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M Andersen

Publications and source records attributed to M Andersen.

204 records · Page 12Linked to original sources
PubMedDate not supplied

Drug-specific characteristics of thrombocytopenia caused by non-cytotoxic drugs.

OBJECTIVE: To analyse drug-specific clinical characteristics and to investigate the possible influence of epidemiological and other factors on thrombocytopenia induced by selected non-cytotoxic drugs. METHODS: A retrospective analysis of drug-induced thrombocytopenia reported to the Danish Committee on Adverse Drug Reactions. One-hundred and ninety-two cases induced by the most frequently reported drugs were included and analysed from data extracted from report forms and discharge summaries. RESULTS: Pronounced drug-specific differences in the clinical appearance of thrombocytopenia were registered. Severe thrombocytopenia with haemorrhagic manifestations was reported following exposure to gold salts, non-steroid anti-inflammatory drugs, sulfonamide antibiotics, cinchona alkaloids and vaccines. Valproic acid-induced thrombocytopenia was dose-dependent. The differences were primarily determined by the drug itself and also by its usage pattern. No specific patient-related factor responsible for the heterogeneity of the clinical appearance of the adverse reaction was identified. Factors related to the physician, such as monitoring recommendations or level of attention towards the adverse reaction, seemed to be of little significance. CONCLUSION: The primary determinant of the clinical characteristics of thrombocytopenia induced by noncytotoxic drugs is the offending drug.

Adolescent↗
PubMedDate not supplied

A psychosocial screening tool for ambulatory health care clients: a pilot study of validity.

This study tested the concurrent validity of a psychosocial screening tool, the Assessment of Life Conditions Scale (ALC), a brief checklist developed at Kaiser Permanente Health Maintenance Organization. It was found to be a significant predictor of a client's score on two longer valid and reliable psychosocial screening tools, the Social Readjustment Rating Scale and the Heimler Scale of Social Functioning. Clients' ALC scores were significantly correlated with their perception of their current and usual health status. Their ALC score was also associated with their perception of how they felt a nurse could be most helpful to them during their clinic visit. This brief screening tool has potential usefulness for guiding mental health referrals for ambulatory health care clients and for planning nursing care.

Ambulatory Care↗