Biomedical subjects

M B Hogan

Publications and source records attributed to M B Hogan.

21 records · Page 2Linked to original sources

PubMed1994

A naturally occurring model of immunoglobulin E antibody-mediated hypersensitivity in laboratory animals.

A naturally occurring model of immunoglobulin E (IgE) antibody-mediated hypersensitivity in canine and rhesus monkey species to environmental allergens is described. Cutaneous responses to a dust mite mix (Dermatophagoides farinae/pteronyssinus) and to four storage mite extracts (Aleuroglyphus ovatus, Blomia tropicalis, Chortoglyphus sp., Lepidoglyphus destructor) occurred in the canine species. Rhesus monkeys had IgE antibody-mediated hypersensitivity to dust mite on cutaneous challenge, but to a lesser degree than the canine species. Biologic relevance was verified by eliciting positive airway challenges in both species. The IgE antibody-mediated basis of these responses was confirmed by passive transfer technique. Demonstration of dust mite allergy provides a naturally occurring model of IgE antibody-mediated hypersensitivity in the canine and rhesus monkey species. Storage mite IgE antibody-mediated hypersensitivity exists in the canine species.

Aerosols↗

PubMedDate not supplied

Heterogeneity of histamine releasing factors and IgE.

Advances in our understanding of cytokines and their effects seem to occur almost on a daily basis. The first description of a cytokine causing histamine release was in 1979. Since that time several cellular products have been described which cause histamine release. The following is a general review of the literature concerning histamine releasing factors and their IgE interactions.

Antibodies, Heterophile↗

PubMedDate not supplied

Laryngeal papilloma presenting as steroid-dependent asthma in a 3-year-old child without recurrent stridor.

Upper airway obstruction is well described as a cause of apparent asthma. However, it can be very difficult to diagnose in young children. This 3-year-old male presented with a 1-year history of severe recurrent wheezing with six emergency room visits in the previous 5 months. Cromolyn, inhaled corticosteroids, and frequent predinisolone bursts had not controlled the wheezing. There was no history of barky cough, croup, or stridor. His physical examination was notable for marked nasal obstruction. At initial presentation, his lungs were normal with no wheezing or stridor. Soft tissue neck X-ray films suggested the presence of a subglottic mass. A large solitary papilloma was found on bronchoscopy. After surgical removal, there was no further wheezing noted by either the parents or his physicians. Laryngeal papillomatosis may mimic asthma in the absence of symptoms of hoarseness, croup, or stridor. It should be particularly considered in 2 to 4-year-old children with recurrent wheezing that is poorly responsive to aggressive therapy including oral corticosteroids.

Airway Obstruction↗