M B Davies | PubMed Health

PubMed1989

Recommended minimum data to be collected in research studies on Alzheimer's disease. The MRC (UK) Alzheimer's Disease Workshop Steering Committee.

In order to be able to compare the results of research work carried out in different centres on Alzheimer's disease and dementia, it is necessary for there to be standardised assessment methods. The Medical Research Council organised a workshop in order to see whether workers in Britain in the field of dementia research could agree on such standardised assessment methods. The workshop agreed guidelines for the minimum data which should be collected, in clinical and pathological studies, on patients with presumed Alzheimer's disease and dementia. These recommendations are compared with other approaches based on research diagnostic criteria.

Aged↗

PubMed1988

Eyeblink-related potentials.

When the EEG is averaged time-locked to blinks, and the part of the potential that is proportional to the EOG is subtracted, a signal (the 'residuum') remains which resembles an event-related potential (ERP). The blink time-locked average (BTA) was investigated to determine whether the components of the residuum are due to a cerebral blink-related potential or to artifacts of the EOG which subtraction failed to remove. The BTA was obtained from 12 subjects using voluntary blinking in the light and in complete darkness. Differences between the potentials in light and dark indicate that a major component of the residuum is a visual evoked response elicited by the off-on light stimulus associated with blink eye closure. The results are discussed in relation to attempts to correct blink artifacts in ERP experiments and, by drawing parallels between the residuum and the lambda potential associated with saccades, similar inferences are made for the correction of eye movement artifacts.

Adult↗