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Biomedical subjects

M Arató

Publications and source records attributed to M Arató.

At least 91 records · Page 5Linked to original sources
PubMed1982

Neuroendocrine study of the mechanism of action of electroconvulsive therapy.

The authors' earlier studies indicated that prolactin (PRL) response to electroconvulsive therapy (ECT) was not the result of stress reaction, because the secretion of other stress-sensitive hormones showed no parallel increase. The results of the present investigation are consistent with this findings as diazepam pretreatment failed to influence the PRL response induced by ECT. The rise of the serum PRL level was accompanied by a slight but significant decrease of the serum dopamine-beta-hydroxylase activity. A significant negative correlation was found between baseline serum dopamine-beta-hydroxylase activity and PRL response. These data indicate a correlation between serum dopamine-beta-hydroxylase activity and central dopaminergic function. PRL response to ECT is supposed to be the result of the dopaminergic action of ECT.

Adult↗
PubMed1982

Depression and diabetes mellitus. A study of the relationship between serum cortisol and blood sugar levels in patients with endogenous depression.

The relationship between serum cortisol and fasting blood sugar levels in 39 female patients with endogenous depression was studied. Serum cortisol levels were determined in two post-dexamethasone blood samples during the dexamethasone suppression test. There were no significant differences between the blood sugar levels of suppressors (patients with low serum cortisol level) and non-suppressors (patients with high serum cortisol level). There was no correlation between the serum cortisol levels and blood sugar values in these two groups either. Although numerous reports claim to have found a relationship between endogenous depression and diabetes mellitus, our data do not imply a direct relationship between serum cortisol and blood glucose levels of endogenously depressed patients.

Blood Glucose↗
PubMed1981

ABO blood groups in manic-depressive patients.

The authors compared the ABO blood type distribution pattern of 246 manic-depressive patients to that of 6000 controls. The blood type distribution of all patients did not differ from that of the controls. After subdivision of the patients into subgroups Bipolar I (n = 151) and Bipolar II (n = 95) significant differences were found for blood types O and A between the 2 subgroups, and between the Bipolar II patients and controls. The distribution of blood groups in Bipolar I subgroup did not differ from that of the controls. After division of the patients into 3 diagnostic subgroups (Bipolar-A, n = 30; Bipolar-B, n = 121; Bipolar-C, n = 95) significant differences were found in the distribution of blood groups O and A among the 3 subgroups, and Bipolar-A and Bipolar-C patients also differed from the controls. The results may provide additional support for the subclassification of bipolar major affective disorders into 3 subgroups.

ABO Blood-Group System↗
PubMed1980

Studies on the prolactin response induced by electroconvulsive therapy in schizophrenics.

Electroconvulsive therapy (ECT) and simulated ECT (SECT)-induced prolactin response has been studied in 14 schizophrenic males. Cortisol, growth hormone, and thyroid stimulating hormone (TSH) changes have been measured simultaneously. The prolactin rise was significantly higher after ECT than after SECT. Cortisol increase after ECT did not exceed significantly the elevation after SECT. Changes in growth hormone and TSH concentrations were inconsistent and non-significant. On the basis of the results it may be assumed that ECT-induced prolactin response is a consequence of specific transmitter changes in the CNS and not a result of stress reaction or generalized neuronal discharge. ECT-induced prolactin response was negligible in two cases. Both patients were chronically hospitalized schizophrenics resistant to therapy. Whether the prolactin response or its absence is of predictive value with respect to prognosis or effect of ECT remains to be seen.

Adult↗
PubMed1980

Effect of electroconvulsive treatment on brain monoamine content, pituitary-adrenal function and plasma prolactin.

The effect of electroconvulsive therapy used in psychiatry was investigated in rats. Electroconvulsion significantly increased the plasma prolactin, and decreased the hypothalamic dopamine content. The adrenal response (increase in plasma corticosterone) did not differ from the control groups. The results indicate that the prolactin response elicited by electroconvulsion is due to monoaminergic influence and not to the stress reaction.

Animals↗
PubMed1979

Endocrinological changes in patients with sexual dysfunction under long-term neuroleptic treatment.

Endocrine changes induced by dopaminergic inhibition may play a part in the development of sexual dysfunction (reduced libido/potency) in schizophrenic patients on long-term neuroleptic treatment. Prolactin, testosterone, LH and FSH serum level determinations by radioimmunoassays were performed in 24 schizophrenic males on long-acting fluphenazine decanoate treatment. Of these patients, sexual dysfunction was present in 17 cases, in 10 patients sexual activity remained unchanged. As compared to the 15 healthy controls (7.33 +/- 0.91 ng/ml), a significant increase of prolactin concentrations was found, i.e. 28.2 +/- 5.15 in the impotent groups, and 16.7 +/- 2.12 in the non-impotent group. The difference between the latter two mean values was, however, not significant. In the patients with normal sexual activity the increase of LH concentration was highly significant. It might be assumed that normal sexual behaviour despite neuroleptic treatment and hyperprolactinaemia is related to the high concentration of LH, though the mechanism of increased LH secretion has not been cleared as yet. The testosterone and FSH concentrations showed no differences in various groups.

Adult↗