Structural similarity between transforming growth factor-beta 2 and nerve growth factor.
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Amino Acid Sequence↗
Biomedical subjects
M B Swindells
Publications and source records attributed to M B Swindells.
Structure prediction and modelling.
Cracking the second fundamental code of molecular biology (how the tertiary structure of a protein is determined by its amino acid sequence) remains an elusive goal. However, the impetus to establish credible approximations, if not a definitive solution to this relationship, has never been greater. In the past year significant progress has been made through a series of novel approaches. This review describes the most important developments and outlines how they can be usefully employed by those whose specialization lies outside the field.
Models, Molecular↗
Protein structure. Prediction of progress at last.
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Amino Acid Sequence↗
Structure prediction and modelling.
Protein structure prediction from sequence remains a major goal in molecular biology. The methods described in this review concentrate on deriving structural information through the detection of similarities between a test sequence and a database of known structures. Such methods are often referred to as knowledge-based strategies reflecting the use of a structural database in the analyses. The past year has seen considerable advances in both the development of automated procedures and their application to protein sequences of outstanding biological interest.
Algorithms↗