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Biomedical subjects

M Angelo

Publications and source records attributed to M Angelo.

At least 19 recordsLinked to original sources
PubMed1998

[Meaning of the health concept from the perspective of families at personal and social risk].

The purpose of this study is to describe the meaning of health through the perspective of families under personal and social risk situations. The ethnographic analysis based the investigation and data were collected through interviews with the low income families of children attended by a Communitary Center in São Paulo city. The analysis of the interview contents allowed the identification of 7 cultural domains. The results of this study show the characteristics of knowledge, values and behaviours about the health concept, that are relevant to families, enabling the understanding of the family organization, that is significant to health care of each member and also the central role carried out by mothers in the studied culture.

Adult↗
PubMed1995

[From experience to science: the evolution of nursing knowledge].

The aim of this paper is to show the evolution of the nursing knowledge. Some relations with the nursing history are proposed, in order to indicate the ways the people and ideas of today in nursing was influenced by the past. The authors make a correlation between the development of the nursing as profession and of the nurse as professional.

Education, Nursing↗
PubMed1983

Synthesis and antifilarial activity of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]- 2-pyrimidinyl]-N'-phenylguanidines.

A series of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]- 2-pyrimidinyl]-N'-phenylguanidines have been synthesized for antifilarial evaluation. Reaction of the appropriate benzenamines with N-cyanoguanidine, followed by condensation of the resultant N-phenylimidodicarbonimidic diamides (V) with ethyl 4,4,4-trifluoro-3-oxobutanoate provided the intermediate N-(4-hydroxy-2-pyrimidinyl)-N'-phenylguanidines VIa. Alternatively, compounds VIa were synthesized by reaction of the requisite beta-keto esters (VII) with N-cyanoguanidine to give the (4-hydroxy-2-pyrimidinyl)cyanamides (VIII), followed by treatment with the desired benzenamines. Chlorination with POCl3 and condensation with the appropriate benzenamines (IX) generated the desired guanidines (X). Antifilarial activity was confined to adult Litomosoides carinii infections, and a structure-activity relationship for this activity is discussed. Lack of activity against L. carinii microfilaria and adult Brugia pahangi infections preclude further work in this area pending evaluation in additional experimental models.

Animals↗