PubMed Health⌕ Search

Biomedical subjects

M Altissimi

Publications and source records attributed to M Altissimi.

15 recordsLinked to original sources
PubMed2006

Treatment of post-traumatic hand Staphylococcus aureus osteomyelitis with oral linezolid.

The Authors report on the use of linezolid for the treatment of three patients with osteomyelitis. All three patients had post-traumatic multisensitive hand bone methicillin-susceptible Staphylococcus aureus osteomyelitis, which did not respond to antimicrobial regimens including drugs in vitro active against the isolated strains. Clinical cure and microbiologic eradication was obtained with oral linezolid in all three patients. Linezolid was well tolerated. Mild thrombocytopenia was observed in one patient at the end of the third week of treatment and it was promptly resolved after the discontinuation of linezolid. Linezolid minimum inhibitory concentrations (MICs) consisted of 2 mg/l for all three S. aureus isolates while the bactericidal activity in vitro was not present up to the linezolid concentration of 32 mg/l. In spite of a lack of in vitro bactericidal activity, linezolid was effective in curing the patients and eradicating the infection. Trough and peak plasma concentrations of linezolid were above the MICs of the isolates. These values ranged from 3.93 to 14.95 mg/l at trough and 5.03 to 25.91 mg/l at peak. The oral bioavailability, pharmacokinetic profile and antibacterial spectrum of linezolid make this oxazolidonone antimicrobial an attractive drug for the treatment of chronic osteomyelitis. Prolonged administration requires careful surveillance for side effects, until these complications are better understood.

Acetamides↗
PubMed1994

Early and late displacement of fractures of the distal radius. The prediction of instability.

One hundred fractures of the distal radius with dorsal displacement were treated by closed reduction and a plaster cast. The mean age of the patients was 55 years. Radiographs were taken after 1, 2 and 5 weeks to evaluate the frequency of early and late displacement. Dorsal angulation occurred in 71 patients, shortening of the radius in 47 and flattening of the radial angle in 32. Late displacement was more frequent than early. Statistical analysis showed a greater incidence of secondary shortening in Older's types III and IV fractures. The severity of the initial radial shortening was the most reliable indication of instability.

Chi-Square Distribution↗
PubMed1991

Results of primary repair of digital nerves.

Recovery of sensitivity following repair of 54 digital nerves was evaluated after one to seven years. Normal two-point discrimination has been regained in only seven cases (13%), two-point discrimination between 6 and 10 mm in 20 (37%), between 11 and 15 mm in 13 (24%) and protective sensation in 14 (26%). A close correlation between age and recovery of sensation after repair has been confirmed by statistical analysis. Microsurgical repair of digital nerves gives satisfactory results, since a normal or good two-point discrimination can be obtained in one-half of cases while sensation improves in the others. However a high rate of complete recovery of sensation is to be expected only in children.

Adolescent↗
PubMed1991

Comminuted articular fractures of the distal radius. Results of conservative treatment.

Fifty-nine comminuted articular fractures of the distal radius which had received conservative treatment were reviewed after an average of 3 1/2 years. The results--excellent in 15 patients, good in 30, fair in 12, and poor in 2--were closely linked to the quality of the articular reduction. In patients with a residual malalignment greater than 2 mm, a relatively high incidence of both degenerative arthritis (31%) and unsatisfactory results (56%) was found. The presence of a "die punch" fragment often precluded acceptable fracture reduction and was therefore responsible for many poor clinical and radiographic results. The quality of the extraarticular reduction proved to be of little importance to the final outcome.

Adult↗
PubMed1988

Surgical release of the median nerve under local anaesthesia for carpal tunnel syndrome.

Carpal tunnel release was performed under local anaesthesia in 124 wrists of 108 patients. The local anesthetic was injected into the carpal tunnel and into the subcutaneous tissue under the line of the skin incision. A tourniquet was used in all cases. Analgesia was complete in all but six patients. Only one patient had real difficulty in tolerating the tourniquet. In 18 cases the median nerve, when exposed at operation, showed evidence of some damage caused by the needle or by injection of local anaesthetic but, at follow-up, no symptoms or signs related to this damage were found.

Adult↗
PubMed1987

Perilunate dislocations of the carpus. A long-term review.

The long-term results of 19 perilunate dislocations of the carpus (including 9 transscapho-perilunate dislocations) were: good, 7 cases; fair, 8; poor, 4. The 9 transscapho-perilunate dislocations gave worse results than simple dislocations, with pseudarthrosis in 5 cases. Arthrosis was found in more than half the cases, more frequently in transscapho-perilunate dislocations and in cases associated with a fracture of the radial styloid. Radiographic signs of instability were observed in 8 wrists. The unstable wrists had a high incidence of arthrosis and showed decidedly worse clinical results compared to stable wrists (good, 1; fair, 4; poor, 3, as compared to good, 6 and fair 4). In all the unstable wrists we therefore believe that the results may be improved if the radiographic signs of instability are specifically looked for immediately after reduction so that abnormal anatomical relationships in the carpus can be corrected early.

Adolescent↗
PubMed1986

Ulnar nerve compression at the elbow level.

The long-term results are reported (average 9 years) of anterior transposition of the ulnar nerve into a muscular groove in the treatment of ulnar nerve compression at the elbow level. The series of 27 elbows consisted mostly of patients with muscle deficit. The results were examined in relation to the preoperative duration of symptoms, particularly weakness and wasting of muscles, and were satisfactory in 78% of cases in that recovery of the muscle deficit was either complete or showed marked improvement. When the duration of symptoms exceeded one year, the results were less satisfactory.

Elbow↗
PubMed1986

Long-term results of conservative treatment of fractures of the distal radius.

The long-term results of the conservative treatment of wrist fractures were observed in a follow-up study of 297 cases over a period of one and one-half years to six years. The evaluation of the results was based on clinical parameters, both subjective and objective, as well as radiological features. The results were: excellent in 38% of cases, good in 49%, fair in 11.5%, and poor in 1.5%; considerably worse were the subjective results (20% fair to poor). No statistically significant relation could be found between results and type of fracture. Clinical deformities and pain in the area of the distal radioulnar joint were frequent. Decrease in grip strength was observed in 17.8% of cases. A limitation of wrist movement was not frequent. Numerous compressive neuropathies were found (41 in 35 patients), especially of the median nerve. The values relative to the three radiographic parameters under investigation (that is, radial deviation, volar tilt, and radioulnar index) were often found to be out of the normal range. The comparative study of postreduction and follow-up radiograms show the loss of reduction to be frequent, especially as far as the volar tilt is concerned. The frequent radiologic deformities are associated with significantly bad results only in cases of extremely abnormal values. However, fractures of the distal radius are not to be underestimated. Long-term results following conservative treatment may not be as acceptable as is generally assumed.

Adolescent↗
PubMed1981

Osteosynthesis of closed femoral shaft fractures by plate fixation: indications and results.

Osteosynthesis of fractures of the shaft of the femur by plating is not so widely used as intramedullary nailing. It does, however, have precise indications in certain situations that preclude the use of nails or render them inadvisable. The purpose of the present paper is to make a contribution to this aspect of the problem, the literature on which is by no means extensive. The results of forty-seven cases, performed on the basis of the writers' indications, are reported after a long term follow up period.

Adolescent↗
PubMed1980

Results of rigid fixation in 54 supracondylar fractures of the femur.

We present the results of the internal fixation in 48 supracondylar fractures of the femur with a follow-up of 1 to 10 years. These fractures have been classified according to the criteria proposed by the AO international. The clinical results were excellent to good in 70.9% of the cases, fair to bad in 22.9%, and failures (due to pseudarthrosis and osteomyelitis) in 6.2%. Significantly inferior results were obtained in articular, open, and imperfectly reduced fractures. The frequent comminution of these fractures often interfered with anatomic reduction, which explains the elevated number of consolidations in varus and/or recurvation.

Adolescent↗
PubMedDate not supplied

Surgical treatment of the rheumatoid hand.

Multiple involvement of joints and tendons of the hand by rheumatoid disease is frequent and may result in severe deformities. Surgery plays a major role in an integrated treatment program that considers the patient's possibilities for improvement. Extensor and flexor tenosynovitis requires an early synovectomy to prevent tendon ruptures, to restore tendon gliding and to decompress the median nerve at the wrist level. Ruptured tendons are usually widely degenerated and restoration of function is provided by end-to-side repair, tendon grafts or tendon transfers. Joint synovectomies must be preformed at an early stage to be effective. Restoration of function in eroded, dislocated or unstable joints can be attained by arthroplasty or arthrodesis. A resection arthroplasty, usually completed by a silicone implant, corrects the deformity while preserving or restoring a functional range of motion. Flexible implant arthroplasty is very often performed in the metacarpophalangeal joints, and less frequently in the wrist and interphalangeal joints. Arthrodesis is a satisfactory procedure for those joints where stability is more important than motion.

Arthritis, Rheumatoid↗