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Biomedical subjects

M Belgun

Publications and source records attributed to M Belgun.

11 recordsLinked to original sources
PubMed1993

Effects of radioiodine therapy in hyperthyroidism (thyroid function, thyroid volume, Graves' ophtalmopathy, thyrotoxic heart disease).

The study group consisted of 135 hyperthyroid patients--128 with Graves' disease and 7 with toxic multinodular goiter. A single dose of radioiodine was given in 110 cases (81.48%), two doses in 22 patients (16.3%) and three doses in 3 patients (2.22%); mean total dose was 6.8 mCi (range = 3-24 mCi). The main goal of radio iodine therapy is to achieve euthyroidism; after radioiodine treatment, 61 patients (45.2%) were euthyroid, 60 patients (44.4%) with permanent hypothyroidism and 14 (10.36%) with PERSISTING HYPERTHYROIDISM--the mean duration of follow-up being 4.2 years. After radioiodine therapy, goiter became absent in 30 patients (28%); in those patients, goiter was moderately enlarged or large before therapy. Around 63% (12 cases) of the patients with thyrotoxic atrial fibrillation reverted to sinus rhythm. During the last four years (1990-1994) the patients with Graves' ophthalmopathy from the study group were treated with Prednisone after radioiodine therapy; this corticotherapy contributes to the lower percentage (1.5%) of worsening Graves' ophthalmopathy after radioiodine therapy.

Adult↗
PubMed1993

Effect of vitamin C administration on the ratio between the pro- and antioxidative factors.

Much evidence gathered in the last years involve the free radicals (FR) in the mechanisms of initiation, development of neoplastic transformations in vivo and in vitro, as well as in the activity of specific oncogenes. Most of it comes from the fact that the agents that remove the FR or interfere in the chain of events induced by FR can inhibit the neoplastic process both at cellular and molecular level. The antioxidant and free-radical scavenging activities of vitamin C have been intensely investigated, vitamin C being considered the most important antioxidant protective agent in the plasma. Our study is focused on the changes in lipid peroxides (MDA), free SH groups and the total antioxidative capacity in the plasma of 22 patients with differentiated thyroid cancer operated and treated with 131I, and then given 1 g vitamin C/day along one month. Blood samples were collected before 131I and then 4 days following 131I administration, and after 1 month of vitamin C administration per os. The following results were noted: (1) an increase of MDA concentration after 131I; (2) a decrease in the MDA level after one month of vitamin C administration; (3) an increase in the concentration of free SH groups after 131I; (4) a decrease in the level of free SH after vitamin C, and (5) a non-significant decrease in TAC after 131I and vitamin C. The results confirm the change in the balance between the oxidative and antioxidative factors under the effect of ionizing radiations and suggest the involvement of vitamin C as a protective and/or potentiating factor for the other antioxidative systems.

Adult↗
PubMed1993

Oxidative and antioxidative factors in the serum of thyroid cancer patients treated with 131I.

The variation of some parameters involved in maintaining the balance between pro- and anti-oxidative factors was followed-up in a group of patients thyroidectomized for folliculo-papillary, papillary and follicular cancer, before and after 5 days following the 131I administration. Radiotherapy led to the intensification of lipid peroxidation expressed by a significant increase in the malondialdehyde values. Among the parameters involved in the antioxidative process we noted an increase in both SH nonprotein groups and ceruloplasmin concentration. The total antioxidative capacity lowered significantly following irradiation, whereas uric acid remained unaltered.

Adult↗
PubMedDate not supplied

Use of angioscintigraphy in the diagnosis of malignant tumors of the liver.

Dynamic hepatic angioscintigraphy, a method of estimation and follow up of the double (arterial and portal) circulation in the liver, was performed in association with static liver scanning in 20 patients with suspicion of primary or secondary tumors of the liver, and in 5 healthy controls, after administration of 113min colloid. This procedure allowed confirmation of primary neoplastic tumors of the liver in 3 patients and of hepatic metastases in 5. The method supplies additional diagnostic information in malignant tumors of the liver and reduces the irradiation of the patients by using a single radiopreparation.

Hepatic Artery↗
PubMedDate not supplied

Results of 131I therapy in hyperthyroidism at 7-18 years of age.

Twenty-seven patients aged 7-18 years, with hyperthyroidism and diffuse goite received 131I and 125I in doses of 200-350 muCi/gm of gland. The drug was given in a unique dose to 14 patients and fractioned (maximum 4 doses) to the rest. The total maximum dose was 15 mCi. Doubtless recovery was obtained in 25 cases and probable improvement in another 2 (the patients were lost track of). Exophthalmometric values did not increase in any of the patients and in 2 cases of edematous exophthalmos the protrusion and edema disappeared after this treatment. Clear improvement in the nutritional state occurred and puberty followed a normal course. The incidence of both early and late transient hypothyroidism was 1/25, while permanent hypothyroidism occurred in 5/25. In 5 cases administration of 125I in doses of 500 muCi/gm of gland was not effective and necessitated 131I readministration. It was concluded that radioactive iodine (131 isotope) is an effective radiopharmaceutical for radical treatment of hyperthyroidism in children and adolescents. The therapeutical innocuity of 131I was perfect and the dose of 200-350 muCi/gm of gland was the most adequate. A follow-up of the functional status is however advocated in these patients for detection of late hypothyroidism.

Adolescent↗