Biomedical subjects

M Baranowska

Publications and source records attributed to M Baranowska.

At least 19 recordsLinked to original sources

PubMed2006

Potential involvement of a propranolol-insensitive atypical beta-adrenoceptor the vasodilator effect of cyanopindolol in the human pulmonary artery.

The aim of our study was to examine whether non beta(1)-/beta(2)-adrenoceptors participate in the relaxation of the human pulmonary artery. For this purpose the vasodilatory effect of the non-conventional partial beta-adrenoceptor agonist cyanopindolol was examined. Cyanopindolol (1-300 microM), studied in the presence of the beta(1)-/beta(2)-adrenoceptor antagonist propranolol, relaxed the human pulmonary artery preconstricted with serotonin 1 microM in a concentration-dependent manner (maximally by about 80%). This effect was diminished by bupranolol 10 microM (an antagonist of beta(1)-beta(3)-adrenoceptors and the low affinity state of the beta(1)-adrenoceptor) and CGP 20712 10 microM (known to antagonize the low-affinity state of the beta(1)-adrenoceptor at high concentrations). In further experiments, the effect of beta-adrenoceptor ligands on the serotonin-induced vasoconstriction was examined. The concentration-response curve for serotonin was not affected by cyanopindolol 30 microM, bupranolol 10 microM and CGP 20712 10 microM but shifted to the right by cyanopindolol 100 and 300 microM; the serotonin 5-HT(2A) receptor antagonist ketanserin 0.3 microM abolished the maximum contraction elicited by serotonin. In conclusion, the present study reveals that the vasodilatory effect of cyanopindolol in the human pulmonary artery consists of two components, i.e. activation of a propranolol-insensitive atypical beta-adrenoceptor and antagonism against 5-HT(2A) receptors.

Adrenergic beta-Antagonists↗

PubMed2001

[Foreign body in the right frontal lobe of the brain as a result of right eyeball and right eye-socket trauma--case report].

We report a case of a 44 year old man, who was admitted to our hospital because of right eyeball and right eye-socket due to a piece of diamond circular saw. Right eyeball was sutured. CT--examination showed a metallic foreign body in the right frontal lobe of brain. Metallic foreign body, which damaged the right eyeball, caused upper restriction of right eye-socket ceiling and stuck in a frontal lobe of the brain was removed.

Accidents, Home↗

PubMed2000

[Content of nitrates and nitrites in raw mild in different regions of the country].

The content of nitrates and nitrites in raw milk in different regions of the country was studied. The results obtained dependent both on the factory from which the samples origin and on the seasons of the year. In 37% of samples there was insignificant increase in the level of nitrates, and in 31.9 of nitrites.

Animals↗

PubMed1998

The effect of degree of whey protein denaturation and conditions of milk preparation on functional properties of yoghurt (short communication).

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Animals↗

PubMed1991

[Effect of isoprinosine and acyclovir on the clinical course of chickenpox and herpes zoster].

The therapeutic effect of isoprinosine and acyclovir have been studied in 352 and 284 patients with chicken-pox and herpes zoster respectively. The patients were divided into 4 groups: the first one was given palliative treatment only, the second--both palliative and isoprinosine ones, the third--palliative and acyclovir treatment, and the fourth group was given all these. The best therapeutic effect was achieved when acyclovir and isoprinosine was applied jointly, the one of acyclovir alone was less pronounced and that of isoprinosine only was the smallest. According to the authors acyclovir should be the treatment of choice in the very severe and severe cases of chicken-pox and herpes zoster; in the early stage of disease it should be supplemented with isoprinosine and passive immunotherapy.

Acyclovir↗

PubMed1991

[Etiology, clinical course, and the methods and results of the treatment of suppurative meningoencephalitis in adults--personal observations data].

The authors discuss problems connected with the clinical, aetiological diagnosis, methods and results of treatment of purulent meningoencephalitis in adults. The basis for the discussion were own experiences obtained during hospitalization of 578 patients in the period 1981-1990. As a results of this analysis the authors found that the organisms causing this disease most frequently were, as previously, Neisseria meningitidis and anaerobic Haemophilus influenzae were still highly unsatisfactory. Complete recovery was obtained in 73.3% of cases, 6.6% were discharged with various neurological sequelae, and 29.1% died. Cases of pneumococcal origin, frequent after cranial trauma, showed the most severe course, had the highest percent of psychoneurological complications and recurrences with the highest death rate.

Adolescent↗

PubMed1987