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Biomedical subjects

M Baykal

Publications and source records attributed to M Baykal.

At least 19 recordsLinked to original sources
PubMed1992

[Typing by isoelectric focusing of beta-lactamase enzymes in Klebsiella and Enterobacter strains resistant to the new beta-lactam antibiotics].

Resistance to new generation beta-lactam antibiotics in Gram-negative bacteria is increasing worldwide. This resistance is due to EBS enzymes in Klebsiella spp., and Type-I chromosomal enzymes in Enterobacter spp., Citrobacter, P. aeruginosa, Providencia, M. morganii and S. marcescens. In this study, the types of beta-lactamases in 16 Klebsiella spp. and 15 Enterobacter spp. which are resistant to newer beta-lactam antibiotics was investigated by isoelectric focusing. The results of the study showed that TEM-1 enzymes are prevalent in these isolates. pI (isoelectric point) values and antibiotic susceptibility test results suggest that there are EBS enzymes in Klebsiella spp., and Type-I enzymes in Enterobacter spp. These results have to be supported by further investigations.

Anti-Bacterial Agents↗
PubMed1992

[Staphylococcal biotyping and the use of computers].

Ninety coagulase negative staphylococci isolated from various clinical specimens in Clinical Microbiology laboratory of Hacettepe University Faculty of Medicine, were biotyped using a special computer program. Types of 30 strains isolated from pus were found to be S. epidermidis (36.7%), S. haemolyticus (20%), S. simulans (13.3%) and S. hominis (10%) respectively. Among the strains isolated from blood S. epidermidis was again the predominant microorganism (40%), followed by S. haemolyticus (20%) and S. simulans (10%).

Bacteremia↗
PubMed1991

Campylobacter and enterohaemorrhagic Escherichia coli (EHEC) associated gastroenteritis in Turkish children.

From May 1989 to April 1990, stool specimens of 677 children less than 15-years old who were admitted to the Hacettepe University outpatient department of Pediatrics with acute enteritis were collected to search for four common enteric pathogens: Salmonella, Shigella, Campylobacter, and enterohaemorrhagic Escherichia coli (EHEC). At least one of the three bacteria was detected in 107 (15.8%) of the patients. Campylobacter was found in 72 (10.6%) of the samples. Shigella and Salmonella spp. were isolated in 26 (3.8%) and 11 (1.6%) children respectively. EHEC was not isolated from any of the stool samples. None of the 100 healthy children examined as a control group yielded any of the four pathogens in their stools. Campylobacter should be considered as an important aetiological agent of diarrhoeal diseases in Turkey, where EHEC is not a common pathogen.

Acute Disease↗
PubMed1990

[In vitro activity of aztreonam, cefoperazone and ceftriaxone against gram-negative bacteria].

In this study, the in vitro activity of aztreonam was compared with that of cefoperazone and ceftriaxone against 1000 gram-negative bacilli. Among gram-negative bacteria, resistance to aztreonam, cefoperazone and ceftriaxone were noted 2.7%, 11.3%, 11.5% respectively. The results obtained in this study indicate that aztreonam is highly effective against gram-negative bacilli.

Aztreonam↗
PubMed1990

[Comparison of the in vitro antibacterial activity of ofloxacin and nalidixic acid].

The in-vitro activity of ofloxacin and nalidixic acid was determined against 964 Gram-negative and 66 Gram-positive isolates from different clinical specimens. Ofloxacin showed excellent in vitro activity against Enterobacteriaceae. The compound was significantly more potent than nalidixic acid against Pseudomonas spp. Acinetobacter spp. and Staphylococcus spp. We conclude from our studies that ofloxacin could be a valuable therapeutic agent with a variety of indications.

Acinetobacter↗
PubMed1990

[Group B streptococcal endocarditis].

In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immunosuppressive therapy because of dermatomyositis is reported.

Dermatomyositis↗
PubMed1989

[In vitro antibiotic susceptibility of staphylococci].

In this study in vitro activities of different antimicrobial drugs against 1000 staphylococci were evaluated. Tested staphylococci were isolated from the clinical material of out patient and in patient sections. Susceptibility tests were done according to NCCLS Disk Diffusion Technic. The antimicrobial drugs evaluated in this study were; Vancomycin, ofloxacin, sulbactam-ampicillin, co-trimoxazole, tetracycline, erythromycin, tobramycin, methicillin, first and third generation cephalosporins and penicillin. Vancomycin was the drug of choice against resistant staphylococci. Ofloxacin, sulbactam-ampicillin, first generation cephalosporins and some aminoglycosides were more effective than others.

Aminoglycosides↗
PubMed1988

[The identification and comparison of gram-negative Enterobacteriaceae and non-fermentative bacteria by the conventional manual method and the Quantum II microbiology system].

In this study a total of 1065 clinically isolated enteric and non-fermentative bacteria were tested and compared with a commercially manufactured "Quantum II Microbiology System", and the conventional manual biochemical tests. We are able to say that, "Quantum II Microbiology System" will be very useful in clinical laboratories due to making an identification in a very short time and in species level when an attentive study is made.

Bacteria↗
PubMed1988

[Resistance of gram negative bacteria to new generation cephalosporins and the role of beta-lactamases in this type of resistance].

In this study, by using the microbroth dilution method, in vitro susceptibilities of gram negative bacteria to new generation cephalosporins were examined, and among these, 40 bacteria which showed resistance against at least two antibiotics were tested for beta-lactamase production. Beta-lactamase production was positive in all of them. However, this type of resistance could not be transferred to susceptible recipients by conjugation experiments. Our results suggest that the resistance to beta-lactam antibiotics in these strains are related with chromosomally mediated beta-lactamases.

Cephalosporins↗
PubMed1987

[Comparison of the in vitro effectiveness of sulbactam/ampicillin and ampicillin].

In this study, we compared the effectiveness of Sulbactam + Ampicillin compound and Ampicillin against to 1168 clinical isolates by means of disk diffusion technic. We observed that Sulbactam + Ampicillin compound is enhanced and regained the antibacterial activity of Ampicillin against some bacteria such as S. aureus, S. epidermidis and some gram negative microorganisms.

Ampicillin↗
PubMed1987

[Fluoroquinolones].

We reviewed, the structure, pharmacokinetic properties, mode of actions, antibacterial spectrum, therapeutic dosage and side effects of fluoroquinolones in this article.

Bacteria↗
PubMed1986

[Immunoelectrophoretic analysis of Escherichia coli strains (EPEC, ETEC, EIV and UPEC) (1)].

Water extracts of Escherichia coli "O" and "K" antigen test strains (EPEC, ETEC, EIEC, UPEC) were examined in immunodiffusion and immunoelectrophoresis tests. The precipitation arcs corresponding to the O-antigen specificity and to the thermostable polysaccharide K antigen were easy to identify. All strains gave an O antigen precipitation arc found either on the anodic or the cathodic side of application basin and close to this. The so-called enteropathogenic types (from infantile diarrhoea) had a cathodic O antigen arc type; from dysentery-like disease had a negatively charged O-antigen, but no special thermostable K-antigen. Thus E. coli strains which may invade the tissues when conditions allow have a negatively charged surface antigen, either O-antigen lipopolysaccharide or both. Acidic components were found in the anodic O-antigen.

Antigens, Bacterial↗
PubMed1986

[Aminoglygoside nephrotoxicity].

Aminoglycoside nephrotoxicity is a big problem to all physicians and patients. In this review, prevention of nephrotoxicity, monitoring of the aminoglycoside therapy and also clinical laboratory findings during therapy are discussed.

Aminoglycosides↗
PubMed1982

[Amikacin - resistance in some bacteria isolated in Ankara, and its relation to R plasmids].

Four acinetobacter and 5 Ps. aeruginosa strains which were isolated in Clinical pathology Lab. of Hacettepe Univ. Med. School, and found to be resistant to Amikacin were tested for infectious drug resistance, using conventional in vitro transfer technique repeatedly. E. coli K12 Nalr (for Acinetobacters), and Ps. aeruginosa (for Pseudomonads) strains were used as recipients. For cultures and transfer experiments NB No : 2, and for the selection Mc Conkey Agar plates with nalidixic acid and proper antibiotics were used. Inspite of some variable and curious positive findings, it was not possible to transfer Amikacin - resistance to recipients with certainty. Results suggest that this characteristic was not controlled by R plasmids and hence was not "infectious", or at least could not been transferred by the technique we used.

Acinetobacter↗