M Barbet | PubMed Health

PubMed1983

[Captopril-induced eruptions: occurrence over a 3-year period].

With an informatized sample of 123 patients taking Captopril and treated for a total duration of 1,321 month/patients, the frequency of the dermatological symptoms induced by the drug is related. Pruritus is found in 10,5 p. 100 and rashes in 2,4 p. 100 of cases. The results are compared with those of preceeding reports, although some authors have found a higher percentage because of highin doses of the drug. The clinical features of the rashes and the proposed mechanisms are also reported.

Adult↗

PubMed1983

[Captopril induced lichenoid eruption].

The authors report three cases of Captopril induced lichenoid eruption, already unmentionned, as far as they know. This cutaneous adverse reaction seemed to be dose related. Late onset was possible, even after six months of therapy. Violaceous papules or plaques were localized (two cases) or disseminated (one case) on the skin. The oral cavity was spared, but mucous membrane may be involved (localisation on the glans penis in one case). Histopathology was suggestive of lichen, but cellular dermal infiltrate was rather sparse. Immunofluorescent study in one case showed anti-IgM and C4 deposits on dermal colloid bodies. Captopril withdrawal was followed by improvement. Reviewing the literature, the authors are questionning about the fact that chemical structures of Penicillamine, Pyritinol and Captopril are strikingly similar and perhaps causative.

Adult↗