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Biomedical subjects

M Aufdermaur

Publications and source records attributed to M Aufdermaur.

13 recordsLinked to original sources
PubMed1989

Pathogenesis of square bodies in ankylosing spondylitis.

The pathogenesis of squaring of the vertebral bodies is analysed in a 25 year old patient with ankylosing spondylitis. The squaring derives from a straightening of the anterior contour. The disease was diagnosed five years before the patient's death. The remodelling of bone that explains squaring of the vertebral bodies is described for the first time. Histologically, an acute and chronic spondylitis with destruction and simultaneous rebuilding of the cortex and the spongiosa of the vertebral bodies has been found. The development of square vertebral bodies is shown to be based on a combination of a destructive osteitis and repair.

Adult↗
PubMed1979

[Chondrocalcinosis (pseudogout) of the meniscus].

Among 1060 histologically examined meniscus cartilages from patients aged 11--74 years 20 (2%) had chondrocalcinosis. Age at onset of symptoms was 28--67 years, duration of symptoms until surgical removal of the meniscus six weeks to 20 years. All patients had pain, 12 had pain-independent limitations of knee movement. Effusions of the knee were present in ten. Independent of the radiological findings, in the majority of patients the symptoms were markedly improved or completely absent one-two years after meniscus removal. All meniscus specimens revealed severe changes both macroscopically and histologically. The clinical diagnosis confirmed by demonstrating calcium pyrophosphate crystals in haemalauneosin stained sections, examined by polarisation microscopy. The X-ray films demonstrated arthrosis in at least 50% of cases. There appeared to be a close mutual relationship between chondrocalcinosis and arthrosis of the knee-joint.

Adolescent↗
PubMed1979

Degeneration of the intervertebral disks and spondylosis in aging sand rats.

Aging sand rats (Psammomys obesus) kept on a standard laboratory diet supplemented by salt bush--their natural source of food--were examined for changes of the vertebral column. From about 6 months of age on, degeneration of the intervertebral disks was noted. The changes increased in severity with increasing age, and from 1 1/2 years of age on, massive multiple disk herniations were seen. Associated with these lesions were spondylosis of "intervertebral" as well as hyperostotic type, and osteoarthrosis of the apophyseal joint. The sand rat seems to be an excellent model for the study of the pathogenesis of spinal diseases associated with the aging process.

Aging↗
PubMed1977

[Rhemuatismus nodosus. Relationship between joint findings and rheumaserology in chronic polyarthritis].

The clinical course and radiologic and serologic findings are reported in 37 subjects who, during the years 1954 to 1974, had rheumatoid nodules removed and examined histologically. The observations were classified into four groups according to a system similar to that of Steinbrocker. The histological findings were the same in all four groups. In 4 subjects the diagnosis of rheumatoid arthritis was established by the biopsy. In 5 additional patients the histologic examination confirmed the clinical diagnosis. Radiologically the joints of 5 adults were unremarkable while those of 14 subjects had developed slight or moderate changes, and in 18 patients advanced destruction or deformities or ankylosis were present. In instances of marked joint destruction the course of the disease may, spontaneously or after appropriate treatment, become bland. 90% of our patients were seropositive and 10% seronegative. 9 subjects had temporarily low RF serum titers. Serologic data are of value for the differential diagnosis of joint diseases. They are not, however decisive.

Adolescent↗
PubMed1977

[Pathological bone structure (author's transl)].

The pathological and anatomical basis of various radiographic changes in a number of diseases of the skeleton is discussed. The conditions include abnormalities of bone formation and bone removal, including osteoporosis, fibrous dysplasia, osteomyelosclerosis, osteitis deformans, posttraumatic changes and ossifying periostitis. The form and structure of the pathological and anatomical substrate determine the radiological appearances and are essential for arriving at a diagnosis.

Adult↗
PubMed1975

[Whiplash injury (author's transl)].

The whiplash injury is the result of a collision from behind in the motorized street traffic. The impact in the rear of the vehicle causes a sudden thrust to of the head and cervical spine in dorsal direction. The result is a shear effect of the cervical spine. Pathologically, this is characterized by hematoma of the capsules of the joints of the vertebral arches and contents of intervertebral foramina. Tears of discs and vertebral fractures are usually absent. The prognosis is good.

Cervical Vertebrae↗
PubMed1975

[Early histological findings of carcinoma of the breast (author's transl)].

Histologically the early histological findings of the carcinoma of the breast enclose lobular and intraductal carcinoma in situ, and atypical epithelial proliferation. Without mastectomy a considerable percentage of these cases will develop invasive carcinoma. In order to detect these early forms of carcinoma mammography should be carried out. Following this procedure a more precisely located histological examination can be performed. The treatment consists of simple mastectomy.

Breast Neoplasms↗