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Biomedical subjects

M Anstead

Publications and source records attributed to M Anstead.

4 recordsLinked to original sources

Pediatric sleep disorders: new developments and evolving understanding.

Disorders of sleep in children are distinctly different from sleep disorders in adults. Since children are forced to constantly learn and adapt, the effects of disordered sleep may be more profound. This paper reviews the disorders of sleep that are most significant in each of the stages of development from infancy to adulthood. Recent literature pertaining to advances in the diagnosis and treatment of sudden infant death syndrome and obstructive sleep apnea syndrome in children are highlighted. In addition, recent literature on the relationship of behavior and learning problems to sleep disorders is examined.

Adolescent↗

The spectrum of sleep-disordered breathing.

The term sleep-disordered breathing has been used synonymously with the term obstructive sleep apnea syndrome (OSAS). In a broader sense, however, the disorders of breathing during sleep exist along a spectrum of severity. The mildest form of sleep-related breathing disorder is intermittent snoring, which is primarily a nuisance without significant health sequelae. The most severe form of disordered breathing is the obesity-hypoventilation syndrome, which is associated with severe morbidity and very high mortality. In between these two extremes are disorders of gradually increasing impact on morbidity and mortality: persistent snoring, upper airway resistance syndrome, and OSAS.

Age Factors↗

Tolerance and intolerance to continuous positive airway pressure.

Nasal continuous positive airway pressure (CPAP) is the most effective and widely used therapy for obstructive sleep apnea. As with any chronic therapy, long-term compliance has a significant impact on its effectiveness. Only about half of patients use CPAP for more than half the night on five or more nights per week. Approximately 4 hours of CPAP therapy per night appears to significantly improve daytime alertness and performance. Four hours of therapy also seems to improve sleep-disordered breathing for the remainder of the night. Patient education and close follow-up and intervention appear to improve long-term tolerance. Autotitration CPAP or bilevel positive airway pressure systems are no more effective or better tolerated than conventional CPAP therapy. They may be useful options if patients have been unable to tolerate conventional CPAP therapy.

Female↗

Tetralogy of Fallot with absent pulmonary valve and bronchial compression: treatment with endobronchial stents.

Absent pulmonary valve syndrome (APVS) is a rare congenital cardiac lesion. The lesion includes ventricular septal defect, overriding aorta, and absence of the pulmonary valve, with resultant pulmonary incompetence. It has been suggested that the pulmonary incompetence induces intrauterine dilatation of the pulmonary artery, which leads to tracheobronchial compression. One of the presenting features in infants with APVS is severe airway obstruction, which may be difficult to manage. We report an infant who benefited from bilateral endobronchial endoscopic stent placement.

Bronchial Diseases↗