Biomedical subjects

M Andriola

Publications and source records attributed to M Andriola.

11 recordsLinked to original sources

PubMed1993

Parainfectious optic neuritis and encephalomyelitis. A report of two cases with thalamic involvement.

Two children developed mental status alteration and bilateral profound visual loss secondary to optic neuritis. The clinical picture was consistent with parainfectious encephalomyelitis. Magnetic resonance imaging showed bilateral involvement of the thalamus in both cases. In one case the thalamic involvement was solitary and was suspected initially to represent a primary thalamic neoplasm. This was ruled out by a stereotactic biopsy of the thalamus, which showed perivascular inflammation consistent with parainfectious encephalomyelitis. The clinical and neuroimaging findings improved significantly following corticosteroid administration. Several relapses occurred upon initial attempts at corticosteroid cessation.

Child, Preschool↗

PubMed1982

Encephalopathy and fatal myopathy in two siblings. Their association with partial deficiency of muscle carnitine.

Two brothers had intermittent episodes of muscle weakness, lethargy, hyperammonemia, rhabdomyolysis, and elevated activities of creatine phosphokinase (CPK), lactic dehydrogenase, and SGOT in serum associated with low muscle carnitine but normal serum carnitine concentrations. These siblings represent a "mixed" form of carnitine deficiency with the elements of both systemic and myopathic carnitine deficiency. The older sibling died suddenly after a 24-hour fast. The younger boy has received carnitine for three years. During this period, serum CPK activity has remained elevated and increased further during illnesses, but no clinical symptoms of encephalopathy or myopathy have appeared.

Carnitine↗

PubMed1980

Encephalopathy in children with chronic renal failure.

Progressive encephalopathy with characteristic clinical features and electroencephalographic findings has been reported many times in adult patients treated with maintenance hemodialysis. Two children with chronic renal failure developed a similar encephalopathy prior to their second birthdays and before the initiation of dialysis. Both children required parathyroidectomy for control of severe hyperparathyroidism with persistent hypercalcemia. Slight improvement followed this procedure in one patient. Selected biochemical abnormalities in serum and in brain tissue specimens were compared to those of neurologically unaffected children. Results of thes studies suggest that a direct toxic effect of either aluminum or calcium on the brain does not play an etiologic role in this disorder.

Aluminum↗

PubMed1979

Serum concentrations of 25-hydroxyvitamin D in Florida children: effect of anticonvulsant drugs.

The mean serum concentration of 25-hydroxyvitamin D (25OHD), determined by nonchromatographic radioassay, was significantly lower (P less than .02) in Florida children with epilepsy treated with anticonvulsant drugs (34.4 +/- 11.3 [SD] ng/ml) than in normal subjects (40.9 +/- 14.3), despite exposure of both groups to sunlight throughout the year. In 12% of children treated with anticonvulsant drugs, the 25OHD level was below the lowest value recorded in the control group. The mean serum concentration of 25OHD in normal Philadelphia children (27.5 +/- 9.1 ng/ml) was significantly less than in either group of Florida subjects. Annual monitoring of calcium homeostasis and vitamin D status is indicated in Southern children receiving anticonvulsant drugs, but routine vitamin D supplementation of such patients is unnecessary.

Anticonvulsants↗

PubMed1977

The electroencephalogram in neglect.

The extent of electroencephalographic (EEG) abnormalities in 23 consecutive patients with unilateral neglect was compared with the extent of EEG abnormalities in 20 matched aphasic controls. In the neglect group, 22 patients showed EEG slowing that extended over the entire hemisphere. In the control group only 8 patients showed similar hemispheric slowing. This study demonstrates that patients with unilateral neglect from discrete lesions may have EEG slowing in regions of the hemisphere that are remote from the lesion. This study also provides support for the hypothesis that neglect is a unilateral arousal defect.

Animals↗

PubMed1976

Nevus unius lateralis and brain tumor.

A patient with linear nevi of the right side of the neck had right hemiparesis of gradual onset. At surgery, a "mixed glioma" was removed from the left parietal region.

Adolescent↗

PubMed1975