Documentation of suprachoroidal hemorrhage during B-scan ultrasonography. Case report.
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Adult↗
Biomedical subjects
M B Kaback
Publications and source records attributed to M B Kaback.
Comparative intraocular pressure effects of adsorbocarpine and isoptocarpine.
Nine symmetrical ocular hypertensives used Adsorbocarpine in one eye and Isoptocarpine in the other. Each medication was given twice daily for one week, then Isoptocarpine was used 4 time daily. The 2 drugs were equally effective as twice daily medications while Isoptocarpine 4 times daily was significantly more effective than either given twice daily. The pH of the Adsorbocarpine may not have been optimal although commercially available solutions were used. The results indicated that pilocarpine in either vehicle can lower intraocular pressure when given less than 4 times daily; however, conclusive studies are needed before this can be recommended as a widespread clinical practice.
Clinical Trials as Topic↗
Long-term epinephrine therapy of ocular hypertension.
Nineteen patients with symmetrical ocular hypertension and symmetrical cupping of the optic nerves were made asymmetric with respect to intraocular pressure for one to five years by unilateral topical treatment with epinephrine hydrochloride. Development of glaucomatous visual field defects was observed in 32% of the untreated eyes and in none of the treated eyes (P less than .05). Progressive cupping of the optic nerve was noted in 53% of the untreated eyes and in 11% of the treated eyes (P less than .025). Evidence of glaucomatous damage was observed more frequently in subjects maintained on this regimen for longer periods and in subjects with initial horizontal cup/disc ratios greater than 0.4 (P less than .05). None of the eyes, either treated or untreated, with mean intraocular pressures less than 24 mm Hg developed glaucomatous damage during the period of this study.
Administration, Topical↗
Relative afferent pupillary defect in glaucoma.
Seven patients with asymmetrical open-angle glaucoma had relative afferent pupillary defects. This defect may have occurred during any stage of glaucoma, but the presence of this sign may be indicative of the earliest onset of optic nerve damage in patients with ocular hypertension. Although the presence of an afferent pupillary defect should suggest the consideration of a neurologic lesion, glaucomatous damage may be the sole explanation for this phenomenon.
Adult↗
The effects of dipivalyl epinephrine on the eye.
We treated one eye each of ten patients with ocular hypertension with dipivalyl epinephrine (DPE), a congener of epinephrine. Pupil size and intraocular pressure were measured before and at intervals up to 240 minutes after instillation of a single drop of DPE in concentrations from 0.005 to 0.5%. Concentrations of 0.025% DPE and greater significantly reduced IOP, and mydriasis was induced by concentrations of 0.1% DPE or greater. Comcentrations of 0.1% DPE, instilled twice daily for one month, significantly reduced intraocular pressure during diurnal testing on days 2 and 31. No toxic side effects were noted. The DPE produced dose-related increases of cyclic adenosine monophosphate in the aqueous humor of rabbits.
Animals↗