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M Belleville

Publications and source records attributed to M Belleville.

7 recordsLinked to original sources

Electrical impedance brain scanner: principles and preliminary results of simulation.

In previous studies, the authors have shown the importance of impedance recording by stereotactic procedures for brain tumor detection. In this study they report the principles and the first results of an attempt to obtain the impedance value of any given point inside the brain by an external way. The experimental device is mainly made of a set of 128 electrodes, surrounded by an electrode guarding monitored by an operational amplifier the purpose of which is to made the electric field uniform and to enable a focused measure of the impedance by each of the 128 electrodes. The effect of this electrode guarding is demonstrated, and the present sensitivity of the prototype is shown on various obstacles. conductive or non-conductive; the influence of an impedance barrier on this sensitivity is the project of an impedometric scanner is described, and the problems due to the non-linear propagation of electric currents and to the anisotropic properties of the brain tissue are evaluated.

Brain↗

Plasma levels, elimination and metabolic fate of 4a-amino-8-chloro-2-methyl-1,2,3,4,4a,10a-hexahydro-10H-benzopyrano[3,2-c]pyridin-10-ylacetic acid lactam, a new antidepressive agent, in rats and dogs.

After single intravenous administration to dogs, 4a-amino-8-chloro-2-methyl-1,2,3,4,4a,10a-hexahydro-10H-benzopyrano[3,2-c]pyridin-10-ylacetic acid lactam (LM 1404) was rapidly distributed. Elimination from plasma was biphasic and dose-independent between 1 and 10 mg/kg, with a half-life for the beta-phase of 4.5 hr. After oral administration, LM 1404 was quickly and nearly completely absorbed. In rats, LM 1404 was rapidly absorbed and eliminated from plasma with a terminal half-life of 2.5 hr. The N-demethylated metabolite (LM 1580), which has a pharmacological activity nearly identical to that of LM 1404, was very abundant in plasma of both species, with half-lives of 13 hr in dogs and 3.5 hr in rats and areas under the curves respectively 2 and 4 times that of LM 1404. Urinary excretion was extensive; unchanged drug amounted to 7 and 1.5% and LM 1580 to 70% in dogs and rats.

Animals↗