstitial pulmonary fibrosis, and in 2 patients anti-Jo-1 antibodies were detected before the appearance of lung disease.

Adult↗