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M Anthony Pogrel

Publications and source records attributed to M Anthony Pogrel.

18 recordsLinked to original sources
PubMed2007

Damage to the inferior alveolar nerve as the result of root canal therapy.

BACKGROUND: Endodontic treatment of mandibular molar teeth has the potential to damage the inferior alveolar nerve via direct trauma, pressure or neurotoxicity. METHODS: The author reviewed all cases of involvement of the inferior alveolar nerve resulting from root canal therapy in patients seen in a tertiary referral center during an eight-year period (1998 through 2005). The author had encouraged practitioners to refer patients immediately to a university clinic. RESULTS: The author saw 61 patients during the eight-year period. Eight patients were asymptomatic and received no treatment. Forty-two patients exhibited only mild symptoms or were seen more than three months after undergoing root canal therapy, and they received no surgical treatment. Only 10 percent of these patients experienced any resolution of symptoms. Eleven patients underwent surgical exploration. Five of these patients underwent exploration and received treatment within 48 hours, and all recovered completely. The remaining six patients underwent surgical exploration and received treatment between 10 days and three months after receiving endodontic therapy. Of these patients, four experienced partial recovery and two experienced no recovery at all. CONCLUSIONS: Early surgical exploration and débridement may reverse the side effects of endodontic treatment on the inferior alveolar nerve. CLINICAL IMPLICATIONS: If the radiograph obtained after endodontic therapy shows sealant in the inferior alveolar canal, then immediate referral to an oral and maxillofacial surgeon is indicated if the patient has continued symptoms of paresthesia or pain once the local anesthetic should have worn off. Immediate surgical exploration and débridement may provide satisfactory results.

Debridement↗
PubMed2006

Reconstruction of perioral defects following resection for oral squamous cell carcinoma.

PURPOSE: The aim of this study was to review and describe techniques for the reconstruction of large, complex perioral defects after resection of oral squamous cell carcinoma with emphasis on cosmetic and functional outcome. PATIENTS AND METHODS: A review of techniques and selected case presentations using different flap designs for the reconstruction of large perioral defects following resection of squamous cell carcinoma was performed. The Bernard and Karapandzic flaps were used for large lower lip defects. A Zisser flap technique was used to reconstruct a large commissure defect. RESULTS: All reconstructed patients had acceptable functional results and healed without complication. The large lower lip defects were easily closed with the Bernard and Karapandzic flaps. The commissure defect was reconstructed using the Zisser technique. While cosmesis was acceptable in all cases, the commissure was the most difficult region to reconstruct with a favorable appearance. There were no flap failures. The Karapandzic flap led to greater rounding of the commissure area and the composite resection resulted in a lack of lower lip support that was improved with prosthesis. Function was noted to be excellent in the Bernard and Karapandzic flaps, with the patients able to purse lips and blow up balloon-type devices. CONCLUSION: The Bernard, Karapandzic, and Zisser flaps provide a predictable method to reconstruct large perioral defects following resection for oral cancer. Subsequent fabrication of a prosthesis can aid in lip support for the resected area.

Aged, 80 and over↗
PubMed2006

Ameloblastoma: a surgeon's dilemma.

PURPOSE: To investigate whether there were any significant differences in the mode of presentation, treatment, and outcome of patients presenting with a primary diagnosis of ameloblastoma in Glasgow, Scotland and San Francisco, CA. MATERIALS AND METHODS: All cases of ameloblastoma seen in both institutions between January 1, 1980 and December 31, 1999 were included in this study. Mode of presentation, radiographic appearance, histologic appearance, treatment, and follow-up were recorded. RESULTS: There were no significant differences in the clinical features on presentation (swelling, followed by pain, and altered sensation), the radiographic appearance (unilocular approximately 30% and multilocular 70%), or management with either local treatment (enucleation and/or curettage in just over 50% of cases) or radical treatment (a form of resection in under 50%) in the 50 cases included in this study. Primary care by conservative treatment led to a recurrence in approximately 80% of cases and this included cases of unicystic ameloblastoma. CONCLUSION: The mode of presentation, diagnosis, and management of the ameloblastoma was remarkably similar in Glasgow and San Francisco. The recurrence rate following local enucleation and curettage was unacceptably high, and this included the cases of unicystic ameloblastoma, which should be treated more aggressively than has been recommended in the past.

Adolescent↗
PubMed2006

Etiology of lingual nerve injuries in the third molar region: a cadaver and histologic study.

PURPOSE: It has been suggested that different etiologies of lingual nerve damage in the third molar area will produce a different clinical and histologic appearance in the nerve. If the clinical and histologic pictures were different, it could result in different treatments being recommended. MATERIALS AND METHODS: Eight preserved cadavers (16 lingual nerves) were used for this study. As far as possible, the nerves were left in situ and damaged in a way that could be envisaged during third molar surgery. In each case, the damaged sections of nerve were photographed, resected, embedded in paraffin wax, sectioned in 5 mum sections, stained with hematoxylin-eosin, and examined histologically. RESULTS: The scalpel clinically produced a clean wound with sharply defined edges; this was confirmed histologically with minimal disruption to the fascicles. The 702 fissure bur produced a ragged stretch-type injury clinically, and histologically this was confirmed with an irregular-edged border to the lesion and stretching and internal damage to the fascicles immediately adjacent to the wound. The crush injury clinically caused considerable apparent damage to the nerve, which was confirmed histologically with crushing and disruption of the fascicles and reduction to approximately 25% of their preinjury thickness. The stretch injury clinically showed no damage, but histologically showed irregular internal disruption of the fascicles over the whole area subject to stretching movements. CONCLUSION: It does appear that different modalities in nerve injury produce a different type of injury both clinically and histologically. This information has implications for both natural clinical recovery and the indications for surgical intervention. Clinical recovery may occur best with close approximation of a sharp scalpel-type wound or excision of a crushed area of nerve with reapproximation of the nerve endings, but a ragged wound caused by a fissure bur may require excision back to healthy nerve with subsequent reapproximation, whereas with the stretching injury it may be difficult to ascertain the edges and limits of the wound, and difficult to repair, and it may be most appropriate to rely on a natural healing process for the best results.

Cadaver↗
PubMed2005

Preoperative autologous blood donation for oral and maxillofacial surgery: an analysis of 913 patients.

PURPOSE: Autologous transfusions are frequently used with elective surgical procedures and are a mandated choice under California law. Because unused units cannot be transfused to other patients, it is important to assess utilization and minimize waste. METHODS: The transfusion needs of 913 consecutive patients scheduled for major oral and maxillofacial surgery at the University of California San Francisco were evaluated in 3 categories: oncologic and reconstructive surgery (563), orthognathic surgery (260), and temporomandibular joint surgery (90). RESULTS: 24.9% of patients chose to undergo preoperative autologous blood donation. 24.2%, 20.6%, and 11.4% of oncologic and reconstructive surgery, orthognathic surgery, and temporomandibular joint surgery patients, respectively, who made an autologous donation preoperatively, subsequently received a transfusion postoperatively. CONCLUSION: Transfusion needs for most oral surgery procedures are clearly overestimated; the relatively low risk of blood loss associated with these procedures today should be taken into account when asking patients to participate in preoperative autologous blood donation.

Adolescent↗
PubMed2005

Frequency of trigeminal nerve injuries following third molar removal.

PURPOSE: To estimate oral and maxillofacial surgery reporting of the frequency of temporary and permanent inferior alveolar and lingual nerve damage from lower third molar extraction and injury etiology, and to identify factors associated with injury rates. MATERIALS AND METHODS: A postal survey was sent to all members of the California Association of Oral and Maxillofacial Surgeons requesting information on known instances of inferior alveolar and lingual nerve damage that had occurred in their practices over a 12-month period and known instances of permanent damage over their entire careers. RESULTS: Replies were obtained from 535 California Oral and Maxillofacial Surgeons (OMFS) representing 86% of all OMFS in California. Instances of injury to the inferior alveolar nerve in a 12-month period were reported by 94.5% of OMFS; 53% reported instances of lingual nerve injury in a 12-month period. Instances of permanent nerve injury of the inferior alveolar nerve were reported by 78% of OMFS; 46% reported permanent lingual nerve injury occurring during their professional lifetime. The overall estimated self-reported rate of injury was 4 per 1,000 lower third molar extractions for the inferior alveolar nerve and 1 per 1,000 extractions for the lingual nerve for all cases (temporary and permanent). In most cases (80%) of inferior alveolar nerve injury the cause was known, but in a majority of cases of lingual nerve injury (57%) the injury etiology was unknown. Self-reported rates of permanent injury were 1 per 2,500 lower third molar extractions for the inferior alveolar nerve and 1 per 10,000 lower third molar extractions for the lingual nerve. Injury rates were associated with provider experience (ie, extractions per year) and years in practice. CONCLUSION: This survey included a high percentage of California OMFS. Injury to the inferior alveolar and lingual nerve was reported by most OMFS in California following lower third molar removal, and many reported cases of permanent nerve injury, frequently with unknown cause.

California↗
PubMed2004

Marsupialization as a definitive treatment for the odontogenic keratocyst.

PURPOSE: We sought to show that marsupialization can be a definitive treatment for the odontogenic keratocyst (OKC). MATERIALS AND METHODS: Ten patients (10 males and 4 females) between the ages of 11 and 64 with biopsy-proven OKC (8 mandibular and 2 maxillary) measuring between 2 and 8 cm were treated by marsupialization consisting of excision of the overlying mucosa and the opening of a 1-cm window into the cystic cavity and, where possible, suturing of the cyst lining to the oral mucosa. Immunohistologic determination of bcl-2 was done for all samples of cyst lining. The cavities were kept open either by vigorous use of a home syringe by the patient or by suturing into place the flange and short length of a nasopharyngeal airway. Once the cyst had largely filled in, histologic material was taken from the base of the residual depression and studied by light microscopy and bcl-2 expression. RESULTS: In the 10 patients, the OKCs completely resolved both clinically and radiographically. The time taken for resolution varied from 7 to 19 months. In all cases, the histologic material obtained after marsupialization showed normal epithelium only, with no signs of cystic remnants, daughter cysts, or budding of the basal layer of the epithelium. At initial biopsy, bcl-2 was expressed in the keratocyst lining, but not in the histologic material obtained after marsupialization. Follow-up time ranged from a minimum of 1.8 years to a maximum of 4.8 years. Teeth at the periphery of the cysts were observed to upright and erupt. CONCLUSIONS: All 10 OKCs resolved completely after marsupialization. Teeth within the cyst were found to be upright and erupt. Marsupialization requires a cooperative patient who will irrigate the cavity and keep it open. It appears that the cyst lining is replaced by normal epithelium during this treatment.

Adolescent↗
PubMed2004

Lingual flap retraction for third molar removal.

PURPOSE: Lingual nerve damage following lower third molar surgery remains a clinical problem. The traditional approach in the United States has been a buccal approach avoiding exposure or surgery on the lingual side of the crest of the ridge. An alternative technique is to deliberately expose the lingual tissues and retract the lingual nerve lingually before tooth removal. This study reports a trial of this technique. MATERIALS AND METHODS: Patients had removal of their lower third molars carried out using a technique that raises a lingual flap in addition to a buccal flap and places a specially designed lingual retractor to ensure that the lingual nerve is held out of the surgical field. This technique was used in cases where the crown of the tooth had to be sectioned or when distal bone needed to be removed. RESULTS: Two hundred fifty patients were treated by this method. There were 4 cases of transient lingual paresthesia, presumably caused by traction pressure from the retractor. Three of these cases were mild and resolved within 3 weeks. The fourth case had more profound paresthesia, but still resolved within 2 months. There were no cases of permanent nerve damage, and in many cases removal of the third molar was simplified by the superior access. CONCLUSION: Lingual retraction for third molar removal improves access to the surgical site and can simplify third molar removal. In this prospective study there were no cases of permanent lingual nerve injury.

Alveolectomy↗
PubMed2004

Coronectomy: a technique to protect the inferior alveolar nerve.

PURPOSE: Damage to the inferior alveolar nerve when extracting lower third molars is often caused by the intimate relationship between the nerve and the roots of the teeth. The technique of coronectomy, or intentional root retention, may minimize this problem. PATIENTS AND METHODS: Forty-one patients underwent coronectomy on 50 lower third molars with follow-up of at least 6 months. The technique of coronectomy deliberately protected the lingual nerve as part of the surgical procedure. All roots were left at least 3 mm below the buccal and lingual plates of bone. All patients were radiographed preoperatively, immediately postoperatively, and after 6 months. RESULTS: There were no cases of inferior alveolar nerve-involved damage in this study of 41 patients who underwent 50 coronectomies. There was 1 case of transient lingual nerve involvement, probably from the use of the lingual retractor. One patient required subsequent removal of the roots of both lower third molars because of failure to heal, and 1 patient required subsequent removal of a root because of subsequent migration to the surface. Root migration was noted in approximately 30% of patients over a 6 month period. CONCLUSION: Coronectomy appears to be a viable technique in those cases where removal of the whole tooth might put the inferior alveolar nerve at considerable risk of damage. The technique appears to be associated with a low incidence of complications, but subsequent migration of the roots may be an issue in the long term.

Cranial Nerve Injuries↗
PubMed2003

The expression of apoptotic proteins and matrix metalloproteinases in odontogenic myxomas.

PURPOSE: The odontogenic myxoma is a rare benign tumor affecting the jaws. We hypothesize that odontogenic myxomas have dysregulated antiapoptotic mechanisms to assist in neoplastic growth. We believe that antiapoptotic proteins of the Bcl-2 family are over expressed and that tumor cells must generate some form of matrix proteinase. The aim of this study was to evaluate odontogenic myxomas for the expression of cell cycle protein Ki-67, apoptosis-regulating proteins Bcl-2, Bcl-XL, Bak, and Bax, and matrix metalloproteinases MMP-2, MMP-3, and MMP-9. MATERIALS AND METHODS: Odontogenic myxomas submitted to oral pathology between 1974 and 1998 were evaluated. Twenty-six paraffin-embedded tissue sections were used in a standard immunohistochemistry protocol and incubated with one of the following antibodies: Bcl-2, Bcl-XL, Bak, Bax, or Ki-67. The sections were then incubated with anti-immunoglobulin conjugated to peroxidase-labeled dextran polymer in a Tris-HCl buffer. Counts of positive (staining) cells were completed in 5 high-power fields for each specimen. Each slide was reviewed by 2 investigators, and final data were pooled and averaged. RESULTS: Specimen slides showed an increase in cells staining positively for anti-apoptotic proteins Bcl-2 and Bcl-X. An average of 6.5% of specimen cells were positive for Bcl-2 and 10.4% for Bcl-X. Control tissue showed only 1.1% of cells to be positive for Bcl-2 and 1.2% for Bcl-X. Less than 1% of both specimen and control cells stained positively for Ki-67. Proapoptotic proteins (Bak and Bax) were not detected in tumor cells. Ninety percent of tumor cells stained positively for MMP-2 compared with 10% of controls. Specimen and controls were negative for MMP-3 and MMP-9. CONCLUSION: Odontogenic myxoma tumor cells did not show an increase in cell division. Less than 1% of tumor and control cells were positive for Ki-67. Odontogenic myxoma tumor cells showed increased expression of antiapoptotic proteins (Bcl-2 and Bcl-X) and the matrix metalloproteinase MMP-2. This study suggests that 2 mechanisms of disease progression used by the odontogenic myxoma are the production of antiapoptotic proteins and the secretion of matrix metalloproteinases.

Adolescent↗
PubMed2003

The role of tongue reduction.

Macroglossia may occur as a congenital or acquired condition. The enlarged tongue has both functional and cosmetic deformity, which may affect the oral airway, speech, and the development of the jaws. We discuss the various tongue-reduction procedures and present cases to illustrate the uses of this procedure, its potential complications, and the results.

Adolescent↗
PubMed2003

Lingual nerve damage due to inferior alveolar nerve blocks: a possible explanation.

BACKGROUND: An explanation for the predominance of injuries to lingual nerves over those to inferior alveolar nerves as a result of inferior alveolar nerve blocks may be due to the nerves' fascicular pattern. A unifascicular nerve may be injured more easily than a multifascicular nerve. METHODS: The authors unilaterally dissected lingual and inferior alveolar nerves from 12 cadavers. They cut the specimens 2 millimeters above the lingula for both the lingual nerve and inferior alveolar nerve and opposite the site of the middle of the third molar for the lingual nerve, and they counted the number of fascicles at each site. RESULTS: For the lingual nerve at the lingula, the mean number of fascicles was three (range, one to eight). Four of the 12 nerves (33 percent) were unifascicular at this point. Opposite the third molar, the lingual nerve had a mean of 20 fascicles (range, six to 39). In every case, there were more fascicles in the third molar region than above the lingula in the same nerve. At the lingula, the inferior alveolar nerve had a mean of 7.2 fascicles (range, three to 14). CONCLUSION: This study may explain the observation that when an inferior alveolar nerve block causes permanent nerve impairment, the lingual nerve is affected about 70 percent of the time and the inferior alveolar nerve is affected only 30 percent of the time. In 33 percent of cases, the lingual nerve had only one fascicle at the lingula; a unifascicular nerve may be injured more easily than a multifascicular one. CLINICAL IMPLICATIONS: There is no known way to avoid the remote possibility of nerve damage resulting from an inferior alveolar nerve block. The lingual nerve may be predominantly affected because of its fascicular pattern.

Anesthesia, Dental↗
PubMed2002

The results of microneurosurgery of the inferior alveolar and lingual nerve.

PURPOSE: The goal was to evaluate the experience of one surgical unit during a 5-year period in the evaluation and management of patients with injuries of the inferior alveolar and lingual nerve with particular reference to indications for and results of microneurosurgery. PATIENTS AND METHODS: This study includes all patients referred with a diagnosis of injury to the inferior alveolar or lingual nerve during 5-year period from January 1, 1994, to January 1, 1999. All patients were evaluated with Frey's hairs for touch and direction sense, 2-point discrimination, and hot and cold water and Minnesota thermal discs for temperature sensation. Patients who fulfilled certain specified criteria were offered microneurosurgery, and the results were evaluated for those who underwent microneurosurgery. RESULTS: The study consisted of 880 consecutive patients; 96 were thought to fulfill the criteria for microneurosurgery. Of these, 51 underwent microneurosurgical exploration and repair. In 5 patients, no injury could be detected at surgery, and no corrective surgery was performed other than decompression. In 26 patients, excision and direct anastomosis were performed, and in an additional 20 patients, nerve gap reconstruction was performed. In 16 of these 20 patients, reconstruction was performed with an autogenous vein graft, and in 2 patients, a Gore-Tex tube graft (W.L. Gore & Associates, Inc, Flagstaff, AZ) was used to bridge the nerve gap. In 2 patients, an autogenous nerve was used. Thirty-four of the repairs were made on the lingual nerve, and 17 were made on the inferior alveolar nerve. With the use of established criteria, 10 patients were considered to have had a good improvement in sensation, 18 patients were considered to have had some improvement in sensation, and 22 patients were considered to have had no improvement in sensation; 1 patient reported an increase in dysesthesia after surgery. The semiobjective assessment of patients did not always correspond with the patients' subjective evaluation. CONCLUSION: In a relatively small study in selected cases, microneurosurgery can provide a reasonable result in improving sensation in the inferior alveolar and lingual nerve. More than 50% of patients experienced some improvement in sensation, and dysesthesia did not develop after surgery in any patient who did not have it before surgery.

Female↗
PubMed2002

OMS baby bust?

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Female↗