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Biomedical subjects

M B Møller

Publications and source records attributed to M B Møller.

43 records · Page 3Linked to original sources
PubMed1982

Intracranially recorded auditory nerve response in man. New interpretations of BSER.

Compound action potentials were recorded from the intracranial part of the human auditory nerve when it was exposed during surgery with the use of a posterior fossa approach. Monopolar recordings of the response to tone bursts were dominated by a negative deflection that reached a peak 3 to 3.5 ms after the onset of a 5-ms 2-kHz tone burst. This negative peak matched the latency of the second vertex-negative peak of the scalp-recorded brainstem evoked responses (BSERs). Bipolar recordings from the intracranial part of the auditory nerve showed the biphasic waveshape that is typical for a nerve trunk. The results indicate that the neural generators not only of the peak in the BSER are likely to be located in the auditory nerve. Furthermore, the results indicate that it is the third wave that originates in the cochlear nucleus, not the second wave as was previously assumed.

Brain Stem↗
PubMed1981

Intracranially recorded responses from the human auditory nerve: new insights into the origin of brain stem evoked potentials (BSEPs).

Auditory evoked potentials were recorded intracranially from the 8th nerve during neurosurgical procedures. The potentials had a large negative peak that occurred 3.0--3.7 msec after the onset of the stimulus (2 000 Hz tone bursts). When these potentials were compared with the scalp recorded brain stem evoked potentials (BSEPs) the intracranial response was found to match the latencies of the P2N3 complex of the BSEP. The results are interpreted as showing that the neural generator of the second peak of the BSEP is the intracranial portion of the auditory nerve and not, as was earlier assumed, the cochlear nucleus.

Acoustic Stimulation↗
PubMed1981

Hearing in 70 and 75 year old people: results from a cross sectional and longitudinal population study.

Audiometric data are presented from a cross sectional and longitudinal population study of 70 and 75 year old people in Gothenburg, Sweden. The population studied included 1148 randomly selected 70 year old men and women. A subsample of 376 was tested with pure tone and speech audiometry. Five years later 261 of those were tested again with the same methods. The mean pure tone thresholds were only 8 to 10 dB. higher than data chosen as representative for presbycusis in selected populations. Between the ages of 70 and 75 there was no detectable change in the pure tone thresholds for men. The hearing threshold in women had deteriorated throughout the entire frequency range and most were at 4 and 8 kHz. Speech discrimination scores were unexpectedly high. Seventy-five per cent of the women and 50 per cent of the men had discrimination scores equal to or better than 92 per cent at the age of 70. At the age of 75 about 65 per cent of the women and 35 per cent of the men had the same excellent speech discrimination

Aged↗
PubMedDate not supplied

Association of testicular non-Hodgkin's lymphomas with elevated serum levels of human chorionic gonadotropin-like material.

Serum beta-human chorionic gonadotropin (s-beta-hCG) is a widely used tumor marker in patients with testicular neoplasia. When elevated in patients with an enlarged testis it is considered as a strong indication of a germ cell tumor. Elevation of S-hCG-like material (S-hCG-1) has been reported in nontesticular non-germ cell tumors including non-Hodgkin's lymphomas (NHL) as well. It has never been investigated whether testicular NHL is also associated with elevated S-hCG-1. In the present study the relationship of testicular NHL with increased S-hCG-1 was investigated. In the Danish population-based NHL registry, LYFO registry, 12 cases with testicular involvement of the lymphoma at the time of diagnosis and that had S-hCG-1 measured prior to treatment were identified, and cases with elevated S-hCG-1 were analyzed clinicopathologically. Of these, 2 patients had elevated levels. Both cases were high-grade, diffuse B-cell NHL in elderly patients. The patients were hemiorchiectomized and after surgery levels of S-hCG-1 declined to normal. The study indicates that S-hCG-1 elevation is quite frequently associated with testicular NHL. The prognostic significance of this elevation remains to be investigated, as does the usefulness of S-hCG-1 as tumor marker for early detection of recurrences and for monitoring the therapy of patients with S-hCG-1 positive NHL.

Aged↗
PubMedDate not supplied

Neural generators of brainstem evoked potentials. Results from human intracranial recordings.

Recordings were made from the auditory nerve near its entrance into the brainstem during neurosurgical operations for cranial nerve disorders. The recorded compound action potentials in response to 2000 Hz tonebursts at 90 dB were characterized by a negative peak with a latency of 3.0 to 3.7 ms. When these compound action potentials were compared with the brainstem evoked potentials (BSEP) recorded from the scalp during the operation or before the operation, it was found that the latency of the main peak of the compound action potential matched the latency of the vertex negative wave located between waves II and III (P2) and the potentials recorded from the nerve were found to match the N2P2N3 complex of the scalp-recorded BSEP. The results indicate that the auditory nerve is the neural generator of the two first peaks in the human BSEP, in contrast to the results of experiments in animals which show that the second peak originates in the cochlear nucleus.

Animals↗
PubMedDate not supplied

Brainstem auditory evoked potentials in patients with cerebellopontine angle tumors.

Changes in the brainstem auditory evoked potentials of 27 patients with cerebellopontine angle tumors were analyzed. It was found that the most characteristic change was an increase in the latency of wave III on the affected side. In patients with tumors large enough to cause displacement of the brainstem, there was in addition an increase in the latency of wave III on the unaffected side. These results are consistent with recent observations regarding the neural generators of the brain stem auditory evoked potentials in humans.

Adolescent↗