Biomedical subjects
Publications and source records attributed to M B Kashlan.
A case report of diffuse pigmented villonodular tenosynovitis involving the entire ulnar bursa and a review of the literature are presented. There have been few reports of the diffuse form of pigmented villonodular tenosynovitis involving the hand as compared to the localized nodular form, which is a common tumor of the hand. Complete tenosynovectomy of the involved areas is recommended.
Useful morphologic criteria for frozen section diagnosis of pancreatic and periampullary carcinoma were established by prospective review of 64 frozen sections in this region, with permanent section correlation and patient follow-up. These were divided into three major and five minor criteria based on frequency of occurrence and reproducibility. Major criteria were: 1) nuclear size variation of 4:1 or greater between ductal epithelial cells, 2) incomplete ductal lumens, and 3) disorganized duct distribution. Minor criteria, less frequently and reproducibly observed but valuable diagnostic aids, included: 1) huge, irregular epithelial nucleoli; 2) necrotic glandular debris; 3) glandular mitoses; 4) glands unaccompanied by connective tissue stroma within smooth muscle bundles (periampullary biopsies); and 5) perineural invasion. Combined application of both major and minor criteria is especially helpful in cases complicated by chronic pancreatitis.
A previously well 9-year-old boy developed acute autonomic and sensory neuropathy. Recovery was incomplete over a thirteen-month period. Spinal fluid protein was increased during the acute phase. Sensory nerve potentials were absent in the presence of normal motor and mixed nerve conduction velocities. Sural nerve biopsy revealed marked axonal degeneration of myelinated as well as unmyelinated fibers. This case represents a widespread acute ganglionopathy of unknown cause.
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