Biomedical subjects

M B Wingate

Publications and source records attributed to M B Wingate.

At least 19 recordsLinked to original sources

PubMed1986

Vulvar dystrophies in geriatric patients.

The term vulvar dystrophies has received international acceptance and replaces the confusing terminology formerly used to describe vulvar epithelial disorders. The classification is based on histopathologic features and has provided a more rational foundation for the use of specific therapies. The risk of malignant change is small and depends on the presence or absence of atypical cells. Biopsies are mandatory for diagnosis and therapy. Vulvar dystrophies without atypia are benign lesions whose primary treatment is medical.

Aged↗

PubMed1984

Reactivity of monoclonal antibody F36/22 with human ovarian adenocarcinomas.

Monoclonal antibody F36/22 recognizes high-molecular-weight glycoprotein components associated with neoplastic development of the ovary. Indirect immunoperoxidase staining techniques were performed on a panel of nonmalignant ovarian tissues, primary ovarian tumors, exfoliated ascitic tumor cells, and metastatic lesions. Normal ovarian tissue components (n = 20) failed to exhibit detectable levels of antigen, whereas benign ovarian tissues show a low incidence of immunostaining (three of 26) restricted to some ductal elements. One hundred % (19 of 19) of the immunopositive primary malignant tumors were histologically classified as adenocarcinomas. Each of the predominant adenocarcinoma histotypes consistently showed expression of the antigen with 30 to 100% of the tumor cells scored as immunopositive. Ascitic tumor cells obtained from all of the ovarian adenocarcinoma patients examined (47 of 47) displayed immunopositive reactions, whereas normal mesothelial cells in these specimens exhibited undetectable staining. In addition, ovarian adenocarcinoma metastases (12 of 12) exhibited very intense immunoreaction products. No detectable antigen was expressed by nonadenocarcinoma ovarian tumor cells.

Adenocarcinoma↗

PubMed1984

Postmenopausal osteoporosis: concerns and costs in clinical management.

There are a number of social, political and medical concerns for the clinician dealing with female patients who are postmenopausal and at risk for the development of osteoporosis which may lead to chronic disability and possibly death. A brief overview of the role of current therapies is given together with their potential for adverse effects. Further research into etiology, diagnosis and optimum management is obviously necessary.

Aged↗

PubMed1979

Congenital atresia of the cervix.

A case of rare müllerian anomaly, congenital atresia of the cervix in a functional bicornuate uterus, is presented together with a review of the literature in English. The patient in this case took an active role in the decision regarding the nature of the surgical treatment she was to undergo. It is suggested that total hystrectomy with preservation of the ovaries is the treatment of choice.

Adolescent↗

PubMed1979

Continuing medical education. Format preference in northwestern New York.

Explore the source record for details and available documents.

Attitude↗

PubMed1978

Obstetric factors in cerebral palsy.

A study was carried out on the patient population of two cerebral palsy facilities serving Northeast New York State to evaluate obstetric factors which might be associated with the development of cerebral palsy. A combination of available medical records and a maternal questionnaire was used for analysis. Of 605 contracted, 158 mothers (26%) provided valid and detailed data, and the study was confined to these 158 patients. A positive association was found with increased reproductive loss, prematurity, and vaginal breech delivery. The need to develop and adopt a comprehensive uniform record system for the pregnant patient and her child is underscored. The limitations of a single factor retrospective study are acknowledged.

ABO Blood-Group System↗

PubMed1976

Antepartum fetal arrythmia. A case report.

On a number of occasions fetal heart arrythmias have been detected during the course of routine antepartum patient examination. A case is presented to illustrate the difficulty of making a definitive diagnosis of the nature of the arrythmia, and its significance in relation to fetal status. Investigation included stressed and nonstressed FHR monitoring, but a definitive diagnosis could not be made during the antepartum period and the patient could, therefore, not be assured of the essentially benign nature of the arrythmia until shortly after the birth of her child. The electrocardiogram obtained from external fetal electrocardiographic monitoring is not sufficiently refined to aid in the antepartum diagnosis of fetal cardiac arrythmias.

Adult↗

PubMed1976

Obstetric care in a family health-oriented university associated neighborhood health center.

The structure, staffing, and planning methods of the obstetric component of a family-oriented University Hospital associated family health care facility are briefly described. The interviews and screening procedures are outlined necessary to develop a broad data base for total health care planning. The roles of the members of the multiprofessional team employed are described with particular emphasis on the use of a nurse midwife as the primary obstetric care professional. Management procedures are referred to as well as the educational component present within such a program. The program is evaluated in terms of clinical outcome, patient and professional acceptance, and cost.

Adolescent↗

PubMed1974