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Biomedical subjects

M Armengol Carrasco

Publications and source records attributed to M Armengol Carrasco.

At least 19 recordsLinked to original sources
PubMed1995

[Morphometric study of somatostatin-producing "D" cells in duodenum and pancreas of the rat, following experimental antrectomy].

Given the inhibition of gastric secretion by the "D" cells producing somatostatin in antral mucosa, as well as evidence of disorders of the postprandial blood glucose after antrectomy, we may expect as a result of the antral resection a series of modifications in the content of the "D" cells in duodenum and pancreas. The study group was made up of 30 Sprague-Dawley albino rats, distributed in 3 groups as follows: Billroth I, Billroth II and laparotomy. The "D" cell study and the morphometric analysis after immunohistochemical avidin-biotin, was carried out with an automatic image analyzer and a morphometric calculation program. The results show that: the "D" cell population decreased significantly in the B-II group while the number of pancreatic islets and the average insular surface, did not show significantly differences in the tree groups, the relationship of the average insular surface with respect to the pancreas, decreased significantly in the two groups with antrectomy, expressing a hyperplasia of the exocrine pancreas and that the number of insular "D" cells decreased significantly in the B-II group and didn't change in the B-I group. These findings suggest that antrectomy, originates an increase of the exocrine pancreas and that antrectomy with gastrojejunal anastomosis excluding the duodenum, decreases the number of duodenal "D" cells and number of "D" cells of the pancreatic islets.

Animals↗
PubMed1992

Lower respiratory tract infections after abdominal operations: epidemiology and risk factors.

OBJECTIVE: To find out the incidence and aetiology of lower respiratory tract infections after abdominal operations and identify predisposing factors. DESIGN: Prospective open study. SETTING: Department of General Surgery, Hospital Germans Trias i Pujol, Barcelona, Spain. SUBJECTS: 2,083 patients having abdominal operations between March 1985 and June 1987 excluding splenectomies, and those requiring thoracoabdominal incisions. MAIN OUTCOME MEASURES: The presence of three or more of the following: temperature of 38 degrees C or more, cough with mucopurulent sputum, raised white cell count, or changes on the chest radiograph or bronchogram. RESULTS: 50 patients (2.4%) developed lower respiratory tract infections. Micro-organisms were isolated from 15 (30%), the most common being Haemophilus influenzae. The most important risk factors were American Society of Anesthesiologist's grade, duration of anaesthesia, age, and operations on the upper gastrointestinal tract. CONCLUSION: Further work is needed to investigate other possible predisposing factors and develop a predictive score.

Abdomen↗
PubMed1991

[The effect of duodenal exclusion on the cellular endocrine adaptation of the duodenum after performing an antrectomy. An experimental study in the rat].

We present an experimental study in rats with the aim to value the adaptative variations over the duodenal gastrin and somatostatin cell producing populations after antrectomy and gastrojejunostomy. 30 animals were distributed into two groups of 15 animals each. Group 1 rats underwent antrectomy and gastrojejunostomy, the animals of group 2 were considered as a controls. The results obtained show that after antrectomy and gastrojejunostomy an increase of gastrin producing cells is produced as well as decrease of somatostatin producing cells, both figures are statistically significant, concluding that the duodenum is able to supply the gastric antrum in gastrin production while the duodenal somatostatin cell producing population is negative influenced by the absence of alimentary stimuli and gastric secretions.

Adaptation, Physiological↗
PubMed1991

[Adaptation mechanisms to the short intestine. Influence of the biliopancreatic factor: experimental study].

Massive small bowel resection that results in short bowel syndrome brings about regulatory mechanisms in the remaining intestine aimed at preventing the ensuing malabsorption. The purpose of the present study was to determine the role of pancreatic and biliary secretions in intestinal adaptation after small bowel resection. To do so, both pancreatic and biliary fluids were prevented from reaching the lumen of most of the small bowel. Four groups of animals were prepared: I) control group; II) eighty percent small bowel resection; III) duodenoileal by-pass; and IV) duodenoileal by-pass plus small bowel resection. After a fifteen days recovery period, the following were recorded: animal weight; plasma protein, BUN, cholesterol, glucose, and Ca++; the length and diameter of the jejunum and ileum, the height of the mucosal layer, and microvilli density. Intestinal adaptation was excellent in animals after small bowel resection. All animals in group IV died due to severe malabsorption. Diversion of pancreatic and biliary juice in animals with duodenoileal by-pass did not prevent intestinal adaptation. We conclude that the effect of pancreatic and biliary juice on intestinal adaptation is additive to that of other putative hormonal mechanisms.

Adaptation, Physiological↗
PubMed1990

[Adaptive duodenal endocrine cell changes after antrectomy. Experimental study in the rat].

The known gastric endocrine relationship between "G" cells and "D" cells is altered after the loss of antral "G" cell population after antrectomy, leading to physiologic adaptative changes over the cell population producing gastrin and somatostatin in the duodenum, replacing thus the endocrine function of the resected gastric antrum. In this experimental study, Sprague-Dawley rats have been randomized in two groups, Control and Antrectomy with gastroduodenostomy, maintaining the alimentary stimulation of the duodenum. Endocrine "G" and "D" cell studies have been carried out by immunohistochemical staining with an Avidin-Biotin affinity technique. The statistical method used was the "t" test of Student. The results demonstrated a significant increase of the duodenal "G" cell population without changes of the duodenal "D" cell population after antrectomy and gastroduodenostomy. The endocrine cell ratio "G/D" in the duodenum increases due to the loss of antral gastrin release and the decrease of gastric acid output provoked by antrectomy.

Adaptation, Physiological↗
PubMed1989

[Degenerated papillomatosis of the bile duct].

Papillomatosis of the biliary ducts is exceptional. It is defined by the presence of multiple, benign, papillary type, epithelial tumors on the choledochus and hepatic ducts, and can also effect the gallbladder and intrahepatic bile ducts. It courses with a tendency to recurrence and secondary degeneration, and its prognosis is uncertain and sometimes grave. The treatment is surgical and depends on the extension of the lesions, often being only palliative. The techniques of choice are curettage and biliodigestive derivation. A case is presented of degenerated papillomatosis treated by cephalic duodenopancreatectomy and cholecystectomy.

Adenocarcinoma↗
PubMed1989

[Leiomyosarcoma of the small intestine].

Leiomyosarcoma of the small intestine is a rare neoplasm that has a difficult, and normally late, diagnosis. We present two cases operated in our service and discuss the different forms of clinical presentation, the surgical strategy and the controversial aspects of benignity and malignancy aspects. The survival is emphasized.

Aged↗
PubMed1979

[Segmental portal hypertension caused by volvulus of the spleen].

Volvulus of the spleen is a complication of a previous congenital anomaly consisting basically in the absence of supporting structures of the spleen. Clinically, it is an extremely rare complication. It may present as an acute abdomen. The search of the literature that we conducted does not show any such case being the cause of portal hypertension. This motivated this case report. The patient was treated surgically and this cured the patient.

Adult↗
PubMedDate not supplied

Utility of tumor marker CA 72.4 in patients with chronic renal failure.

The tumor marker CA 72.4 is composed of two monoclonal antibodies, B 72.3 and cc49, which detect the glycoprotein TAG 72 present in tumor cells. The levels of CA 72.4 may be modified depending on the route of excretion of the antigen TAG 72. The objective of this study was to evaluate the behavior of CA 72.4 in healthy subjects and to assess the influence of chronic renal failure (CRF) on the levels of this tumor marker. Random serum samples were collected in 181 individuals (148 healthy volunteers and 33 patients with CRF) and 214 determinations of CA 72.4 were performed. We also performed 66 determinations of plasma creatinine. In healthy subjects the cutoff value of CA 72.4 was established at 3 U/mL, with a sensitivity of 53% and a specificity of 85.8%. In the CRF patients we found no statistically significant differences when we compared the values of CA 72.4 predialysis and postdialysis (p = 0.197). However, a statistically significant difference was found in the plasma creatinine levels (p < 0.001). Chronic renal failure does not affect the result of CA 72.4 determinations; this tumor marker may therefore be useful in the monitoring of patients with cancer, independent of their renal function.

Adult↗