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M Balíková

Publications and source records attributed to M Balíková.

24 records · Page 2Linked to original sources
PubMed1988

Rapid determination of ethylene glycol at toxic levels in serum and urine.

The rapid gas chromatographic detection and determination of ethylene glycol in biological fluids is described. Phenylboronic acid in acetone was used for the esterification of glycol. The phenylboronates of ethylene glycol and 1,2-propylene glycol are not separated on a packed column of medium polarity (OV-17), but they can be separated on a non-polar column (OV-101). In both instances, 1,3-propylene glycol can be used as an internal standard. The method requires only 100 microliters of serum or urine and is suitable for trace analysis in an emergency toxicological laboratory. The utility of the method is demonstrated on two cases of human intoxication with ethylene glycol.

Child↗
PubMed1987

Pharmacogenetic study with diazepam in twins.

In a study with healthy volunteers (6 monozygotic and 4 dizygotic twin pairs) we followed up diazepam serum levels and psychotropic effects of diazepam after single-dose administration. We found that pharmacokinetic properties of diazepam as well as its influence on memory and performance are probably not under genetic control. On the other hand, genetic factors seem to contribute to effects of diazepam on affectivity.

Adult↗
PubMed1983

[Contribution to the kinetics of ethanol absorption and elimination in the presence of hydrocarbons (n-hexane) in the rat].

Increased ethanol blood level follows the administering of ethanol mixed with single hydrocarbons in a similar way as after cannulation of ethanol with benzol Ethanol blood level changes are stipulated by hydrocarbons, reducing benzol compounds are not decisive for increasing influence. Kinetic relations indicate that resorption speed is not influenced substantially. Increased ethanol blood level in rat seems to be caused by restricted elimination.

Animals↗