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Biomedical subjects

M Behr

Publications and source records attributed to M Behr.

61 records · Page 4Linked to original sources
PubMed1991

Expression of S14-mRNA and its translational product in differentiating 3T3-L1 cells.

During adipogenic conversion of 3T3-L1 cells S14-mRNA increased from undetectable levels in preadipocytes to high levels in differentiated adipocytes (adipocyte-like cells). In vitro translation of hybrid-selected S14-mRNA revealed an identical protein in 3T3-L1 adipocytes and in rat liver with regard to migration properties in two-dimensional gel electrophoresis. No translation product was found in 3T3-L1 preadipocytes. In conclusion, protein-S14 is very similar or even identical in rat lipogenic tissues and in 3T3-L1 adipocytes. Therefore, this cell line can be employed to elucidate further physiological aspects of protein-S14.

Adipose Tissue↗
PubMed1986

[Regression of myocardial hypertrophy in hypertensives on chronic beta-receptor block].

25 patients (24 males, 1 female; mean age 43.7 years), with previously untreated essential hypertension and echocardiographically proven left-ventricular hypertrophy, received metoprolol 200 mg daily over a period of 12.7 months, five of them additionally hydrochlorothiazide 25 mg. After four weeks, resting recumbent blood pressure had decreased from 157 +/- 18 systolic and 106 +/- 9 diastolic to 128 +/- 11 and 85 +/- 9, respectively; after 12.7 months to 123 +/- 12 and 83 +/- 8 mm Hg (P less than 0.001). On 100 W exercise the blood pressure fell from initially 206 +/- 13 and 117 +/- 9 168 +/- 12 and 97 +/- 9, after 12.7 months to 170 +/- 14 and 98 +/- 9 mm Hg. Left-ventricular mass fell from 147.0 +/- 26 g/m2 by 14% after 6.1 months, by 22.5% after 12.7 months (P less than 0.001). While the left-ventricular diameter in enddiastole and endsystole remained unchanged, septal thickness decreased from 15.5 +/- 2.1 to 14.2 +/- 2.2 mm after 6.1 months and 13.1 +/- 1.9 mm after 12.7 months (reduction of 15.5%). The corresponding values for the left-ventricular posterior wall were 11.9 +/- 1.6 before and 10.8 +/- 1.8 after 6.1 months and 10.1 +/- 1.4 mm after 12.7 months (reduction of 16%). Thus long-term administration of metoprolol resulted in a significant reduction in myocardial hypertrophy without impairment of ventricular function.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

Magnetic resonance of the disk of the temporomandibular joint. MR imaging protocol.

Disk displacement can be well detected using proton density-weighted and T2*-weighted two-dimensional gradient-echo sequences. In uncertain cases, especially if the bilaminar zone is not sufficiently represented, a contrast-enhanced T1-weighted spin-echo sequence should also be performed. Also in patients with disk degeneration and osteoarthritis of the temporomandibular joint, proton density-weighted and T2*-weighted two-dimensional gradient-echo sequences are of great diagnostic value. In this collective, however, T1-weighted contrast-enhanced spin-echo sequences should be generally performed, to demonstrate inflammatory reaction of the synovia.

Adolescent↗
PubMedDate not supplied

In vitro fracture force and marginal adaptation of ceramic crowns fixed on natural and artificial teeth.

PURPOSE: Artificial teeth made of acrylic resin or alloy are considered substitutes for rare caries-free human teeth in in vitro examinations. The purpose of this study was to compare the fracture strength and marginal adaptation of all-ceramic single crowns fixed to natural teeth with crowns fixed to artificial teeth after artificial aging. MATERIALS AND METHODS: The fracture force and marginal adaptation were investigated in 28 adhesively luted all-ceramic crowns on human molars of different sizes, as well as on alloy and liquid crystal polymer (LCP) artificial teeth. The fracture force was determined using a universal testing machine, and the semiquantitative marginal adaptation was examined using a scanning electron microscope, in both instances after simulating 5 years of clinical service. RESULTS: Fracture force was found to be significantly higher for crowns fixed on substitute materials (alloy = 1,838 N; LCP = 1,392 N) than for crowns on human teeth (888 N). No significant differences in marginal quality could be determined between the groups. All crowns showed marginal gaps of about 10% and perfect margins at about 90%. CONCLUSION: The high in vitro fracture values of all-ceramic crowns on artificial materials may lead to a misinterpretation of the tested restorative materials, overvaluing the material properties in a first preclinical estimation. Human teeth or materials with a comparable modulus of elasticity are therefore preferred in in vitro fracture tests.

Analysis of Variance↗
PubMedDate not supplied

In vitro repair of three-unit fiber-reinforced composite FPDs.

PURPOSE: Clinical damage, such as the fracture or abrasion of composite veneers, may cause the loss of a fixed partial denture (FPD). Intraoral methods may help in repairing and therefore lengthening the life span of the restoration. The aim of this in vitro study was to evaluate an intraoral method of repairing fractured FPDs made of two different fiber-reinforced composite framework systems. MATERIALS AND METHODS: Shear bond strengths of a composite between two different fiber-reinforced composite frameworks were determined after five different mechanical surface treatments. A silicate-silane coating intraoral air-abrading system provided the most reliable bond strength values and was therefore used for treatment for the following veneer repair. The repair of 24 three-unit posterior FPDs was performed using a restorative composite resin. All FPDs were examined after simulating clinical service using thermocycling and mechanical loading. Fracture forces were determined for original FPDs and for FPDs after simulated intraoral repair. RESULTS: The fracture strength of all original FPDs was about 900 N. After repair, a maximum decrease in strength of about 15% was determined. FPDs that were extremely damaged by cutting the framework showed the lowest results, with values of about 450 N. CONCLUSION: The repair of the fractured veneer of fiber-reinforced composite FPDs provided good results and therefore may lengthen the life span of damaged FPDs. The repair of the fractured frameworks showed good results but can only be recommended for limited temporary use.

Air Abrasion, Dental↗