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Biomedical subjects

M Belmonte

Publications and source records attributed to M Belmonte.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

Improved control in diabetes with continuous subcutaneous insulin infusion.

Nine insulin-dependent diabetic patients were treated with continuous subcutaneous (s.c.) insulin infusion, using a portable battery-driven infusion pump and home monitoring of capillary blood glucose. The infusions were maintained for 4 days during an acute in-hospital study and for up to 150 days on ambulatory patients. No significant changes in growth hormone and cortisol secretory patterns were found at the end of the acute study. Mean plasma glucose, M values, and glycosylated hemoglobin A1 (HbA1), as well as the patients' sense of well-being, improved significantly. However, absolute normalization of metabolic control was not achieved, since patients presented occasional, albeit minor, swings of blood glucose. The possibility that the same improvement in control could be achieved with multiple s.c. injections of insulin and similar monitoring of blood glucose in the home is discussed. It remains to be seen whether the degree of control obtained will influence the development of the late complications of diabetes mellitus.

Adolescent↗
PubMedDate not supplied

Combined continuous subcutaneous insulin infusion and multiple subcutaneous injections in type I diabetic patients.

Seven insulin-dependent diabetic patients (aged 16-34 yr) were treated for 10 mo with a combination of continuous subcutaneous insulin infusion (CSII) during the night and premeal boluses of insulin during the day. The technology and strategy of the system are discussed. Three of these patients had been on CSII for 1 yr before the start of this study. Mean fasting (126 +/- 44 mg/dl), mean preprandial blood glucose (131 +/- 54 mg/dl), and mean postprandial blood glucose (216 +/- 73 mg/dl) before starting this treatment fell to 86 +/- 12 mg/dl, 83 +/- 19 mg/dl, and 132 +/- 17 mg/dl, respectively, after 1 mo of treatment. Glycosylated hemoglobin (10.8 +/- 2.9% before the study) reached normal values (7.8 +/- 0.6%) after 2 mo of treatment. Improvement of glycemic control may be achieved with this form of insulin administration, which is of immediate practical application, until an ideal system of insulin delivery becomes available. This technique provides the conditions for testing the hypothesis that near normalization of glycemic control prevents or minimizes the degenerative complications associated with diabetes mellitus.

Adolescent↗
PubMedDate not supplied

Multiple daily self-glucose monitoring: its essential role in long-term glucose control in insulin-dependent diabetic patients treated with pump and multiple subcutaneous injections.

Twenty-one insulin-dependent diabetic patients, previously treated with continuous subcutaneous insulin infusion (CSII), multiple subcutaneous insulin injections (MSI), and a combination of CSII and MSI (combined CSII-MSI) all supported by frequent capillary self-blood glucose (CBG) determinations (5-7 times daily) participated in a program to assess the importance of frequent CBG monitoring. We used a crossover design where diabetic control as measured by mean blood glucose and glycosylated hemoglobin were compared during periods of frequent and infrequent capillary blood glucose monitoring. Diabetic control was significantly better during periods of frequent self-glucose monitoring. We conclude that in compliant, motivated young adults with insulin-dependent diabetes, frequent self-glucose monitoring is critical for the long-term maintenance of glycemic control.

Adolescent↗
PubMedDate not supplied

Evaluation of two methods of self blood glucose monitoring by trained insulin-dependent diabetic adolescents outside the hospital.

We studied the accuracy of the Chemstrip bG and Glucometer systems in the self-monitoring of blood glucose by trained adolescents. The determinations were done at home with simultaneous collection of whole blood into capillary tubes (Sarstedt) which were later analyzed by a glucose-oxidase analyzer (Beckman Instruments). In both cases, there was an excellent correlation between laboratory concentrations and Chemstrip bG (r = 0.96, P less than 0.001) and Glucometer (r = 0.96, P less than 0.001). Comparisons made at 8 mo remained with the same degree of accuracy. There was a trend toward greater deviation with higher plasma glucose values. Well-trained patients can achieve sufficient accuracy to permit the use of either of the methods tested with similar results.

Adolescent↗
PubMedDate not supplied

[Systems of biomedical information on the internet: bibliographic contents and electronic magazines].

OBJECTIVE: In this article we review two of the main Internet information services for seeking references to bibliography and journals, and the electronic publications on the Internet, with particular emphasis on those related to neurosciencs. DEVELOPMENT: The main indices of bibliography are: 1. MEDLINE. By definition, this is the bibliography database. It is an 'on line' version of the magazine with a smaller format, published weekly with the title pages and summaries of most of the biomedical journals. It is based on the Index Medicus, a bibliographic index (on paper) which annually collects references to the most important biomedical journals. 2. EMBASE (Excerpta Medica). It is a direct competitor to MEDLINE, although it has the disadvantage of lack of government subsidies and is privately financed only. This bibliographic database, produced by the publishers Elsevier of Holland, covers approximately 3,500 biomedical journals from 110 countries, and is particularly useful for articles on drugs and toxicology. 3. Current Contents. It publishes the index Current Contents, a classic in this field, much appreciated by scientists in all areas: medicine, social, technology, arts and humanities. At present, it is available in an on line version known as CCC (Current Contents Connect), accessible through the web, but only to subscribers. CONCLUSIONS: There is a growing tendency towards the publication of biomedical journals on the Internet. Its full development, if correctly carried out, will mean the opportunity to have the best information available and will result in great benefit to all those who are already using new information technology.

Databases, Bibliographic↗