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Biomedical subjects

M Aldridge

Publications and source records attributed to M Aldridge.

9 recordsLinked to original sources
PubMed2000

Arterial reconstruction for radial artery occlusion.

This study was designed to detail the history and symptoms of symptomatic radial artery vaso-occlusive disease and to evaluate the results of radial artery reconstruction. Thirteen patients with symptomatic vaso-occlusive disease of the radial artery unresponsive to management by nonoperative modalities were managed with arterial reconstruction. All cases were treated with reversed interpositional vein grafting from the radial artery in the forearm (end-to-side) to the deep arch distally (end-to-end). Patients completed preoperative and postoperative assessments of symptoms and function, cold sensitivity (cold intolerance), and digital microvascular perfusion (isolated cold stress test evaluation with laser Doppler fluxmetry). At the follow-up examination all vascular grafts were patent, as determined by Allen's testing and Doppler ultrasound. The patients reported symptoms and functional status that demonstrated significant improvement following reconstruction. Microvascular evaluations demonstrated a significant improvement in digital microvascular perfusion as assessed by laser Doppler fluxmetry and digital temperature recordings with a resultant resolution of ischemic pain, numbness, and ulceration.

Adolescent↗
PubMed1998

Arterial reconstruction in the ischemic hand and wrist: effects on microvascular physiology and health-related quality of life.

Patients were evaluated before and after arterial reconstruction surgery (1) to define the physiology of the digital microcirculation in chronic subcritical ischemia, (2) to demonstrate the short-term effects of successful arterial reconstruction on microvascular flow, and (3) to document the effects of surgery on symptoms, function, and health-related quality of life. Arterial insufficiency was the result of a proximal reconstructible occlusive lesion, 1 or more distal unreconstructible occlusions, and secondary reactive vasospasm. Microvascular physiology was evaluated by monitoring digital temperatures, microvascular perfusion (laser Doppler fluxmetry) and perfusion patterns (laser Doppler perfusion patterns (laser Doppler perfusion imaging). Following successful vascular reconstruction, digital temperatures and microvascular perfusion improved significantly, approaching control levels. Although cold sensitivity was unchanged, symptoms decreased and upper extremity function and health-related quality of life improved after successful proximal reconstruction in patients with 2-level arterial occlusion.

Adult↗
PubMed1997

Talking about feelings: young children's ability to express emotions.

OBJECTIVE: The aim is to establish which emotion-descriptive language is used by children at different ages. METHOD: Fifty-six children (aged 5 to 11 years) were presented with a set of plastic playpeople. Scenarios were enacted using the toys to elicit emotion descriptive vocabulary in response to the interviewer's question: How do you think s/he feels about that? Eight adult subjects participated as a control. RESULTS: Children under the age of 8 years have a limited repertoire of labels to describe emotions. Even 11-year-olds are unable to produce vocabulary which expresses emotion concepts described by adults. The implications of our findings for child-police interviews are discussed.

Adult↗
PubMed1994

Unlimited liability? Emotional labour in nursing and social work.

At the heart of the 'new nursing' is an emphasis on developing a close, holistic relationship between nurse and patient. Through this not only will healing be facilitated, and patients be encouraged to take responsibility for their own health, but the nurse will be placed firmly at the centre of the network of health professionals. Individual practitioners and the profession as a whole will achieve a clearer and more satisfying mission. This casting of the nurse as pivotal enabler parallels attempts to systematize social work theory and practice in the 1970s, and many common intellectual sources on relationship-building are used. But what are the supposed characteristics of the 'good relationship'? The paper argues that, while the new nursing endeavours to emphasize the social context of patients, health and illness, much of the psychotherapeutic literature called in support is essentialist: the social world is treated as a hindrance to the goal of 'authenticity'. Thus acquired professional knowledge and skills are devalued. Added to the potential of this for personal stress are risks for the profession itself. In circumstances of permanent financial pressure, foregrounding hard-to-measure criteria of success, like the quality of relationships, is very hazardous.

Clinical Competence↗
PubMed1985

Detection of reticulo-endothelial blockade with low-dose test agent.

Blood clearance and organ extraction of a low-dose reticulo-endothelial test agent, technetium labelled tin colloid (TTC), was measured in groups of rabbits pretreated with reticulo-endothelial blocking agents. Electron microscopy and ultrastructure analysis confirmed that Kupffer cells extracted TTC. Pretreatment with silica caused reduced Kupffer cell uptake and spillover of TTC into the spleen. Pretreatment with sheep red cells caused reduced Kupffer cell uptake and reduced splenic uptake but anti-fibronectin caused only reduced splenic uptake of TTC. TTC is a suitable agent to detect alteration of reticulo-endothelial function.

Animals↗
PubMed1980

The bifunctional enzyme formiminotransferase-cyclodeaminase is a tetramer of dimers.

Formiminotransferase-cyclodeaminase, an octameric protein of identical, bifunctional polypeptides of Mr = 62,000, yields a transferase-active fragment of Mr = 80,000 upon proteolysis with chymotrypsin in the presence of the inhibitor folic acid. The purified fragment contains one size of polypeptide, Mr = 39,000, on dodecyl sulfate gels. Cross-linking with the bifunctional reagent dithiobis(succinimidyl propionate) confirmed the dimeric structure of the purified fragment. Reaction of the native octamer with the very short bifunctional reagent difluorodinitrobenzene yields dimer and tetramer in excess of trimer, thereby indicating two types of subunit interaction in the protein. The isolation of a dimeric fragment after proteolysis and the results of cross-linking support a tetramer of dimers structure for the native enzyme. The purified transferase fragment has approximately 68% of the activity of the native enzyme, but has lost specificity for the naturally occurring polyglutamate derivatives of tetrahydrofolate. This is illustrated by an increase in Km for tetrahydropteroylpentaglutamate from 3.4 microM with the native transferase to 89 microM with the fragment transferase. It is suggested that the bifunctional enzyme may have only one polyglutamate binding site/pair of transferase-deaminase sites.

Ammonia-Lyases↗