[Synthesis and tests of antibacterial activity of new analogs of d(+)-threo-1-(p-methylsulphonylphenyl)-2-dichloroacetamido-1,3-propanediol (thiamphenicol)].
The synthesis of three new analogues of D(+)-threo-1-(p.methylsulphonylphenyl)-2-dichloroacetamido-1,3-propanediol (thiamphenicol) (I) which are D(--)-threo-2-(p.toluensulfophonamido)-1-(p.methylsulphonylphenyl)-1,3-propanediol (II), D(--)-threo-2-(p.aminobenzensulphonamido)-1-(p.methylsulphonylphenyl)-1,3-propanediol (III), D(--)-threo-2-(p.acetamidobenzensulphonamido)-1-(p.methylsulphonylphenyl)-1,3-propandiol (IV) is reported. The antibacterial activity of the compounds obtained was estimated in comparison with (I) in vitro and the therapeutic activity in vivo by experimental infection of the rat. The results showed the total absence of both types of activity.
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