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Biomedical subjects

M Alcaraz

Publications and source records attributed to M Alcaraz.

15 recordsLinked to original sources

Laurin-Sandrow syndrome (mirror hands and feet and nasal defects): description of a new case.

A child with complete syndactyly of cup shaped hands and mirror polysyndactyly of the feet, together with a nasal defect, was identified out of a total of 1,031,439 livebirths. She had a pattern of multiple congenital anomalies which was similar to that first described by Laurin et al in 1964 and by Sandrow et al in 1970. Two more cases with a similar pattern of congenital anomalies have recently been published so this is the fifth reported case with this constellation.

Abnormalities, Multiple

Effects of radiation on rabbit thyroid gland ultrastructure.

The ultrastructure of irradiated rabbit thyroid gland (0 Gy, as control, 4 Gy, 8 Gy, 12 Gy, 16 Gy and 20 Gy X-ray) is studied. The thyroid gland of the control group shows ultrastructural features similar to those described in other mammals. Modifications in follicular ultrastructure and interfollicular connective tissue ultrastructure as well as the presence of small thyroid follicles, probably neoformed, are found to be dose-dependent. Follicular epithelium varies from simple cuboidal to simple squamous, the latter being characteristic of the highest X-ray dose. Follicular cells show numerous cytoplasmic light vesicles and a very extensive rough endoplasmic reticulum consisting of vacuolated cisternae. Sloughed cells are present at 8 Gy. A well-developed interstitial glandular tissue consisting of extensive extracellular matrix, abundant collagen fibres and dilated, irregularly outlined capillaries are also present.

Animals

Study of postmortem blood circulation.

The objective of this work was to study the postmortem redistribution of blood volumes and its influence of the distribution of substances of different molecular weight (194.2 and 150,000 Da). Lipiodol Ultrafluide, Omnitrast, or a radioisotopic mixture of aminohippuric acid and human IgG were injected into the left ventricle of a total of 20 rabbits divided into three groups. Our results demonstrate the importance of related factors, including left ventricular postmortem contraction, the arterial vascular bed, diffusion processes connected to the physicochemical characteristics of the substances, and the anatomical distribution of the vessels. Postmortem diffusion of aminohippuric acid to the urine was observed.

Angiography