PubMed Health⌕ Search

Biomedical subjects

M Basista

Publications and source records attributed to M Basista.

28 records · Page 2Linked to original sources
PubMedDate not supplied

[Use of nitrendipine in treating patients with obliterative atherosclerosis of arteries in the lower extremities].

Twenty patients with obliterative atherosclerosis in the lower extremities arteries (Fontaine's stage II) were treated with nitrendipine (Bayotensin) given in the dose of 20 mg daily for 6 weeks. This therapy with nitrendipine produced improvement manifested by the prolongation of the distance of intermittent claudication, shortening of pain duration, increase in blood flow in the ischemic extremity, and increase in pressure index. At the same time, nitrendipine decreased ADP-produced platelet aggregation and activated fibrinolytic system. Clinical trials have shown that nitrendipine is effective in the obliterative atherosclerosis in the lower extremities.

Adult↗
PubMedDate not supplied

[Kallikrein in the treatment of patients with obliterative atherosclerosis of the lower limbs and its mechanism of action].

Kallikrein (Padutin-Depot) was administered to 20 patients with obliterative atherosclerosis of the lower limbs of the II degree (19 patients) and IV degree (1 patient). The drug was given in the daily dose of 40 U i.m. for 28 days. An effect of kallikrein on the distance in intermittent claudication, rate of pain relieve after walking the maximal distance, blood flow in the lower limbs, and on the index of circulating aggregates have been determined. Clinical improvement has been noted after a 4-week therapy with kallikrein. The drug in a single dose of 40 U activates plasma fibrinolytic system for 5 hours and decreases the number of circulating aggregates (2-5 h). The authors explain kallikrein action as the release of endogenous bradykinin, which subsequently releases two epithelial mediators, i.e. PFG1 and EDRF.

Adult↗
PubMedDate not supplied

[Effect of Polish antacids on prostaglandin E2 values in gastric mucosa].

An effect of the locally produced antacids on PGE2 in the gastric mucosa has been studied both clinically and experimentally. It was found, that such preparations as Alugastrin, Gastrin, and Vikalin administered chronically to the rats accelerate healing rate of peptic ulcer, decreasing in the same time the PGE2 level in the gastric mucosa. Alugastrin in a single oral dose significantly increased pH of the stomach and did not affect endogenous PGE2 level. Some locally produced antacids exert an effect on endogenous PGE2 production in the gastric mucosa, which could be important for their efficacy.

Adult↗
PubMedDate not supplied

Plasma antioxidant potency and serum copper levels in atherosclerosis.

Blood plasma of patients with arteriosclerosis obliterans and diabetes showed a higher antioxidant potency as compared with plasma of healthy volunteers. Serum copper level in those patients was also elevated, but on the contrary to healthy subjects no correlation between serum copper level and plasma antioxidant potency was found. Similar changes were observed in rabbits fed four weeks with atherogenic diet. Administration of vitamin E increased plasma antioxidant potency, however, only in the patients suffering from arteriosclerosis obliterans with high regime of dosage of vitamin E (3 X 200 mg daily p.o.). N-ethylmaldimide-stimulated (malondialdehyde (MDA)) generation by washed platelets was suppressed by addition of homologous plasma to washed platelet preparation. Preincubation of rat aortic tissue with plasma from healthy volunteers resulted in an increase in PGI2-biosynthesis b 75%. We were not able to demonstrate the antioxidant activity of aortic endothelial cell homogenates. We conclude that antioxidant properties of plasma may play an important role in protection of serum lipids against autooxidation. Antioxidant ability of plasma is not exclusively correlated with plasma copper or ceruloplasmin level.

Adult↗
PubMedDate not supplied

Selective inhibition by fenflumizole tissue cyclooxygenase in rabbits ex vivo.

A new non-steroidal anti-inflammatory drug fenflumizole when administered orally to rabbits at therapeutic doses of 10 and 30 mg/kg affects neither PGI2 generation by arterial slices nor PGE2 generation by gastric mucosa, respectively. Fenflumizole at doses of 10 and 30 mg/kg per os inhibits platelet aggregability and generation of TXA2 by platelets. It is suggested that this selective action of fenflumizole on tissue cyclooxygenase ex vivo may justify with fenflumizole in anti-thrombotic therapy.

Animals↗
PubMedDate not supplied

Inhibition of arterial PGI2 generation and platelet aggregation by aspirin in rabbits ex vivo.

In 63 rabbits the generation of prostacyclin (PGI2) by coeliac and mesenteric arteries and arachidonate-induced platelet aggregation in platelet rich plasma (PRP) were studied at 24th, 48th and 72nd hour after oral administration of single doses of acetyl salicylic acid (ASA) (15, 25 and 50 mg/kg). Only at the lowest dose ASA caused a selective inhibition of platelet cyclo-oxygenase. ASA at this dose had a cumulative inhibitory effect on arterial cyclo-oxygenase when it was administered in an ineffective single daily dose during three days every 24h. It is concluded that in vivo ASA can be hardly considered as a preferential inhibitor of platelet cyclo-oxygenase.

Animals↗