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Biomedical subjects

M Asaoka

Publications and source records attributed to M Asaoka.

At least 19 recordsLinked to original sources
PubMed2005

[Traumatic aortic regurgitation complicating chronic bronchitis; report of a case].

A 61-year-old man with diabetes mellitus and chronic bronchitis was brought to the hospital after falling from a roof accidentally. He received blunt trauma to the left chest wall including left rib fractures, pneumothorax, hemothorax and a fracture of left scapula. After endotracheal intubation and chest drainage, he was transferred to the intensive care unit. Sixteen days later, congestive heart failure appeared. Echocardiography showed a severe aortic valve regurgitation with a prolapse of non-coronary cusp. Eight months after the injury, his heart failure deteriorated. He underwent aortic valve replacement with a mechanical prosthesis. Upon examining the aortic valve, we noted 2 perforations in the non-coronary cusp of the aortic valve. Postoperative course was uneventful.

Accidents, Home↗
PubMed1998

[Combined rupture of trachea and esophagus following blunt trauma--a case report].

A 49-year-old man was involved in a motor vehicle crash and was admitted to a local hospital. The following day, he was transferred to our hospital because of worsening dyspnea. Initial examination revealed no subcutaneous emphysema, and chest computed tomography (CT) demonstrated no mediastinal air. A left thoracentesis tube was placed for pneumothorax, which reduced the patient's respiratory distress. He had a persistent, productive cough, which worsened when he drank water. A repeat chest CT on the fifth hospital day revealed a tracheo-esophageal fistula. Bronchoscopy and esophagoscopy confirmed the diagnosis. He underwent repair of the trachea and esophagus. The ruptured membraneous portion of the trachea was closed with interrupted sutures and covered with pedicled pericardial flap. The perforated anterior esophageal wall was sutured in layers and reinforced with a fifth intercostal muscle flap. A gastrostomy tuve was placed for feeding access. Within 6 weeks, the patient recovered completely.

Esophagus↗
PubMed1998

Maternal Nanos regulates zygotic gene expression in germline progenitors of Drosophila melanogaster.

Maternal Nanos (Nos) protein is required for germline development in Drosophila embryos. Here we show that Nos regulates zygotic gene expression in the germline progenitors, or pole cells. In order to probe the gene expression in pole cells, we screened ten enhancer-trap lines which showed beta-gal expression in pole cells. All of these enhancer-trap markers were fully activated in pole cells after their migration to the embryonic gonads. In the pole cells lacking Nos, the expression of nine out of ten enhancer-trap markers was affected. Among nine markers, five (Type-A) were prematurely expressed in the pole cells during the course of their migration. The expression of other four markers (Type-B) initiated correctly after pole-cell migration, but their expression was significantly reduced. Thus, we conclude that the maternal Nos plays a dual role in zygotic gene regulation in pole cells: to define the stages of expression for Type-A markers, and to enhance expression for Type-B markers. Contrary to our results, "Heller and Steinmann-Zwicky (1998)" have recently reported that no premature expression of Type-A markers occurs in the pole cells of embryos derived from nos mutant females. This discrepancy is due to the difference in the nos mutant alleles used for these analyses. We used the much stronger allele, nosBN.

Animals↗
PubMed1997

Video thoracoscopic resection of neurogenic tumor in a superior-posterior mediastinum: three case reports.

Neurogenic tumors of the thorax can originate in any neurogenic structure within the chest. Surgical resection is considered the primary treatment of such tumors and usually is performed through a thoracotomy. Recently, using a new approach, we applied the technique of video thoracoscopic surgery to resection a posterior mediastinal tumor. In this paper, we report three patients with superior-posterior mediastinal neurogenic tumors in which the approach to the tumor is technically difficult. Cases 1 and 2 were a 26-year-old man and a 50-year-old asymptomatic man, respectively, and case 3 was a 45-year-old asymptomatic woman. The sizes of the three tumors were 3.0 x 2.5 x 1.8 cm (case 1), 6.0 x 4.0 x 2.0 cm (case 2), and 3.0 x 2.0 x 2.0 cm (case 3). In one case (case 2), minithoracotomy was added to video thoracoscopic surgery for adhesion to the spinal artery and intraspinal extension. A standard thoracotomy was avoided in all three cases. All patients had uncomplicated postoperative courses. Video thoracoscopic resection of a neurogenic tumor in the superior-posterior mediastinum may be a safe and useful approach with improved cosmetic results.

Adult↗
PubMed1996

Essential role of the posterior morphogen nanos for germline development in Drosophila.

In many animal groups, factors required for germline formation are localized in germ plasm, a region of the egg cytoplasm. In Drosophila embryos, germ plasm is located in the posterior pole region and is inherited in pole cells, the germline progenitors. Transplantation experiments have demonstrated that germ plasm contains factors that can form germline, and germ plasm also directs abdomen formation. Genetic analysis has shown that a common mechanism directs the localization of the abdomen and germline-forming factors to the posterior pole. The critical factor for abdomen formation is the nanos (nos) protein (nanos). Here we show that nos is also essential for germline formation in Drosophila; pole cells lacking nanos activity fail to migrate into the gonads, and so do not become functional germ cells. In such pole cells, gene expression, which normally initiates within the gonad, begins prematurely during pole-cell migration. Premature activation of genes in germline precursors may mean that these cells fail to develop normally. A function for nos protein in Drosophila germline formation is compatible with observations of its association with germ plasm in other animals.

Animals↗
PubMed1996

[Quadricuspid aortic valve: report of a case associated with severe aortic regurgitation].

A case of quadricuspid aortic valve is reported. A 53-year-old man was admitted to our hospital for exertional dyspnea. He had a grade 3/6 to & fro murmur along the left sternal border. Aortogram showed grade 3 aortic regurgitation. The aortic valve consisted of two equal larger cusps and two equal smaller cusps, and a supernumerary cusp located between the right and noncoronary cusps. Aortic valve replacement was performed successfully and his post operative course was uneventful. On histological examination, the resected cusps showed fibrotic thickening and no sign of previous inflammatory disease. Quadricuspid aortic valve has been extremely rare. 27 Japanese cases of quadricuspid aortic valve which were corrected surgically are reviewed.

Aortic Valve↗
PubMed1996

[A case report of right-sided cardiac and pulmonary thromboembolism treated by emergent operation].

A forty-four-year-old man with a clinical diagnosis of diabetes melitus and severe obesity (height 170 cm, weight 108 kg) was admitted to the hospital on 12th January 1995 because of acute myocardial infarction, and on 21st January, he was referred to our hospital with sudden onset of shock, bradycardia, loss of consciousness in spite of having recovered well from myocardial infarction. The echocardiography and pulmonary arteriography revealed a pulmonary embolism and a tumor in the right atrium. Administration of tissue plasminogen activator (TPA) was not sufficiently effective. An emergency operation (pulmonary arteriotomy, right atriotomy, milking of bilateral lungs) with cardiopulmonary bypass revealed a massive consecutive thrombus, which occupied the right atrium, right ventricle and bilateral pulmonary artery. The postoperative course was uneventful.

Adult↗
PubMed1995

[A case report of primary pulmonary artery sarcoma].

A 49-year-old man was admitted because of dyspnea and generalized edema. CT scan pulmonary scintigram and cardiac catheter examination revealed pulmonary arterial obstruction due to a tumor associated with right heart failure. The tumor was extirpated as much as possible by a pulmonary arteriotomy under cardiopulmonary bypass. Postoperatively, right ventricular pressure decreased to about 40 mmHg while PO2 increased to the normal level. Histological examination of the tumor revealed rhabdomyosarcoma arising from the pulmonary artery. Chemotherapy consisting of a single course of CDDP and adriamycin was administered.

Humans↗
PubMed1995

[A case report of traumatic diaphragmatic hernia treated by thoracoscopic surgery].

A 56-year-old man who had been accidentally hit on the right side of the chest about 20 days previously was admitted because of intractable cough. Chest X-ray and CT scan revealed a right-sided diaphragmatic hernia and slight pneumothorax. No other hemorrhagic or perforative complications were detected. On the third hospital day, the patient underwent therapeutic thoracoscopy. Herniated transverse colon and liver were repaired through the abdominal cavity and the lacerated diaphragm was sutured through four thoracoports with video system assistance. The postoperative course was uneventful, and the patient was discharged 28 days later.

Endoscopy↗
PubMed1995

[Two cases of traumatic aneurysm of the aortic isthmus].

Two cases with blunt traumatic aneurysm of the aortic isthmus were treated recently. One was operated in early stage using heparin-bounded transient aorto-aorta bypass. The other underwent delayed operation with aorto-aorta bypass using centrifugal pump. Patch closures with Dacron fabric sealed by equine pericardium were performed in both of them with satisfactory results. We discussed the controversial problems, the timing of the operation and the method of adjunct circulation.

Adult↗
PubMed1994

[A successful surgical case of atrial septal defect with congenital factor XI deficiency].

We experienced a successful surgical case, who was a 16-year-old boy suffered from atrial septal defect with congenital factor XI deficiency. This disorder is an inherited disorder of blood coagulation characterized by a defect of the intrinsic pathway of thrombin formation and a mild to moderate bleeding tendency, but it can result in severe bleeding in surgical procedures. Open heart surgery in this disorders is rare. Preoperatively we prepared 4000 cc of fresh frozen plasma, but operated without using it. It would appear that the possibility of open heart surgery with congenital factor XI deficiency suggest in this case.

Adolescent↗
PubMed1994

[A case of pleural tumor with hypoglycemia].

A 72-year-old woman was admitted to the hospital because of hypoglycemia. Her glucose level on admission was 40 mg/dl. A giant intrathoracic mass was demonstrated on X-ray, Computerized tomographic scan of the cerebrum showed no abnormalities. Serum insulin and C-peptide levels were within normal limits. The mass (weight 2.3 kg) and the right lower lobe were excised by thoracotomy and the hypoglycemia ceased. Pathological examination revealed the mass to be a localized fibrous tumor of the pleura.

Aged↗
PubMed1993

[Six cases of traumatic diaphragmatic hernia].

In recent 3 years, six cases of diaphragmatic hernia caused by blunt trauma were treated surgically. Traumatic mechanics, appearance of rupture, associated injury, diagnostic procedure and surgical treatment are reviewed. All of them were survived with immediate surgical repair. Thoracoscopy is so useful to diagnose the right sided diaphragmatic hernia.

Adult↗
PubMed1993

[An emergent surgical case of the traumatic mitral regurgitation due to complete rupture of the papillary muscles].

We present a case of an emergency operation on acute MR and cardiac rupture due to a blunt thoracic trauma. This 27-year-old male suffered a severe blow to the chest when his motorcycle crashed to a tree. He was brought to this hospital by ambulance. On admission, the patient was in shock due to hypotension. Echocardiogram revealed cardiac tamponade and MR of grade 3/4. Pericardial drainage was performed immediately and his condition improved. Systolic pressure of the pulmonary artery was high at 70 mmHg which measured by Swan Ganz catheter. Isolated cardiac injury was diagnosed based on the results of various tests. A sign of acute pulmonary edema progressively deteriolated, therefore, emergent operation was performed on the same day. As cardiac fissure lesions were confirmed under cardiopulmonary bypass, we repaired the inferior side of the left ventricle and then closely examined the mitral valve. Both anterior and posterior papillary muscles were completely torn, so we immediately commenced with procedures to, replace a prosthetic valve. No complication were encountered, and the postoperative course was good. Complete ruptures of the papillary muscles due to trauma is rarely reported. We believe this case is exceptionally uncommon and worthy of reporting.

Accidents, Traffic↗
PubMed1991

[A treatment of intractable sternal osteomyelitis--significant use of pedicle muscular flaps].

In recent years, the greater omentum of pedicle muscular flap has been used to treat chest wall infection and Sternal Osteomyelitis following cardiac or respiratory surgery. In Japan, however, there has been an increasing number of cases in which neither the greater omentum Nor the rectus muscle can be used due to the comparatively young age of the patient. There are also many cases undergoing abdominal surgery for malignant tumor and bypass surgery of the coronary artery in which the internal thoracic artery (ITA) and gastroepiploic artery (GEA) are used. We studied three such cases; a case of coronary aortic bypass graft (CABG) where ITA from both the right and left sides were used following stomach resection; a case in which CABG and gallbladder resection were carried out simultaneously; and a case of sternal osteomyelitis is years following surgery for ventricular septal defect. All three cases had undergone reconstructive surgery using the pectoralis major muscle or a pedicle muscular flap from the latissimus dorsi muscle. It is estimated that cases of CABG using both the right and left sides of ITA and GEA, cases of the elderly as well as cases of children will continue to increase. Consequently, cases of sternal osteomyelitis in which neither the omentum nor rectus muscle can be used will also increase. Therefore, it is considered that treatment using pedicle muscular flaps from the breast or dorsal area may be very effective. Herein, we report on the choice of treatment and its results.

Aged↗
PubMed1990

[A case of tracheoesophageal fistula in Behçet's disease repaired with pericardial patch and gastric roll].

A 23-year-old man suffering from Behçet's disease developed a tracheoesophageal fistula. Subtotal esophagus was stripped and replaced with a gastric tube along greater curvature. The defect of membranous portion of the trachea (2 X 1 cm) was closed with a pedicled pericardial patch and covered with omentum. Transient postoperative recurrent nerve palsy was recovered in about 2 months. He is going well without any significant complaints. He received steroid hormone administration and platelets transfusion because of complicated ITP (Idiopathic Thrombocytopenic Purpura).

Adult↗
PubMed1989

[Experience of coronary artery bypass grafting using internal mammary artery: operative results with 102 cases during initial three years].

From April 1985 to March 1988, internal mammary-to-coronary artery anastomosis was performed in 102 patients. One postoperative death and one hospital death occurred. Early postoperative arteriography showed good patency rate. The early patency rate was 99% in 53 vein grafts, 95 in 100 internal mammary artery grafts and 75% in 4 gastroepiploic artery grafts. The main obstacles to coronary revascularization with internal mammary artery have been the delicate nature of the arterial grafts and difficult technique in anastomosis. We used the modified "No-Touch Technique" reported by Cheanvechai. Our technique is available to avoid trauma during coronary revascularization with arterial graft and to anastomose correctly.

Adult↗