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Biomedical subjects

M Alejo

Publications and source records attributed to M Alejo.

At least 19 recordsLinked to original sources
PubMed1996

Mesenchymal chondrosarcoma of the foot, an unusual location: case report and review of the literature.

We present a case of primary mesenchymal chondrosarcoma of the proximal phalanx of the first toe. The bones of the foot represent an infrequent primary site for this neoplasm. The tumour consisted of layers of undifferentiated round cells with scanty cytoplasm and hyperchromatic nuclei. The presence of brain, lung, and left auricle metastasis was demonstrated, and the patient died due to brain edema 18 days after admission. Mesenchymal chondrosarcoma is a rare tumor that more frequently involves the pelvic bones, the femur, and the humerus. To our knowledge, only nine cases of primary mesenchymal chondrosarcoma arising from the bones of the foot have been previously reported, with none involving the phalanx of the toe.

Adult↗
PubMed1996

Annular elastolytic giant cell granuloma--actinic granuloma?

A 56-year-old woman with annular elastolytic giant cell granuloma is reported. She had annular, slowly growing lesions on sun-exposed areas and the dorsum of one foot. Biopsies from both areas revealed a mid-dermal inflammatory infiltrate with many giant cells engulfing elastic fibres. The current nosological situation of this process is discussed. Actinic granuloma (AG) is a term coined by O'Brien in 1975 to describe a cutaneous process characterized by multiple annular lesions located on sun-exposed skin areas. The histopathology is defined by the presence of multinucleated giant cells containing elastic fibres at the lesion edge, and the absence of these fibres at the lesion centre. The nosology of this disease and the role of actinic exposure as a triggering factor for it has been much discussed in recent years. We report a new case of AG not limited to photo-exposed areas.

Female↗
PubMed1993

Detection of human papillomavirus 16 and 18 DNA in epithelial lesions of the lower genital tract by in situ hybridization and polymerase chain reaction: cervical scrapes are not substitutes for biopsies.

Human papillomavirus (HPV) types 16 and 18 in 66 women with histologically documented lesions of the genital tract and 64 control cohorts were investigated. The efficacies of in situ hybridization and polymerase chain reaction (PCR) in detecting HPV 16 and 18 DNA were analyzed. In order to assess the usefulness of replacing biopsies with cervical scrapes, the two samples were compared by PCR. The prevalence rates of HPV infection by PCR were 59.1 and 10.9% in patients and controls, respectively. PCR was three times more sensitive than in situ hybridization (52.6 versus 17.8%). However, the need to improve PCR sensitivity by subsequent dot blot hybridization reduced one of the main advantages of PCR, i.e., expeditious diagnosis. Cervical scrapes were less sensitive than biopsies (13.6 versus 53%), although with four (6.1%) patients with intraepithelial neoplasias, HPV DNA was identified only by means of cervical scraping. We conclude that obtaining biopsy specimens and cervical scraping are complementary sampling procedures.

Adolescent↗
PubMed1993

Adenocarcinoma in situ of the uterine cervix: clinicopathological study of nine cases with detection of human papillomavirus DNA by in situ hybridization and polymerase chain reaction.

The clinicopathological features of nine patients with adenocarcinoma in situ (AIS) of the uterine cervix, one of them with microinvasion, were studied. In situ hybridization (ISH) with biotinylated probes to human papillomavirus (HPV) types 6/11, 16/18, and 31/35/51 was performed in eight tumors. The presence of HPV types 16 and 18 was also investigated by the polymerase chain reaction (PCR) in seven. Four tumors were of the endocervical type, two were endometrioid, and three were mixed (endocervical-intestinal). Coexisting cervical intraepithelial squamous neoplasia (CIN) was found in eight tumors. Only one of the eight tumors studied by ISH was positive for HPV 16/18 in the dysplastic squamous epithelium, but none of them showed positivity in the adenocarcinomatous areas. In contrast, four of seven AIS studied by PCR were positive: three for HPV 16 and one (the microinvasive adenocarcinoma) for HPV 18. The results confirm the frequent association of AIS with CIN and HPV.

Adenocarcinoma↗
PubMed1991

[Gastric carcinoma with a lymphoid stroma].

Carcinomas with lymphoid stroma have been described in different locations: breast, uterine cervix, nasopharynx, esophagus and stomach. These neoplasms have a better prognosis probably due to the lymphoid reaction that takes place in the tumoral stroma. For this reason many authors prefer to consider this entity separate from the rest of gastric carcinomas. We present a case of gastric carcinoma with lymphoid stroma and neuroendocrine features. Such association has not been previously described in the Spanish literature.

Adenocarcinoma, Mucinous↗
PubMed1991

[Adenolymphoma or Warthin's tumor: review of 30 cases].

Perusal of Warthin's tumors treated during the past 20 years (1969-1989) in our Hospital department. As a whole 229 tumors of salivary glands were operated upon, 30 of them being adenolymphomata. The parameters of our series were confronted with those given by the cases of the literature. In the paper are also reminded the several theories concerning the origin of this tumor.

Adenolymphoma↗
PubMed1990

Cavernous angiomas of the cranial nerves. Report of two cases.

Two cavernous hemangiomas arising in the third and eighth cranial nerves, respectively, and presenting as space-occupying lesions are reported. The tumors posed problems in the preoperative differential diagnosis. The main clinicopathological features of these tumors are discussed.

Adult↗
PubMed1989

[Malignant nongranulomatous pulmonary hypertension in a patient addicted to parenteral drugs].

We report the first case in the Spanish literature of pulmonary hypertension (PHT) caused by vascular sclerosis in a parenteral drug abuser female. The clinical diagnosis of PHT was confirmed in the necropsy study, which ruled out granulomas and discovered only vascular sclerosis and hypertrophy as causative factors of the clinical picture. The different etiological and pathogenetical mechanisms reported in the literature as causing PHT in this type of patients are reviewed.

Adult↗
PubMedDate not supplied

[A retropharyngeal synovial sarcoma].

The synovial sarcomas constitute the 7-10% of the soft tissue malign tumors, with a preferred location in the limbs. In the head and neck a 5% of the totality are placed. We present one case of retropharyngeal synovial sarcoma and the accomplished treatment, together with a revision of the bibliography.

Adolescent↗
PubMedDate not supplied

[Adenocarcinoma of the nose and paranasal sinuses. Presentation of 3 cases].

Three cases of intestinal type adenocarcinomas of the nose and sinuses are described. In two of them the tumors were associated with an extended exposure to wood dust, while no association with any known exposure factor was detected in the third. Clinical history, pathology, treatment and follow-up of each case are reviewed.

Adenocarcinoma↗
PubMedDate not supplied

[Pleomorphic adenoma of the nasal cavity. Presentation of a case].

We display a case of a female patient with a pleomorphic adenoma localized in the nasal fossa, with 10 years of evolution and that has been extirpated by an external way. We review the bibliography, we emphasize the rareness of the locality and make considerations about clinic, prognostication and treatment.

Adenoma↗