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Biomedical subjects

M Ambrosini

Publications and source records attributed to M Ambrosini.

25 records · Page 2Linked to original sources
PubMed1980

Cardiotoxicity from orphenadrine intoxication in humans.

Eight cases of Orphenadrine intoxication were treated in the Resuscitation Centre of Rome's University Medical School. All these cases arrived in coma, after taking an overdose of Orphenadrine in an attempt at suicide. The clinical signs and therapy are reported in detail; the cardiovascular side-effects, in particular those involving arrhythmias are dangerous and life threatening. From the clinical data it is believed that these changes in rhythm are mostly due to the autonomic nervous system (A.N.S.). In fact all the 8 patients survived, without treatment never having been treated with cardiokinetic or antiarrhythmic drugs, but a few were given Diazepam as well as respiratory assistance, cardiovascular assistance, and forced diuresis.

Adolescent↗
PubMed1979

[Nocturnal asystolia revealed with Holter monitoring in asymptomatic hypokinetic arrhythmia. Report of two cases (author's transl)].

The Authors report on two cases of hypokinetic arrhythmia with good ventricular rate during the day. In these cases the Holter monitoring showed, during the night, a marked slow down of the cardiac rhythm with short period of cardiac arrest up to 4280 ms. The Authors would like to underline the prognostic and therapeutic importance of the above said remarks, also mentioned by others in the most recent literature, and the necessity to go deeply in to the meaning of these events specially about possibility of sudden death and cerebral hypossia, during the slow down of cardiac rhythm. In both cases a good therapeutic effect, consisting in a complete normalization of the cardiac rate, has been optained with sustained preparation of sympaticomimetic and vagolitic drugs. On the basis of their experience, the Authors think that, in these cases, the pharmacologic therapy, neglected during the last years, could give a good therapeutical result.

Adult↗
PubMedDate not supplied

Heart rate stationarity in heart transplanted patients.

The heart rate stationary was studied by tachographic of 24 Holter analysis in 15 normal subjects and in 13 recipient subjects that were heart transplanted at least 5 years and that, at the time of our research, presented a very good post-operative course. To test the stationary heart rate we performed a scanning of Holter in qualified strips of four beats in which the three consecutive intervals demonstrate a constant acceleration or deceleration sequential variations of tachographic values. The results obtained demonstrated that in normal and transplanted subjects stationary and non stationary strips are evident. Both in normal and in transplanted subjects non-stationary strips are prevalent, although in different ways: in normal subjects the stationary and non-stationary ratio is 1:1.40; in transplanted subjects the ratio is 1:1.68. Non-stationary strips, that in the cartesian plane do not demonstrate any directional variation, in normal subjects are, on average, higher than in transplanted subjects. The same phenomenon is available for the strips with only one variation. The strips with three consecutive variations are much more evident (more 50%) in transplanted subjects. These strips are also more numerous compared to the sum of all the other strips with a single variation. The statistical analysis demonstrates that the difference between the normal and the transplanted subjects is significative. Our data can suggest an absent autonomic nervous system regulation and can confirm the results we obtained in these patients using a phase space analysis of the same Holter recording.

Adult↗