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Biomedical subjects

M Ara

Publications and source records attributed to M Ara.

At least 19 recordsLinked to original sources
PubMed2006

Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patients.

BACKGROUND: The clinical diagnosis of dermatofibroma is commonly easy. However, the differentiation of dermatofibroma from other cutaneous tumours is difficult in some instances, primarily in atypical cases and rare variants. Haemosiderotic dermatofibroma is a variant composed of numerous small vessels, extravasated erythrocytes and intra- and extracellular haemosiderin deposits. Aneurysmal dermatofibroma is a variant composed of large, blood-filled spaces without endothelial lining. Some authors consider that haemosiderotic dermatofibroma is an early stage in the development of aneurysmal dermatofibroma. The clinical differential diagnosis of haemosiderotic or aneurysmal dermatofibroma must include melanoma and other melanocytic tumours, vascular neoplasms, adnexal tumours and nonspecific cysts. Dermoscopy improves the diagnostic accuracy in pigmented and nonpigmented skin lesions. OBJECTIVES: To evaluate specific dermoscopic criteria. METHODS: Dermoscopic examination (using the DermLite Foto; 3Gen, LLC, Dana Point, CA, U.S.A.) of six patients with haemosiderotic or aneurysmal dermatofibromas was performed to evaluate specific dermoscopic criteria. RESULTS: A multicomponent pattern with a central bluish or reddish homogeneous area in combination with white structures and a peripheral delicate pigment network along with vascular structures was noted in five of six lesions. CONCLUSIONS: This dermoscopic pattern yielded the diagnosis of haemosiderotic or aneurysmal dermatofibroma in most cases. However, this multicomponent pattern may present in some melanomas and although it is useful in determining a clinical diagnosis of aneurysmal dermatofibroma, it may not be specific to this entity.

Adult↗
PubMed2002

Effect of blending calcium compounds on hydrolytic degradation of poly(DL-lactic acid-co-glycolic acid).

To clarify the effect of blending calcium compounds with different acidity or basicity on the degradation of poly(DL-lactic acid-co-glycolic acid) (PLGA). composite materials composed of PLGA incorporated with 30 mass% of calcium dihydrogenphosphate (CDHP), calcium hydrogenphosphate, calcium phosphate, and calcium carbonate (CC) were prepared by mixing in dioxane followed by freeze-drying. The porous composite materials were then compressed to yield nonporous films with 0.5 mm thickness. The blend films and the unfilled films as a control were immersed in phosphate-buffered saline (pH 7.4) at 37 degrees C. Specimens were removed at 1, 2, 3, 4, 6, and 8 weeks and subjected to measuring of water absorption, mass loss, thickness change, and molecular weight. The temporal changes in appearance and measurements for the five materials differed from each other; especially, the CC blend differed from the other four materials. The degradation of PLGA decreased with increasing basicity of the calcium compounds blended. The most basic CC was most effective to delay the degradation, while the most acidic CDHP was least effective. However, even CDHP had appreciable degradation-delaying effects compared with unfilled PLGA. Thus, the findings of the present study suggest that degradation of PLGA can be varied by blending inorganic compounds with different basicity.

Biocompatible Materials↗
PubMed2002

Recurrent lentigo maligna as amelanotic lentigo maligna melanoma.

Amelanotic lentigo maligna and lentigo maligna melanoma are extremely rare tumours. Even rarer is a recurrent amelanotic lentigo maligna or amelanotic lentigo maligna melanoma at the site of a previously removed pigmented lentigo maligna. We describe two cases of recurrent amelanotic lentigo maligna melanoma manifesting as erythematous plaques evolved from previously excised pigmented lentigo maligna.

Aged↗
PubMed2001

Age-related hypermethylation of the hMLH1 promoter in gastric cancers.

To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestinal metaplastic tissues adjacent to cancers with hypermethylation did not exhibit any hMLH1 methylation, indicating that it may be specific to gastric cancers. The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people.

Adaptor Proteins, Signal Transducing↗
PubMed2000

Primary tuberculous chancre caused by Mycobacterium bovis after goring with a bull's horn.

A 14-year-old boy was gored by a bull during festival celebrations. The horn of the bull caused a wound on his left hand and after 3 months it was a accompanied by an ulcerated nodule on the left upper arm and an axillary adenopathy. The tuberculin test was positive and a culture of the aspiration biopsy specimen of the axillary lymph node yielded Mycombacterium bovis.

Adolescent↗
PubMed1998

Visceral leishmaniasis with cutaneous lesions in a patient infected with human immunodeficiency virus.

We report a case of visceral leishmaniasis (VL) with cutaneous lesions in a patient infected with human immunodeficiency virus (HIV). The cutaneous lesions consisted of erythematous papules on the legs. Biopsy of one lesion showed abundant Leishmania amastigotes within epithelial cells of an eccrine sweat gland in the dermis. Leishmania organisms were also found in a blood smear. Rapid and complete clearance of the cutaneous lesions was achieved after antimony therapy. Cutaneous lesions in VL are being reported increasingly frequently in patients with HIV infection and their significance remains in discussion.

AIDS-Related Opportunistic Infections↗
PubMed1991

A thrombin ointment that achieves rapid haemostasis of split thickness donor wounds, particularly on the scalp.

A procedure is described to achieve rapid haemostasis of split thickness donor wounds by using an ointment containing thrombin (10,000 units mixed in 10 g of petroleum jelly-based gentamicin ointment). The ointment, prepared just before the removal of the skin graft, is immediately spread over the wound after the graft has been taken. With this technique, a steady haemostasis is promptly and simply achieved without the recurrence of bleeding compared to the technique using only a thrombin solution (bleeding time: a mean of 11.5 s for the thrombin ointment and 25.5 s for the thrombin solution, P less than 0.01). Thus, particularly when many skin grafts are needed, further skin grafts from adjacent areas can be readily taken without interference by bleeding. This procedure has proved to be extremely useful in achieving rapid haemostasis of split thickness skin donor wounds, especially when taking skin grafts from the scalp.

Administration, Topical↗
PubMed1990

Treatment of dermal depth burn wounds with an antimicrobial agent-releasing silicone gel sheet.

Silicone gel sheets containing 0.02 per cent Ofloxacin were used in the treatment of 24 patients with a total of 27 dermal depth burn wounds. The gel provided a continuing drug delivery system from the dressing to the wound. Clinically the silicone gel sheets did not adhere to the wound and could be removed easily without pain. No infection developed in any of the dermal depth burn wounds treated with the gel sheets. The silicone gel sheets were found to promote prompt epithelialization in 16 burn wounds of superficial dermal depth (mean 8.4 days) compared with ointment-impregnated gauze dressings (mean 14 days, P less than 0.01). There was less pain and discharge by macroscopic observation of the absorbent materials from both dressings. In nine wounds of mixed superficial and deep dermal burn, the silicone gel also provided prompt epithelialization (mean 12 days) compared to the control wounds (mean 22 days, P less than 0.01).

Adolescent↗
PubMed1990

Experiences using silicone gel tie-over dressings following skin grafting.

Twenty-six patients with 27 skin grafts treated with tie-over dressings using silicone gel sheets containing 0.02 per cent Ofloxacin are described. This method ensured direct in-progress inspection of healing of the grafted skin. Although the silicone gel tie-over procedure without any additional pressure resulted in haematoma and congestion in four out of 12 grafts (33.3 per cent), in the group with additional pressure (approximately 20-30 mmHg) limited to the early period after surgery there was no haematoma and congestion of the grafts in 15 grafts (P less than 0.05, Chi-square test). It is surmised that adequate pressure applied to the graft for a few days after surgery would be beneficial in preventing haematoma formation.

Adolescent↗
PubMed1990

Expanding oral angle plasty using a subcutaneous pedicle flap to correct severe microstomia after extensive facial burns.

Expanding oral angle plasty using a subcutaneous pedicle flap to correct severe microstomia due to extensive facial scar contractures is described. This technique is especially suited for the elderly, who are unable to tolerate large skin grafting of the face, and for patients with insufficient normal donor skin to undertake extensive correction of scar contractures.

Age Factors↗
PubMed1989

Refinement of the scrap technique of skin grafting.

A technique to obtain a sheet of meshed skin by assembling many small skin grafts is described. The merits of this technique are that a meshed skin graft of desired size and shape is obtained using many small pieces of skin, and moreover, these pieces of skin do not break down when meshed or when applied to the recipient bed, since the graft is reinforced by a plastic film. Graft survivals and epithelialization of the wound are excellent. This technique is especially useful in extensively burned patients with a limited and scattered donor area, and also for patients who require stamp grafts but are not cooperative enough to keep still for prolonged periods after surgery.

Burns↗
PubMed1988

Bilateral vermilion flap. A modification of Goldstein's technique.

A bilateral tissue expanding flap is described for the reconstruction of the mid-vermilion border. With this technique, a defect of about one-half of the vermilion border can be reconstructed with little discomfort to the patient. Because of the high degree of tissue extensibility, this procedure appears to be a versatile one especially in elderly people.

Aged↗
PubMed1988

[Concentrations of cefuroxime in the skin].

Concentrations of cefuroxime (CXM) in the skin and the serum of 24 patients were examined. CXM (0.75 g, 1.5 g) was administered to these patients intravenously in one shot. The skin and the serum were collected at 30 and 60 minutes after the injection. Concentrations of CXM in the skin were following: 0.75 g, 30 min.; 11.4 +/- 5.3 micrograms/g 60 min.; 9.5 +/- 4.7 micrograms/g 1.5 g, 30 min.; 17.1 +/- 6.8 micrograms/g 60 min.; 15.7 +/- 13.2 micrograms/g Concentration ratios (skin/serum) at 60 minutes after the injection were from 72.5% to 79.2%. The binding ratio of CXM to serum protein was 41%, which was lower than most other antibiotics. High concentration levels of CXM were maintained in the skin for a long time. Based on this study, we consider that CXM is effective in the skin surgery.

Cefuroxime↗
PubMed1987

Posterior commissural connections of area pretectalis and neighboring structures in cat, with special reference to pupilloconstrictory pathway via posterior commissure.

The overall distribution of posterior commissural connections of the area pretectalis and the neighboring structures was studied in the cat, by the methods of anterograde fiber degeneration and retrograde axonal transport of horseradish peroxidase (HRP). After a localized lesion was made within the posterior commissure, dense degenerated terminals were distributed in the most rostral part of the nucleus pretectalis posterior, the nucleus of posterior commissure, the interstitial nucleus of Cajal, and the central tegmental field. A medium amount of degenerated terminals were observed in the nucleus pretectalis anterior (pars reticularis), the dorsal part of the periaqueductal grey at its most rostral levels, the caudolateral parts of the nucleus pretectalis posterior and the nucleus of optic tract, the H field of Forel, parts of the somatic cell columns of the oculomotor nucleus and the trochlear nucleus. A small amount of degenerated terminals were seen in the ventromedial part of the caudal periaqueductal grey, the ventral lateral geniculate nucleus and the zona incerta. However, the amount of degenerated terminals was very small in the nucleus pretectalis medialis and the nucleus pretectalis olivaris. Following an HRP (dissolved in 5% alkyl-phenol ethylene oxide) injection into the unilateral area pretectalis where fibers of the posterior commissure fan out, retrogradely labeled cells were observed in all of the above described (posterior commissural fiber recipient) regions of the pretectal and neighboring structures, with the exception of the somatic cell columns of the oculomotor nucleus and the trochlear nucleus. The number of labeled cells appeared roughly proportional to the amount of degenerated terminals of the posterior commissural fibers described above with the apparent exception of the nucleus pretectalis anterior, pars reticularis, where only a few labeled cells were identified. The findings were discussed with special reference to the pupilloconstrictory pathway via the posterior commissure.

Animals↗