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Biomedical subjects

M Bächle

Publications and source records attributed to M Bächle.

4 recordsLinked to original sources
PubMed2006

Structure and in vitro cytocompatibility of the gastropod shell of Helix pomatia.

Distinguishing features of biological constructions are high stability and adaptation to their environment. Beside biocompatibility, nontoxicity and degradability these characteristics are demanded for new biomaterials in the field of tissue engineering. This study investigated the chemical composition, the organization and the in vitro osteoconductive potential of the terrestrial gastropod shell (Helix pomatia) on CAL72 and human osteoblast-like cells. Chemical composition of the biomaterial was examined by X-ray diffraction (XRD) and scanning electron microscopy (SEM) was performed to analyze the architecture of the snail shell and the morphology of the seeded cells. A double staining procedure (FDA/PI) and a proliferation test (EZ4U) assessed the viability of the cells. Microscopical images showed the multilayered architecture of the aragonite shell with hexagonal crystals on the inner side. The cells spread well on the biomaterial and the highest proliferation rate could be measured with CAL72 cells on the inner shell surface. The osteoconductive effects of this natural biomaterial could encourage further experiments in the field of tissue engineering.

Animals↗
PubMed2006

[Prosthetic treatment of a six-year-old child with hypodontia. A case report].

The prosthetic treatment of young patients with congenital missing of several teeth is a challenge for the dentist. An early prosthetic management with regard to function, phonetics, esthetics is important to ensure a normal psychological development of these children and to promote a normal tooth and jaw development. On the basis of this case report about the prosthetic rehabilitation of a 6-year-old patient with congenital hypodontia of the primary and the permanent dentition, we give an overview of the literature available about this topic. A restorative dental management with removable prosthodontic appliances is described, and the prosthetic therapeutic alternatives are discussed.

Anodontia↗
PubMed2001

[Guided bone regeneration around dental implants using a bioabsorbable membrane. A pilot investigation in experimental animals].

The aim of this experimental investigation was to evaluate the effect of guided bone regeneration around immediately placed implants using different barrier membranes. Five adult fox hounds were used in this investigation. After extraction of all premolars in the lower jaw, implant osteotomies in the regions of the former premolars and additional buccal bone defects (5 mm x 5 mm) were created. Subsequently, the implants were placed. The defects were treated with one of the following three modalities: (a) guided bone regeneration, using a bioinert expanded polytetrafluoroethylene membrane, (b) no membrane application and (c) guided bone regeneration, using a bioabsorbable membrane made from a synthetic copolymer of lactide and glycolide. After a healing period of six months, the animals were sacrificed and the implants with the surrounding tissues processed for histologic evaluation. The clinical pretreatment defects between the different treatment groups were not statistically different (bioinert membrane group: 4.8 mm; control group: 4.3 mm; bioabsorbable membrane group: 4.9 mm). The remaining histological defects after a healing period of 6 months amounted to 3.2 mm for the nonresorbable group, to 5.6 mm for the control and to 6.3 mm for the bioabsorbable group. A significant difference was observed between the bioinert membrane group and the other two groups. The mineralized bone-to-implant contact in the bioinert membrane group was 52%, in the control group 47% and in the bioabsorbable membrane group 43.3%. The values were not statistically significant different. The results of this study indicate that a partial bone regeneration with bioinert e-PTFE membranes around immediately placed implants is possible. The utilized bioabsorbable polylactide/polyglycolide membrane did not show any bone regenerative effect, and the results did not differ from the control group without membrane application.

Absorbable Implants↗