Biomedical subjects

M Basha

Publications and source records attributed to M Basha.

5 recordsLinked to original sources

PubMed1998

Morbidity among farm workers in a desert country in relation to long-term exposure to pesticides.

OBJECTIVES: Farm workers chronically exposed to low levels of pesticides seldom show signs and symptoms of clinical significance. This study investigates subclinical morbidity patterns among male farm workers in a desert country. METHODS: Migrant-established farm workers (N=226) were compared with referents (N=226) and with new farm workers (N=92) who had just entered the country to work on farms. Acetylcholinesterase activity was measured, the aiming test and digit symbol test were applied, and a morbidity profile was collected with a questionnaire. RESULTS: The erythrocyte acetylcholinesterase activity and hemoglobin-adjusted erythrocyte acetylcholinesterase activity were significantly depleted in the established farm workers. The results of the aiming and digit symbol tests were also significantly lower for the established farm workers. For the morbidity profile, irritated conjunctiva (47.3%), watery eyes (52.2%), blurred vision (63.3%), dizziness (55.2%), headache (63.7%), muscular pain (61.1%), and weakness (76.6%) were reported by established farm workers in statistically significantly higher numbers than by the referents and new farm workers. CONCLUSIONS: Morbidity patterns, such as the health complaints and objective parameters suggested in this study, would be suitable as criteria for identifying farm workers most at risk from pesticide toxicity and as criteria for initiating measures to control and reduce exposure.

Acetylcholinesterase↗

PubMed1997

Optimum duration of feed and water removal prior to processing in order to reduce the potential for fecal contamination in turkeys.

Feed and water withdrawal (FWW) prior to processing of poultry is an efficient and commonly employed method to attempt to reduce contamination of carcasses by contents of the gastrointestinal tract during processing. This study indicated that 4 h of FWW is as good as 8 or 12 h in reducing both water and dry matter content of the tract of market age turkeys of both sexes. This duration of FWW also minimizes shrinkage of the carcass.

Animals↗

PubMed1997

Interaction between tacrolimus and erythromycin.

A 40-year-old Asian man, 6 months post renal transplant and receiving tacrolimus therapy, presented to the emergency department with a complaint of sudden-onset left eye pain with blurred vision, headache on the left side, and nausea and vomiting. On being admitted, the patient was intubated for respiratory depression, and erythromycin was initiated for suspected atypical pneumonia. Tacrolimus concentrations (whole blood) drawn on the 3rd day of hospitalization were reported to be > 60.0 ng/ml. Before hospitalization, tacrolimus concentrations were reported to be 9.8 ng/ml on a maintenance dose of 7 mg twice daily. Six days after discontinuation of erythromycin and a decrease in tacrolimus dose, the concentration decreased to 11.5 ng/ml and the original dose of tacrolimus was restarted. It is recommended that concurrent administration of erythromycin and tacrolimus be avoided. However, if concomitant therapy is necessary, tacrolimus concentrations, serum creatinine, blood urea nitrogen, and urine output should be monitored.

Adult↗

PubMed1991

Interleukin-1 induced gene expression of neutrophil activating protein (interleukin-8) and monocyte chemotactic peptide in human synovial cells.

We report here that human synovial cells stimulated by interleukin-1 alpha and interleukin-1 beta express mRNA for both IL-8 (neutrophil chemotactic peptide) and monocyte chemotactic protein. IL-1 stimulated synovial cells from both osteoarthritis and rheumatoid arthritis patients exhibited similar mRNA expression of interleukin-8 and monocyte chemotactic protein. A capacity to produce factors selectively chemotactic for neutrophils, lymphocytes and monocytes provides a mechanism whereby synovial cells can facilitate inflammatory arthritis.

Blotting, Northern↗

PubMed1990

Tumor necrosis factor-alpha, interleukin-8 and chemotactic cytokines.

There is little doubt that the high degree of communication observed during an immune response occurs via sophisticated cell-to-cell mediator circuits. The coordinate expression of specific signals are needed to orchestrate inflammation as the lesion is initiated, maintained, and finally resolved. Each of these phases can be viewed as a unique window of inflammation that is driven by a specific set of mediators. In this manuscript, we have developed the concept that cytokine-cytokine interactions play a prominent role in the elicitation of inflammatory cells. Our data demonstrate that the expression of chemotactic cytokines are both cell and stimulus specific. Interleukin-8, neutrophil chemotactic factor, can be synthesized by a variety of immune and non-immune cells, but the production is dependent upon an appropriate challenge. The production of monocyte chemotactic factor is much more cell restricted and appears to be generated in abundance by only non-immune cells (fibroblasts, endothelial cells, and epithelial cells). These data suggest that the recruitment of cells to a site of inflammation is dependent upon the expression of specific cytokines for both the induction and maintenance of the lesion.

Animals↗