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Biomedical subjects

M Bagot d'Arc

Publications and source records attributed to M Bagot d'Arc.

At least 19 recordsLinked to original sources
PubMed2003

[Intravenous immunoglobulin (Endobulin) clinical tolerance: prospective therapeutic follow-up of 142 adults and children].

PURPOSE: Prospective report of Endobulin clinical tolerance experience for 19 months over a large number of patients. METHOD: Collect diagnosis, age, gender, weight, dose regimen, infusion duration, and clinical tolerance of Endobulin. Treatment with this product was the only inclusion criteria in this follow-up. RESULTS: A hundred and forty-two patients, 85 children and 57 adults, mean age 23 (1-85 years) received 70 substitutive treatments for primary immunodeficiency, 36 substitutive treatments for secondary immunodeficiency and 36 immunomodulatory treatments. A thousand six hundred and sixty Endobulin infusions that led to 14, 061.5 g, from 52 different batches. Tolerance was judged as good for 135 patients even though side effects occurred in 2 of them. Thus, 133 out of 142 patients, that is 93.7% did not present any side effect and their tolerance to Endobulin infusions was defined as good. Tolerance was bad for 7 patients because of side effects occurrence. For a mean number of 11.7 infusions per patient (1-31), the 9 side effects observed led to a rate of 0.54% of collected infusions and 6.3% of patients included. CONCLUSION: This therapeutic follow-up of 142 patients confirms Endobulin clinical tolerance judged as good in 93.7% of patients (133/142) with a very low rate of side effects of 0.54% of infusions (9 side effects for 1660 infusions) for a mean number of 11.7 infusions per patient for an average of 10.9 months follow-up.

Adolescent↗
PubMed1998

[The otolaryngologist and Creutzfeldt-Jakob disease].

Is the ENT surgeon guilty of being a vector in Creutzfeldt-Jakob disease (CJD) in the past, present and future, with possible medico-legal implications, by virtue of his use of biomaterials and of his failure to sterilise surgical instruments adequately? Once the disease has been diagnosed, are there any implications for ENT? CJD is the most frequent clinical manifestation of the infectious subacute spongiform encephalopathies. It is invariably fatal within a few months, and at present there is no known treatment. Currently the diagnosis can be confirmed only by brain biopsy, but diagnostic tests are being developed. The causative agent belongs to the group of non-conventional transmissible agents, or prions, which are resistant to all conventional sterilisation methods. The illness has a long incubation period extending to several years, during which the abnormal prion protein (PPr), derived from a protein which is normally present, accumulates in the central nervous system. CJD is a rare condition, affecting less than one in a million of the population, and manifests itself in one of three distinct ways: sporadic, in 90% of cases, possibly due to a natural mutation of the gene responsible for formation of the protein, hereditary familial (5 to 10% of cases); and iatrogenic, transmitted by the implantation of biomaterials of human origin, which are the cases for which the ENT surgeon could be responsible, and which may affect any age group. The possible modes of ENT transmission have been identified. These could be the use of surgical material contaminated by a patient suffering from CJD, the use of human biomaterials whether dural homografts, ossicular homografts taken together with the donor dura, the use of blood products, or the use of biomaterials of bovine origin. Such materials have been used widely in the past without any observed increase in new CJD cases, but the incubation period of this disease is not well understood. A knowledge of the possible alternatives and of the new relations on the subject should allow us to improve the epidemiology of the condition, help the surgeon in his choice of materials, help in the diagnosis of the condition, and in avoiding its transmission by heeding new advice on sterilisation.

Creutzfeldt-Jakob Syndrome↗
PubMed1992

Macroporous biphasic calcium phosphate efficiency in mastoid cavity obliteration: experimental and clinical findings.

Following our previous experimental studies on the performance of macroporous biphasic calcium phosphate (MBCP) in canine mastoid cavities, we used this material in patients requiring surgical intervention. Twenty-two cases were selected, and in eight specific cases a biopsy specimen was taken. Histologic, ultrastructural, and microanalysis studies were performed. This study demonstrates the effectiveness of MBCP implants as bone graft substitutes for mastoid cavity obliteration. Clinical evaluation of the series and histologic and ultrastructural results demonstrated the bioactivity and osteo-conduction of this material, with partial transformation of MBCP granules into lamellar bone after several months.

Adolescent↗
PubMed1990

[Anastomosis of the facial nerve using fibrin glue, apropos of 60 cases].

The facial nerve was repaired with only fibrin glue anastomosis in 60 cases. The facial nerve was repaired by end-to-end (21 cases) or cable graft (28 cases) anastomosis. In 11 cases, a hypoglosso-facial anastomosis was performed. Grade 3 facial regeneration was observed in 62% of cases after one year follow-up. End-to-end or cable graft anastomosis provided the best results when the anastomosis were glued into the petrous bone or the parotid. The anastomosis should be performed without tension and the vascularization of nerve should be preserved if possible.

Facial Nerve↗
PubMed1987

[Are auditory prostheses a contraindication to magnetic resonance imaging?].

Prior to the use of nuclear magnetic resonance imaging (NMRI) in patients with metallic ossicular prostheses their compatibility must be investigated with the intense magnetic fields generated by NMRI. Implanted auditory prostheses are an absolute contraindication to NMRI, but an experimental study of its possible interaction with metallic stapedial prostheses has shown absence of their displacement. The artefact induced may alter images of middle ear but do not affect internal auditory canal. Nevertheless, manufacturers should conduct tests of magnetism of prostheses before they are passed as satisfactory.

Cochlear Implants↗