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Biomedical subjects

M Bender

Publications and source records attributed to M Bender.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Rett syndrome].

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Ammonia↗
PubMed1983

[Transluminal coronary dilatation].

Percutaneous transluminal coronary angioplasty (PTCA) represents in patients with single-vessel disease the treatment of choice. Under adequate precautions the method can be performed with reasonable risk outside of a hospital with cardiac surgical operating rooms.

Angioplasty, Balloon↗
PubMed1983

Identification of three distinct papillomavirus genomes in a single patient with epidermodysplasia verruciformis.

Benign papillomas from a patient with a family history of epidermodysplasia verruciformis were examined for the presence of human papillomavirus (HPV) DNA. Employing stringent hybridization conditions that allow identification of a single type of HPV and radioactively labeled HPV-5 DNA as a probe, we have detected HPV DNA exhibiting sequence homology to HPV-5 in these tumors. Restriction endonuclease analysis of this HPV DNA confirmed its identity as HPV type 5. However, when hybridization was performed under less stringent conditions that allow all of the known types of HPV to react with the radioactively labeled HPV-5 DNA probe, two additional species of HPV DNA unrelated to HPV-5 were identified. As these two HPV types do not hybridize with HPV 1, 2, 3, or 4 under stringent conditions, they appear unique and have, as yet, not been reported to be associated with patients exhibiting epidermodysplasia verruciformis. Thus we have observed three distinct HPV species in benign papillomas from a single patient. These observations have important implications when attempting to correlate the type of HPV present in the various wart disease syndromes that have been described to date and further suggest that extreme care must be taken when analyzing carcinomas, occupying similar anatomic sites and suspected to have arisen from papillomas, for HPV species.

Animals↗
PubMed1983

Characterization of two HPV-3 related papillomaviruses from common warts that are distinct clinically from flat warts or epidermodysplasia verruciformis.

We have recently identified two unusual human papillomavirus (HPV) isolates while engaged in an ongoing study of wart disease in meat handlers and veterinarians. The papillomas from which these two viruses were isolated clinically resembled verruca vulgaris rather than either flat warts or epidermodysplasia verruciformis (EV). These two previously uncharacterized HPVs were molecularly cloned and characterized with respect to known HPVs. The genomes of the two viruses exhibited dramatically different restriction endonuclease cleavage patterns but were found to have significant sequence homology to each other, as well as to HPV-3 and a new virus isolated from a patient with EV. Neither of the two new HPV isolates exhibit detectable sequence homology under stringent conditions of hybridization or share similar restriction endonuclease cleavage patterns with previously characterized HPV types 1,2,4,5,6b, or a previously isolated HPV from meat handlers.

Adolescent↗
PubMed1982

Detection of human papillomavirus DNA in anogenital neoplasias.

The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has been detected in epithelial-derived cancers, both cutaneous and metastatic, from patients exhibiting the rare, chronic flat wart disease, epidermodysplasia verruciformis (EV). Except for patients exhibiting this chronic wart syndrome, the association of HPV genomes with human epithelial cancers has not been demonstrated. In an attempt to delineate the association and possible involvement of papillomaviruses with human anogenital carcinomas, we have begun an analysis of these cancers for the presence of HPV-specific nucleotide sequences by using highly sensitive hybridization procedures capable of detecting distantly related papillomaviruses at low copy number. Here we demonstrate the presence of HPV DNA in several types of anogenital tumours: Bowenoid papulosis, carcinoma in situ, and verrucous carcinoma. These data indicate that HPV can be detected in several types of premalignant and malignant tumours, supporting the contention that this group of viruses may be involved in the development of certain types of human epithelial-derived cancers.

Adult↗
PubMed1982

Status of interagency cooperation between interdisciplinary clinics or hospitals and the public schools.

Since public schools are now mandated to provide a large and varied range of clinical services to handicapped school children, a survey was conducted of 26 interdisciplinary UAF clinics and hospitals in regard to the types of services which they offer to public school children and the extent in which coordination of such services has been developed. Results suggest that diagnosis of evaluation is the primary reason for referral but that a wide variety of community outreach services are both requested by the schools and offered by interdisciplinary hospital and clinic staff. These services are described and the implications for future interagency cooperation are discussed.

Child↗
PubMed1982

Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis.

DNA extracted from squamous cell carcinomas from patients with the chronic wart disease syndrome, epidermodysplasia verruciformis, was analyzed for the presence of human papillomavirus (HPV)-specific DNA sequences by Southern blot hybridization analysis. Employing an HPV probe obtained by molecular cloning of viral DNA purified from benign warts from these patients, we have unequivocally identified HPV-specific nucleotide sequences in squamous cell carcinomas from these patients. Restriction endonuclease mapping indicated that the DNA present in the carcinomas was of the same type (type 5) as that found in the benign tumors from these patients and was present as unintegrated, free viral DNA. Moreover, we have demonstrated the presence of HPV-5 DNA in a subcutaneous metastatic tumor from one of these patients. This latter observation essentially eliminates the possibility that the HPV-5 DNA present in the malignant tumors in these patients resulted from cross-contamination from an adjacent benign warty lesion. In addition to wild-type HPV-5 DNA, both the primary and metastatic carcinomas analyzed also contained an HPV-5 DNA species lacking approximately 20% of the HPV-5 DNA genome. These subgenomic forms of HPV-5 DNA could not be detected in benign papillomas from these patients.

Carcinoma, Squamous Cell↗
PubMed1980

Identifying children with school learning and behavior problems served by interdisciplinary clinics and hospitals.

Questionnaires were sent to interdisciplinary UAF programs across the country to assess the types of handicapped school children who were receiving services at their facilities. A return rate of 65 percent was obtained and the total sample of children was 2088. Results indicated that a wide variety of ages and handicapping conditions were reported. Referral sources and services rendered were analyzed, and implications for cooperation with public school personnel were discussed.

Adolescent↗
PubMed1980

Design considerations for fume hoods for process plants.

Proper design of fume hoods is a necessary requisite for a clean working environment for many industrial processes. Until recently, the design of these hoods has been rather a trial and error approach and not based on sound engineering design principles. Hatch Associates have developed and applied new techniques to establish hood parameters for different industrail processes. The paper reviews the developed techniques and illustrates practical application of these techniques to the solving of difficult and comples fume hood design and operating performance problems. The scope of the paper covers the following subject areas: definitions and general considerations: evaluation of volume and heat flow rates for emission sources; local capture of process emissions; remote capture of process emissions and case studies of fume hood applications. The purpose of the paper is to detail a coherent approach in the analysis of emission problems which will result in the development of an efficient design of a fume capture hood. An efficient fume hood can provide a safe working place as well as a clean external environment. Although the techniques can be applied to smaller sources, the case studies which will be examined will be for fume hoods in the flow design range of 50 000 CFM to +1 000 000 CFM.

Air Pollutants↗
PubMed1980

Dyslexia: initial assessment and outcome.

The initial multidisciplinary evaluations on 40 dyslexic children were reviewed in an attempt to identify factors which might favor a positive outcome from educational remediation. The children manifested a high incidence of dysarticulation, impaired auditory discrimination and visual motor perceptual delays. All of the subjects exhibited progress at a constant rate (reading quotient) while enrolled in a full-time remedial program for dyslexic children. Factors predictive of significant improvements could not be identified. The hypothesis that brighter dyslexic children improve more in a remedial setting was not supported. Initial mathematics quotients, however, were higher and demonstrated more improvement than initial reading quotients in all groups. Implications for educational policy and pediatric practice are discussed.

Auditory Perception↗
PubMed1979

Fume hoods, open canopy type--their ability to capture pollutants in various environments.

Using field observations, modelling techniques and theoretical analysis, parameters describing the performance and collection efficiency of large industrial canopy fume hoods are established for, a) steady state collection of fume and b) collection of plumes with fluctuating flowrates. Hopper and pool type hoods are investigated. A baffle plate arrangement for placement within hoods is proposed. It prevents recirculation and spillage of fume. Temporary storage of fume surges within the hood is shown to be possible. At a cost of $6 per m3/hr ($10 per ft3/min) of installed fume control system capacity the arrangement promises to save millions of dollars on large new installations and to significantly improve the collection efficiency of many existing systems. A practical application of the results is proposed for the design of electric arc furnace canopy hoods.

Air Pollutants↗
PubMed1976

Effect of p-chlorophenylalanine (PCPA) on pituitary hormones and testosterone in the human.

L-p-Chlorophenylalanine (L-PCPA) was given in a dosage of 1.5 g daily, to 6 healthy male subjects over a period of 12 days. No effect on plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH), thyroid stimulating hormone (TSH), testosterone and other steroid hormones could be observed. These results are discussed in respect to the sexually stimulating effect of PCPA.

Adult↗