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Biomedical subjects

M Andre

Publications and source records attributed to M Andre.

At least 37 records · Page 2Linked to original sources

Perspective: three-dimensional imaging of the musculoskeletal system.

An evaluation of musculoskeletal disorders in 202 patients using three-dimensional CT displays has revealed the usefulness of the technique, especially in patients with fractures of skeletal areas with complex anatomy, articular disorders of the hip, and spinal stenosis. In some cases, plastic models of diseased areas have been created from the CT data and are reasonably accurate, providing a graphic representation of the disease and the ability to perform rehearsal surgery. A preliminary investigation of three-dimensional displays of MR images indicates that the technique is feasible, although its clinical practicality requires further analysis.

Fractures, Bone

Estimation of virus density in sewage effluents by two counting techniques: comparison of precisions as a function of inoculum volume.

Two titration methods for the quantification of viruses present in the environment are compared--plaque counting and determination of the most probable number with a large number of inocula at each dilution. Titration of virus suspensions and of sewage samples showed that, for a given volume of inoculum, in most cases there was no statistically significant difference between the virus titres given by the two methods. The precision of the results was the same for the two methods. When the volume of inoculum used at each dilution differed from one method to another, the width of the confidence interval increased as the volume of inoculum decreased.

Bacteriological Techniques

Influence of Mn(II) on NMR relaxation times of biological fluids.

The extent that various concentrations of the paramagnetic metal ion manganese [Mn(II)] affect nuclear magnetic resonance (NMR) relaxation times was studied in vitro. Serial dilutions of Mn(II) were prepared in distilled water, 4% human serum albumin, dog plasma, dog gallbladder bile, and dog hepatic bile. T1 and T2 of each were measured at 10.7 M Hz using magnetization recovery and spin-echo radiofrequency sequences, respectively. The results show that relaxation rates (1/T1 and 1/T2) increase in a linear manner with increasing concentration of Mn(II) in all of the solutions tested. Mn(II) dissolved in dog gallbladder and hepatic bile, dog plasma, and 4% human serum albumin reduced relaxation times to a greater extent than Mn(II) in water. T1 times were reduced to a greater extent than T2 values. Thus, in T1 weighted magnetic resonance images, the NMR signal used to produce images would be more sensitive to the presence of Mn(II) in these biological fluids than in water. Furthermore, the magnitude of this in vivo effect of Mn(II) on NMR relaxation parameters depends not only on the concentration of this paramagnetic ion, but also on the constituents comprising the biological fluids (intra- and extracellular water, bile, plasma) and the nature of the chemical molecular interactions between these constituents and Mn(II).

Animals

[Evaluation of the viral contamination of the sea water after the emission of an effluent into the sea (author's transl)].

Research of virus in the sea water has been made by the concentrated method of adsorption-elution on glass powder. --This method has enabled us to strike the balance on the concentration of virus in the sea water, from the emission to the bank. The frequency of isolation of virus in the bathing zone considered as healthy is very high. The concentration of virus is practically constant in the length of an axis, 200 m distant in comparison with the bank.--The increase of particles of virus in the sea, in the estuary of the emission, reflects in the same way in the bathing zone, 5 m away from the bank. The phenomenon of dilution of the effluent in the sea water doesn't seem to play a part.

Bathing Beaches

[Distribution of Streptococcus pneumoniae serotypes in Nantes Hospital (1969-1978) (author's transl)].

Between 1969 and 1978 at the CHR of Nantes we isolated Streptococcus pneumoniae from 815 swabs taken from 591 patients and which provided 595 different strains. Serotyping of all the strains was carried out using the capsular reaction test. The prevalence of the different serovars varied according to the year and the type of swab. No resistant strains to benzylpenicillin or ampicillin were observed. There was significant resistance to sulphonamides and tetracycline : 24,3 and 29,6% respectively. The American vaccine containing the greatest number of serovars was effective for only 69,8% of the strains isolated in Nantes.

Anti-Bacterial Agents

Transcutaneous PO2 monitoring (tcPO2) in the newborn during apneic spells, convulsions, cardiac catheterizations, and exchange transfusions.

Continuous transcutaneous PO2 recording improves the monitoring of critically ill infants and newborns submitted to invasive procedures such as exchange transfusions or cardiac catheterization. The measurement of tcPO2 in babies with apneic spells or seizures gives a better understanding of these respiratory disorders. It is reasonable to recommend the continuous monitoring of PO2 with a transcutaneous electrode in neonatal intensive care units.

Apnea

[Hydranencephaly. Major cerebral lesions with normal neonatal neurologic behavior].

Case report of an 8 days old girl who had a discrete increase in head circumference associated with moderate EEG abnormalities. Familial and obstetrical histories were negative. Skull transillumination, contrast ventriculography and carotid arteriography led to the diagnosis of hydranencephaly. The cerebral lobes whose blood supply is dependent from the internal carotids were missing and were replaced by cavities. The normal neonatal neurological behaviour which did not change till death at 3 months, is a stiking phenomenon.

Anencephaly