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Biomedical subjects

M Atienza Fernández

Publications and source records attributed to M Atienza Fernández.

7 recordsLinked to original sources
PubMed1993

Decision analysis applied to the selection of angiotensin-converting enzyme inhibitors.

Decision analysis is applied to the group of angiotensin-converting enzyme inhibitors, in order to select those which should be included in the hospital formulary and to establish a research method which allows the reproduction of the process with new, related drugs. Captopril, enalapril and lisinopril were the alternatives considered. Evaluation criteria were efficacy, clinical experience, safety, dosage interval, hepatic bioactivation, interactions, dosage forms and cost. A relative weight was assigned through a survey among the hospital's staff. Each alternative was evaluated in relation to all criteria. Sensitivity analysis was applied to validate the method. Enalapril obtained the highest score, followed by lisinopril and captopril. The sensitivity analysis confirms this result. Enalapril is selected for the hospital formulary due to its higher score, although the differences between the three are very small.

Angiotensin-Converting Enzyme Inhibitors↗
PubMedDate not supplied

[Protein C concentrate in the treatment of severe sepsis in the pediatric setting].

Patients with severe sepsis develop acquired protein C deficiency, and the extent of such deficiency and negative clinical outcomes correlate. Replacing this protein may help prevent such a condition. Two protein C types are commercially available - concentrated and activated proteins. None is registered for the treatment of severe sepsis in the pediatric setting. Experience with protein C in this group of conditions is limited. Appropriate clinical trials are required to establish effectiveness and safety, and to elucidate the role of either protein C type in the management of this condition in the pediatric setting. This paper discusses experience with the use of protein C concentrate as an adjuvant treatment in addition to conventional therapy in three children with severe sepsis at a Pediatric Intensive Care Unit. In all 3 cases of our study, high levels of protein C correlated to coagulation parameter normalization and reduced dimer D levels. Two out of three had a favorable outcome following treatment, whereas the third patient died as a result of septic shock and multiple organ dysfunction.

Child, Preschool↗
PubMedDate not supplied

[Interstitial cystitis: drug therapy].

The present job reviews the etiology, clinical presentation, diagnostic and treatment of interstitial cystitis. An exhaustive revision is made of all the possibilities of pharmacological treatment with a special mention to the two major drugs: dimethylsulfoxide and pentosampolysulphate. A critical judgement of existing clinical trials is made. The conclusion indicates the need of more controlled experimental work in the future to allow a more objective determination of the most appropriate and effective therapy for these patients.

Cystitis↗
PubMedDate not supplied

[The quality control of a photoprotector bag against ultraviolet light].

The action of light on parenteral nutritional solutions may affect the stability of many of their ingredients. The aim of this study is to perform quality controls on a commercial photoprotective bag by quantifying the degradation of riboflavin in isotonic saline solution during forty-eight hours. Thirty solutions were prepared using 5 mg of riboflavin in 500 ml of saline solution. These were divided into three batches; one not protected from the light, one in a black bag and the third in a commercial bag. Samples were taken at 0 and 48 hours, and were analyzed by spectrophotometry. Solutions were prepared using 1.75 mg of riboflavin in 500 ml of saline solution. The same method was followed, and the samples were analyzed by fluorometry. The results were analyzed using the Student t test. The black bag was seen to be superior to the other two as a protector against ultraviolet light. There were no significant differences between the commercial bag and the non-protective bag.

Evaluation Studies as Topic↗
PubMedDate not supplied

[Microbial growth in parenteral nutrition. II. Effects of osmolality].

Study on the behaviour of five microorganisms in different formulations of Parenteral Nutrition (PN) different from each other with regard to osmolarity. The organisms investigated were Staphylococcus aureus (ATCC (12600), Bacillus subtilis (ATCC 6051), Pseudomonas aeruginosa (ATCC 9027), Enterobacter cloacae (ATCC 13047) y Candida albicans (LSH 3156 D). It was observed no direct relation between microbial growth and osmolarity in PN. C. albicans showed the best growth in all the formulations tested, followed by E. Cloacae. The number of the other microorganisms is reduced, and in general, except B. subtilis grow or are reduced in a lesser extension when the glucose solutions added are at 30 or 40%.

Bacteria↗
PubMedDate not supplied

[A microbial growth study in parenteral nutrition].

Study on the behaviour of five microorganisms in different formulations of parenteral nutrition (PN) different from each other with regard to the presence or absence of lipids and the addition of vitamins or oligoelements. The bacteria investigated were Staphylococcus aureus (ATCC 12600), Bacillus subtilis (ATCC 6051), Pseudomonas aeruginosa (ATCC 9027) and Enterobacter cloacae (ATCC 13047), as well as Candida albicans (LSH 3156 D). It was observed that C. albicans grew well in all types of PN tested, S. aureus and E. cloacae showed growth in the formulations containing lipids, whereas in those lacking lipids, the number of microorganisms remained practically uniform. P. aeruginosa remained essentially constant throughout the study and in all mixtures and B. subtilis was reduced with regard to the number of feasible organisms, due to the formation of spores. Finally, the addition of vitamins or oligoelements did not appear to determine a particular model of evolution in any of the species studied.

Bacteria↗