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M Avignon

Publications and source records attributed to M Avignon.

At least 19 recordsLinked to original sources
PubMed1995

Occupational exposures estimated by means of job exposure matrices in relation to lung function in the PAARC survey.

OBJECTIVES: The aim of this analysis of the French Cooperative PAARC (Pollution Atmosphérique et Affections Respiratoires Chroniques) survey, was to test whether occupational exposures to dusts, gases, or chemical fumes or to specific hazards, estimated by job exposure matrices, were related to a decrease in forced expiratory volume in one second (FEV1). METHODS: The most recent occupation was recorded in adults, aged 25-59, from non-manual worker households. Analysis was restricted to 10,046 subjects whose occupation was encountered at least 10 times in the study and who performed good FEV1 tracings. From occupational title, exposures to dusts, gases, and chemical fumes, and to specific hazards were classified in three categories (no, low, and high) with a British, a French, and an Italian job exposure matrix. Specific hazards were analysed for the British and French job exposure matrices for the same 42 specific dusts, gases, and chemical fumes. To limit spurious associations, a selection of seven hazard groups and 12 specific hazards was set before the start of the analysis. Based on the consistency of the relations according to sex and the British and French job exposure matrices, associations of age, height, city, and smoking adjusted FEV1 score with occupational exposures were classified as very likely, possible, or unlikely. RESULTS: For the three job exposure matrices and both sexes clear exposure-response relations between the level of exposure to dusts, gases, and chemical fumes, and a decrease in FEV1 were found. Associations with FEV1 were classified as very likely for known hazards such as organic dusts and textile dusts, and not previously recognised hazards such as polycyclic aromatic hydrocarbons (PAHs) and detergents, and as possible for solvents, waxes and polishes, and diesel fumes. Associations found for PAHs and solvents were confirmed by the Italian job exposure matrix. Associations remained significant in women, but not in men, after adjustment for educational level. CONCLUSIONS: Hypotheses have been generated for exposure to detergents, PAHs, and solvents, but they need to be interpreted with caution before replication. Significant associations found for known risk factors with a decrease in FEV1 are arguments for the validity of the matrices. Despite the expected limitations of job exposure matrices, these results encourage further work to improve exposure assessment by job exposure matrices.

Adult↗
PubMed1985

[Antibiotic-resistant coliforms in a purification station on a pig-breeding farm].

The survival of antibiotic-resistant enteric bacteria in the effluent treatment plant of a pig farm was studied by quantitative determinations of resistant and sensitive populations at different sites of the effluent purification process. The effluent treatment system, combining storage and aeration tanks, reduced the concentration of enteric organisms in the output of the plant to about one-tenth of the concentration found in the incoming untreated slurry. This reduction occurred mainly at the level of the aerated tank and was observed for the total population of enteric organisms as well as for the various populations resistant to ampicillin, chloramphenicol, kanamycin, streptomycin and tetracycline respectively. Moreover, no particular sequence of resistances seems to have been selected during treatment. Storage and aeration of pig slurry before disposal reduces the risk of dissemination of antibiotic-resistant bacteria of animal origin in the environment, as compared to the frequent direct spreading of untreated effluents.

Ampicillin↗