Sweet's syndrome and acute myelogenous leukemia in a patient who presented with a sudden massive swelling of the tongue.
We report a case of Sweet's syndrome in a patient in whom an acute myeloblastic leukemia was subsequently diagnosed. Approximately 10-20% of the reported cases of Sweet's syndrome occur in patients with a malignancy, the neoplastic condition most commonly reported being acute myelogenous leukemia. This case is of interest because of its unusual clinical presentation: the cutaneous lesions were accompanied by a massive swelling of the tongue. We suggest that this sudden macroglossia was caused by an infiltration of mature neutrophils, as seen in cutaneous lesions of Sweet's syndrome. There have been several reports recently of extracutaneous manifestations of Sweet's syndrome, and neutrophilic infiltrates have been found both in several internal organs and at mucosal locations.