PubMed Health⌕ Search

Biomedical subjects

M Ala-Opas

Publications and source records attributed to M Ala-Opas.

44 records · Page 3Linked to original sources
PubMed1989

Cystine urolithiasis in Finland.

Cystine stone material was collected from 27 patients treated in various hospitals in Finland. The prevalence of cystine stones was found to be one/year/1,000,000 inhabitants. A total of 49 operations were performed on 20 patients, with five nephrectomies carried out as the first stage of treatment in the patients with stones. Extracorporeal shock wave lithotripsy (ESWL) failed to fragment cystine stones in one patient and percutaneous stone removal was necessary. The delay in the diagnosis of cystinuria averaged 5.1 years. Most patients with cystine stones had homozygous cystinuria. Anuria due to recurrent stone formation occurred in three patients. Chronic urinary tract infection was seen in nine out of 15 (60%) women patients and four of these nine had inflammatory changes in the kidneys diagnosed by urography. Early diagnosis of cystinuria is important to avoid kidney injury and recurrence of cystine stones.

Adult↗
PubMed1987

Unprocessed bran and intermittent thiazide therapy in prevention of recurrent urinary calcium stones.

Both urinary calcium excretion and renal stone episodes are increased during the summer in Finland. Since thiazide and unprocessed bran are known to decrease urinary calcium excretion, we treated 73 patients with recurrent urinary stone formation by giving them unprocessed bran and intermittent thiazide. Of the patients, 32 had absorptive hypercalciuria and 41 had normal urinary calcium values. All patients were on a low-calcium and low-oxalate diet and took 40 g bran daily. Fourteen of the hypercalciuric and 14 of the normocalciuric patients were randomly allocated to use hydrochlorothiazide 50 mg b.i.d. from May to September. Reduction of stone formation was seen in all groups. The combination of thiazide + bran was superior to the bran on its own in inhibition of stone formation. Only 3/11 (27%) stones passed through during the summer in the thiazide + bran group as compared with the 11/17 (65%) in the bran group.

Adult↗
PubMed1985

Early results of the Finnish Multicentre Study of Prostatic Cancer (Finnprostate).

Four hundred and four prostatic cancer patients diagnosed in the years 1979-1982 in nine Finnish hospitals have been followed up for a mean period of three years. The aim of this study is to evaluate the situation of this malignancy in the Finnish male population and to discuss the diagnostic procedures and treatment modalities. In one fifth of the patients the carcinoma was as incidental finding on microscopical examination of tissue removed by transurethral resection or enucleation for presumed benign prostatic hyperplasia. At the diagnostic moment 69% of the tumours were locally advanced beyond the prostatic capsule and one third of all cases had metastasized. 134 out of 404 (33%) have died and 45% of these of prostatic cancer. Survival was adversely affected by the tumour differentiation grade. In non-metastasized cases the local extent of the tumour had no notable effect on prognosis. Some early comparisons are made between orchidectomy and oestrogen therapy.

Acid Phosphatase↗
PubMed1984

Five years of experience with selective therapy in recurrent calcium nephrolithiasis.

We evaluated the efficacy of selective treatment in 126 patients with recurrent calcium urolithiasis who were chosen on the basis of ability to correct underlying physiochemical disturbances. Patients with hyperparathyroidism underwent an operation. Patients with renal hypercalciuria were treated with thiazide and those with absorptive hypercalciuria were given a low calcium, low oxalate diet with or without thiazide. The only treatment for normocalciuric patients was high fluid intake, which was suggested also to the other groups. A significant individual mean reduction in stone formation was observed in all groups after 5 years of treatment. However, only 48 per cent of the normocalciuric patients were in remission after 5 years of high fluid intake therapy and 45 per cent of those with absorptive hypercalciuria were free of recurrence with diet only. Thiazide treatment seemed to be effective despite the type of hypercalciuria. The effect of the treatment on stone formation was mediated through reduction of risk factors in the urine. Conversely, a high level of risk factors commonly predicted stone recurrence.

Adult↗
PubMedDate not supplied

A primary carcinoid tumor of the kidney: a case report and review of the literature.

BACKGROUND: Primary carcinoids are found mostly in the gastrointestinal tract. Primary carcinoid tumor of the kidney is rare; only 28 patients have been reported. Because of the rarity of the lesion, its radiological and clinicopathological features are not well characterized. At the same time, its prognosis and histogenesis is unknown. METHODS: A 62-year-old patient presented with a carcinoid tumor on the isthmus of the horseshoe kidney. Radiological, clinicopathological, and immunohistochemical tests were performed. The tumor was resected. RESULTS: Two years later, metastasis were observed in the liver. The metastasis were treated with percutaneous ethanol sclerotherapy (PET). CONCLUSIONS: To our knowledge, this is the first case of primary renal carcinoid tumor present on the isthmus of the horseshoe kidney and the first case of carcinoid liver metastasis to be treated with PET.

Angiography↗
PubMedDate not supplied

A prognostic score for prostatic adenocarcinoma based on clinical, histological, biochemical and cytometric data from the primary tumour.

The aim of this study was to create a multivariate prognostic score for prostatic adenocarcinoma. A retrospective analysis of clinical, histological and cytometric prognostic factors in 325 cases of prostatic adenocarcinoma followed up on average over 13 years was performed. A multivariate prognostic score was built by using the independent prognostic factors. M-category, T-category, Gleason score and patient age were independent prognostic factors in the entire cohort. In MO tumors T-category, density of tumor infiltrating lymphocytes, the presence of apoptotic cells, and patient age were independent prognostic factors. In T1-2MO tumors the density of tumour infiltrating lymphocytes, mitotic index, standard deviation of maximum nuclear diameter and the serum level of acidic phosphatase were independent prognostic factors. By combining the coefficients of the regression model, a prognostic score was built for each of the tumour categories. The subsequent survival analysis based on the prognostic score indicated that it is a highly significant prognostic factor superior to individual prognostic parameters. The results show that the combination of prognostic data is a valuable tool in assessing the correct prognostic category for prostatic adenocarcinoma.

Adenocarcinoma↗