Biomedical subjects

M B Danielov

Publications and source records attributed to M B Danielov.

4 recordsLinked to original sources

PubMed1977

[Undifferentiated X-linked oligophrenias].

In the course of investigation of 262 families with non-differentiated forms of oligophrenias it is established that in 48 families (18.3%) mental deficiency in sibs is caused by pathological mutations in the X-chromosome. Besides, it is not excluded that in certain inbred families oligophrenia in female persons is also, due to mutations linked with X-chromosome. This is supported by the dependence established between the frequency of the cases of oligophrenia among female persons and the inbreeding coefficient for the X-linked loci. The possibility of manifestation of the recessive genes of oligophrenia linked with X-chromosomes in heterozygous state is discussed.

Female↗

PubMed1976

[Genetic analysis of microcephaly].

A clinical genetic examination of 22 cases of hereditary microcephaly in 11 families was carried out. Parent consanguinity (first and second cousins) was ascertained in 7 families. Genetic analysis of the experimental material performed by Weinberg's method showed significantly recessive course of the genuine microcephaly inheritance. High frequency of low degree mental retardation (30%) among probable recessive genes carriers of microcephaly (of the parents and their siblings) was ascertained and that confirmed the possibility of gene heterozygous state manifestation. The gene frequency fluctuated from 0,0042 to 0,024. About 3500 people might show low forms of mental retardation in connection with probable non-penetration (about 30%) of the microcephaly genes being in heterozygols state.

Consanguinity↗

PubMed1975

[Inbreeding in the Samarkand region].

Data on the frequency of inbreeding in some isolated populations of Samarkand region are given. Statistically significant differences were established in the frequency of inbreeding in separate groups and in the general population of the region. Inbreeding marriages were more observed between paralel cousins, occasionally they were made between secon cousins. Strict time dependence of inbreeding frequency was not found, but it was noticed that the level of inbreeding was reduced since 1930 to 1949.

Consanguinity↗

PubMed1975

[Inbreeding in the Samarkand region].

Data on the frequency of inbreeding in some isolated populations of Samarkand region are given. Statistically significant differences were established in the frequency of inbreeding in separate groups and in the general population of the region. Inbreeding marriages were more often observed between paralel cousins, occasionally they were made between second cousins. Strict time dependence of inbreeding frequency was not found, but it was noticed that the level of inbreeding was reduced since 1930 to 1949.

Consanguinity↗