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Biomedical subjects

M Amini

Publications and source records attributed to M Amini.

At least 37 records · Page 2Linked to original sources
PubMed1996

Surgical resection of pulmonary metastases from colorectal carcinoma. Five-year survival and main prognostic factors.

Between 1986 and 1994, 19 patients underwent pulmonary resection for metastatic colorectal carcinoma. The mean interval between colon resection and appearance of pulmonary metastasis was 41 +/- 21 months. All the patients had no more than two metastases. Wedge resection alone or associated with lobectomy was performed in four patients, lobectomy in ten, and pneumonectomy in five. One patient died within the month after surgery. Mean follow-up was 35 +/- 26 months. The 5-year survival rate was 38.7%. Repeat thoracotomy for recurrent metastases was performed in one patient. The disease-free interval, the size of metastases, the type of pulmonary resection, and the location and the stage of primary cancer had no apparent influence on survival, but the survival rate at 4 years was 25% for patients with high carcinoembryonic antigen (CEA) level versus 80% for those with low CEA level. We conclude that, at least when the number of metastases is less than two, resection of colorectal lung metastasis is safe and effective.

Aged↗
PubMed1996

Interobserver variability on the histopathologic diagnosis of cutaneous melanoma and other pigmented skin lesions.

PURPOSE: To assess the interobserver agreement on the diagnosis and classification of cutaneous melanoma. MATERIALS AND METHODS: A set of 140 slides of cutaneous melanoma, including a small subset of benign pigmented skin lesions, were circulated to four experienced histopathologists. The kappa statistic for multiple ratings per subject was calculated using the method described by Fleiss. RESULTS: The kappa value on the diagnosis of cutaneous melanoma versus benign lesions was 0.61. There was some discordance on the diagnosis in 37 of 140 cases (26%). For the histopathologic classification of cutaneous melanoma, the highest kappa values were attained for Breslow thickness (kappa = 0.76) and presence of ulceration (kappa = 0.87). The agreement was generally poor for other histologic features, such as level of dermal invasion (kappa = 0.38), presence of regression (kappa = 0.27), and lymphocytic infiltration (kappa = 0.27). CONCLUSION: Our study suggests considerable disagreement among pathologists on the diagnosis of melanoma versus other pigmented lesions. Tumor thickness and presence of ulceration are the most reproducible histologic features of cutaneous melanoma.

Humans↗
PubMed1993

Time course of changes in free thyroid indices, rT3, TSH, cortisol and ACTH following exposure to sulfur mustard.

In order to evaluate the time course of changes in serum concentration of thyroid hormones, cortisol and ACTH in patients exposed to chemical weapons containing sulfur mustard, we measured serum concentrations of hormones on the first, third and fifth week following injury in 13 soldiers and compared them to the results obtained from 34 control men. Free T4 and T3 indices were decreased and rT3, cortisol and ACTH were increased in the first week following exposure. There was a subnormal TSH response to TRH in 2 of 3 men tested. Except for an increase in FT4I and a decrease in TSH by the third week, and a steady decline in serum cortisol, serum hormone concentrations were unchanged until the fifth week after injury. The decline in serum cortisol occurred despite a constant increase in serum ACTH. By the fifth week only 1 of 13 men had serum cortisol levels > 10 micrograms/dl. We conclude that exposure to chemical weapons containing sulfur mustard results in alterations in serum concentrations of thyroid and adrenal hormones and ACTH, resembling changes seen in burn trauma. Some evidence of direct effects of mustard on endocrine glands exist.

Adrenocorticotropic Hormone↗
PubMed1988

Primary Kaposi's sarcoma of the lymph node in children.

A case of primary Kaposi's sarcoma of the lymph node (single node involvement) is reported on here. It occurred in a white, Italian boy 10 years of age. An extensive review of the literature showed that this was only the second childhood case of the disease among non-acquired immune deficiency syndrome (AIDS)-related people of the Western world.

Child↗
PubMed1987

[Echographic diagnosis of diffused liver diseases: histologic correlations].

A personal series of 53 patients is reviewed. The patients were subjected to echography of the liver together with clinical and histological studies after closed biopsy. The cases are analysed and grouped according to stage and severity of the liver condition encountered. All groups showed a good match between echographic and clinicohistological results. The main echographic criteria for liver disease are summarised and illustrated in the light of personal experience and the data published in the most recent literature.

Biopsy↗
PubMed1980

Histiocytoid cardiomyopathy in infancy: a new hypothesis?

A case of histiocytoid cardiomyopathy in a ten-month-old boy is reported. Histologic and ultrastructural examinations led us to consider the possibility that the disease, rather than being a focal lesion of the common myocardium as it was heretofore considered, might be regarded as a diffuse lesion on the specific myocardium.

Cardiomyopathies↗
PubMedDate not supplied

Littoral cell angioma of the spleen: an additional report of four cases with emphasis on the association with visceral organ cancers.

AIMS AND BACKGROUND: Littoral cell angioma (LCA) is an uncommon vascular tumor of the spleen recently described and interpreted as the tumoral counterpart of the normally present littoral cells lining the splenic sinus channels of red pulp. The diagnosis of LCA is suggested by a quite characteristic morphology and confirmed by the demonstration of a hybrid endothelial/histiocytic phenotype. METHODS: Four original and previously unreported cases of LCA are presented. All four splenic vascular tumors were investigated by light microscopy and immunohistochemistry for endothelial and histiocytic markers. RESULTS: All four cases were associated with visceral epithelial malignancies (colorectal adenocarcinoma in two cases, renal and pancreatic adenocarcinoma in one case each). One case was also associated with an intracranial tentorial meningioma. CONCLUSIONS: We consider our findings as a novelty and signal the possible existence of a clinical syndrome. Five of a total of 21 previously reported cases in the literature were also described as being associated with other cancers (non-Hodgkin's lymphoma in two cases, two not further specified tumors of the liver and brain, an epithelial ovarian cancer, and a non-small cell lung cancer in one case each). Close follow-up and careful investigation in search of a second visceral neoplasm are strongly recommended in cases of LCA, but further clinical observations and more in-depth genetic and molecular studies are needed before any valid conclusions can be drawn.

Aged↗
PubMedDate not supplied

Effects of iodized salt consumption on goiter prevalence in Isfahan: the possible role of goitrogens.

OBJECTIVE: To evaluate the success of the Iranian Iodine Deficiency Disorders Committee in achieving World Health Organization (WHO) goals for reducing the prevalence of goiter in children by adding iodine to table salt beginning in 1989. METHODS: In 1997, 8,000 male and female 6- to 18-year-old students were selected by cluster sampling in schools of Isfahan. Their thyroids were examined by four endocrinologists, and goiter was staged on the basis of the WHO classification. As an index of iodine consumption, urinary iodine concentrations were measured in 3,000 students. RESULTS: Goiter was observed in 62% of the students. Of the overall study group, 94% had sufficient iodine consumption (urinary iodine concentration of 10.0 microg/dL or more). Of those students who had sufficient iodine intake, 63.2% had goiter. Of the 6% of students with iodine deficiency, 5% had mild, 0.9% had moderate, and only 0.1% had severe iodine deficiency. Goiter was absent in half of the students with severe iodine deficiency. The prevalence of goiter in 6- to 10-year-old children was 65%. CONCLUSION: Despite sufficient iodine intake, the prevalence of goiter is still high in Isfahan City. Apparently, either this high prevalence has no relationship to iodine deficiency and possibly other unknown goitrogens are involved in the pathogenesis of goiter in Isfahan or the period of iodine intake has been too brief to affect thyroid sizes. Inasmuch as goiter prevalence is also high in the 6- to 10-year-old children, who have had iodized salt available for most of their lives, the second option is less probable. Another possibility is an increased rate of autoimmune thyroid diseases (because of iodine repletion) that resemble goiter during their early stages.

Adolescent↗
PubMedDate not supplied

An ion-pair high-performance liquid chromatography method for stability studies of epinephrine acid tartrate in injectable solution.

An isocratic technique was developed for the analysis of epinephrine acid tartrate using ion-pair high-performance liquid chromatography (HPLC) with UV detection and a phenyl reversed phase column. The chromatographic separation was accomplished by a mixture mobile phase consisting of methanol: water (50:50, v/v) containing 7.28 mM sodium dodecyl sulfate adjusted to pH 3.5. The stability of the drug in injectable solution was studied. Using the kinetic information generated from the high temperature studies at 70, 80 and 90 degrees C, an Arrhenius plot for epinephrine acid tartrate degradation was constructed and the shelf life of the drug was estimated. We concluded that the shelf life of epinephrine acid tartrate at room temperature (25 degrees C) was 346.1 days.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

Synthesis and calcium channel antagonist activity of nifedipine analogues containing 4(5)-chloro-2-methyl-5(4)-imidazolyl substituent.

Dihydropyridine having substituted imidazole at 4-position in conjunction with various C3, C5 diesters have calcium channel antagonist activity. In this paper a group of dialkyl, dicycloalkyl and diaryl ester analogues of nifedipine, in which the ortho-nitro phenyl group at position 4 replaced by 2-methyl-4(5)-chloro-5(4)-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists using the high K+ contraction of guinea-pig ileal longitudinal smooth muscle (GPILSM). The results for the symmetrical ester series showed that increasing the length chain in C3 and C5 ester substituents increased activity. When increasing of the length or lipophilicity accompany with increasing the hindrance, the activity decreased. In asymmetrical diester series, the results showed when R1 is methyl or ethyl, increasing of the lipophilic property in R substituent increases the activity if this high lipophilicity don't accompany with steric hindrance. Our results demonstrate that in symmetrical and asymmetrical series aromatic compounds were more active than aliphatic compounds. In symmetrical diesters compounds, the most active compound was diphenylethyl ester derivative, that it was more active than the reference drug nifedipine. These structure activity data indicate that the 2-methyl-4(5)chloro-5(4)-imidazolyl moiety is bioisoester of 2-nitrophenyl and 2-chlorophenyl moieties.

Animals↗
PubMedDate not supplied

[Extemporaneous examination of the sentinel lymph node in breast cancer: is the glass half full or half empty?].

Intra-operative examination of sentinel LN is controversial. Concordance with definitive exam of SLN in this series was 81%, though only 54% of positive cases were diagnosed. Micrometastases and ITC were usually lost intraoperatively, accounting for 14% of cases. Frozen section and touch prep of the SLN were approximately equivalent. The latter has the advantage of preserving tissue for step-analysis of SLN. The ultimate method of intraoperative analysis of SLN which can combine cost-effectiveness and accuracy needs to be determined.

Aged↗