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Biomedical subjects

M Beaudry

Publications and source records attributed to M Beaudry.

28 records · Page 2Linked to original sources
PubMed1989

Temporal intermittent rhythmic delta activity (TIRDA) in the diagnosis of complex partial epilepsy: sensitivity, specificity and predictive value.

Temporal interictal rhythmic delta activity or TIRDA was found in 45 of the 127 recordings of patients with complex partial epilepsy (CPE) referred for both awake and sleep EEG. TIRDA was more abundant during drowsiness and light sleep; it occurred more characteristically as trains of 50-100 microv sinusoidal or saw-toothed 1-4Hz activity, recorded predominantly from anterior temporal regions. When occurring bilaterally and independently, TIRDA varied from side to side. TIRDA is often found in association with anterior temporal spikes or sharp waves (TS) particularly during sleep, as observed in 43 out of 45 EEGs. TIRDA can nevertheless occur as an isolated abnormality, as noted in two sleep and 12 awake study recordings. Because of its high specificity and positive predictive value over a large range of prevalence, TIRDA should be singled out as an accurate interictal indicator of CPE. In patients with isolated TIRDA, the cost of prolonged EEG recording during sleep for the purpose of activating TS has to be weighed against the yield of eventually confirming the obvious.

Adult↗
PubMed1989

Measurement of atherosclerosis: development of an atherosclerosis severity index.

Treatment of hypertension has succeeded in preventing the complications attributable to pressure, including heart failure and the arteriolar complications such as brain hemorrhage and renal failure. Recent understanding that antihypertensive drugs have effects on lipoproteins and flow disturbances that may be important in atherosclerosis progression, and the recent development of drugs that are more effective in treating hyperlipidemia, have given impetus to the design of studies to test whether interventions are anti-atherosclerotic. Since studies depending on clinical endpoints by necessity consume vast resources, it is desirable to develop methods for measurement of atherosclerosis, in order to make it possible to conduct intervention studies efficiently. Because angiographic methods are costly and associated with risk, and many patients are unable or unwilling to undergo followup angiography at the end of a study, we are developing an atherosclerosis severity index based on clinical and noninvasive ultrasound assessment. This scale can be used as a surrogate outcome in place of, or complementary to angiographic measurement of atherosclerosis, to avoid costly loss of subjects in intervention studies. It has the additional advantage that it is suitable for repeated assessment over time, permitting the power of analyses such as life table analysis which look at time to development of endpoints.

Angiography↗
PubMed1976

Umbilical cord cutting triggers hypertriiodothyroninemia and nonshivering thermogenesis in the newborn lamb.

The present studies in the newborn sheep were undertaken to further clarify the mechanism or mechanisms for the early increases in serum thyroid hormone concentrations in the newborn as well as the significance of these changes to newborn nonshivering thermogenesis. Six groups of animals were studied to determine the influence of neonatal cooling, cord cutting, and the effects of thyrotropin-releasing hormone (TRH) and triiodothyronine (T3) injections. Group I newborns were delivered into room air with immediate cord cutting. Group II animals were delivered into room air and cord cutting was delayed 60 min. Group II animals were delivered into a 39 degrees water bath and maintained for 60 min with the umbilical cord intact; the cord was cut at the time of removal from the water bath...

Animals↗
PubMedDate not supplied

The faculty portfolio: documenting the scholarship of teaching.

The scholarship of teaching is considered an essential component of scholarship within academic settings. To promote the transfer of knowledge specific to the discipline of nursing, this category of scholarship must include inquiry into the practice of teaching, program development, and professional role modeling, in addition to excellence in teaching itself. Conveying what constitutes teaching scholarship in nursing may present special challenges for nurse faculty in the university setting. A faculty teaching portfolio is one mechanism for explicating, communicating, and enhancing the scholarship of teaching. The methodology for creating, improving, and maintaining a teaching portfolio includes analyzing the mission of the university, articulating a philosophy of teaching, deciding on goals and objectives, designing evaluative mechanisms, processing data, conducting a self-evaluation, applying new approaches, and revisiting and reflecting on the outcomes. Faculty teaching portfolios serve to display, communicate, and document the scholarship of teaching. The creative endeavors surrounding portfolio development are ongoing and recursive, necessitating self-reflection and new approaches. J Prof Nurs 17:180-186, 2001.

Credentialing↗
PubMedDate not supplied

Method for the quantification of alginate in microcapsules.

Alginate is a key reagent in the preparation of microcapsules for cell transplantation. To address the question of the intracapsular alginate concentration, a sensitive assay has been developed to quantify the alginate content of microcapsules. The method is based on the metachromatic change induced by alginate binding to the dye, 1,9-dimethyl methylene blue (DMMB). The assay has a high sensitivity and precision. It covers a wide concentration range enabling the measurement of alginate in dilute supernatants as well as in microcapsules. For the latter, the membrane is initially dissolved by incubating the microcapsules in an alkaline medium. The effect of potentially interfering substances (poly-L-lysine (PLL), citrate, chloride, sodium) and of pH has been studied. Poly-L-lysine interfered with the assay at pH 6.5 but not at pH 13. Interference by sodium augmented with increasing sodium concentration and reached a plateau at 200 mM. This problem was overcome by routinely adjusting all samples to 500 mM sodium. The other substances tested had a negligible effect on the assay. The reliable measurement of alginate with this new assay will allow the optimization of the intracapsular alginate concentration.

Alginates↗
PubMedDate not supplied

[Preliminary results on the residence distribution at birth of patients with Alzheimer's disease in the Saguenay-Lac-Saint-Jean/Quebec (the IMAGE project)].

The IMAGE Project is pursuing the establishment of a population-based registry of Alzheimer's disease (AD) cases in the Saguenay-Lac-Saint-Jean (SLSJ) (Quebec). The authors report on the spatial distribution at birth of 221 possible, probable and definite cases. A large network of key-informants for screening AD cases has been established over SLSJ. The spatial distribution of cases at birth and at the onset of disease has been computed by calculating the Alzheimer birth rate (ABR) on the basis of three scales: six specific geographical spheres of screening, all municipalities, and the public health departments. The statistical significance of results was determined using the theoretical Poisson and the Chi square distributions. ABR for each of the geographical spheres of screening showed no statistically significant differences considering either residence at the onset of the disease or residence at birth. Furthermore, differences were observed between rural and urban areas with an interesting trend for a higher number of cases than expected in one area of SLSJ. The spatial distribution of cases considered on the basis of residence at birth appears to show a different pattern, but no significant, from that measured on the basis of residence at the onset of disease. Screening of cases is actively being pursued all across SLSJ by the IMAGE network. There is a clear trend towards rural residence at birth of cases. It remains to see whether or not this observation is due to a geographical concentration of familial cases.

Alzheimer Disease↗
PubMedDate not supplied

[Factors of successful breast feeding in New Brunswick: information and compatible working conditions].

Although breastmilk is the best food source for the first six months of life, breastfeeding rates at three and six months of age in New Brunswick are quite low. To determine action priorities to increase the duration of breastfeeding, we tried to identify its most important determining factors. Data were obtained from the 431 breastfeeding mothers in a representative sample of 777 infants born after a normal pregnancy. The mother's knowledge about breastfeeding is the most valuable factor that explains breastfeeding duration, followed by the compatibility of the mother's employment with breastfeeding. Interventions directed at improving either of these two factors should be encouraged particularly among mothers of lower socioeconomic status who breastfeed for shorter periods of time.

Breast Feeding↗
PubMedDate not supplied

Who breastfeeds in New Brunswick, when and why?

We studied infant feeding in a representative sample of primiparous mothers of six-month-old infants in New Brunswick in 1982-83. At birth, 56% of infants were breastfed, decreasing to 31% at three months and 16% at six months; fewer were breastfed, and this for shorter periods of time, among the French population, those of lower socio-economic status or younger mothers. Most of the mothers who did not breastfeed did not attend prenatal classes and almost half had decided before their pregnancy to breastfeed or not. Most mothers breastfed because they felt their milk was better. Bottlefeeding mothers were mainly motivated by its convenience.

Adult↗
PubMedDate not supplied

Dietary patterns of adults in Québec and their nutritional adequacy.

The purpose of this study was to identify dietary patterns among adults in Québec and to determine their relationship to nutritional adequacy of the diet. We used 24-hour food recall data on 2,104 adults from the Québec nutrition survey (1990). Nutritional adequacy was assessed based on the 1990 Nutrition Recommendations for Canadians; dietary patterns were assessed via a factor analysis of the 30 food groups consumed. The three major patterns identified ('high-energy density', 'traditional' and 'health-conscious') explained 18% of the variation in food intake. Only the 'health-conscious' pattern correlated positively with the four chosen indicators of nutritional adequacy. Generally, men scored positively on the 'high-energy density' and the 'traditional' pattern whereas women scored positively on the 'health-conscious' pattern. Aside from sex, scoring was most related to age and education. The use of these patterns to define and target nutrition interventions should be tested in the aim of improving the effectiveness of health promotion.

Adult↗