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M Bethouart

Publications and source records attributed to M Bethouart.

11 recordsLinked to original sources
PubMed1992

[Experimental histological study of the local toxicity of intra-tubal injections of methotrexate].

The injection of methotrexate is an alternative to laparoscopic surgical treatment of unruptured ectopic pregnancy. An experimental trial on rabbits was designed to evaluate this new approach. In situ injection of methotrexate does not cause either real tubal epithelial impairment, nor an adverse effect on treated rabbits' fertility. However, sub-peritoneal injections of methotrexate are responsible for a typical histological lesion. These results are discussed emphasising the importance of the way the administration is carried out.

Animals↗
PubMed1992

[Proximal tubal recanalization by endoluminal laser probe. I. Anatomic results in the female rat].

To evaluate the cicatrization of the uterine horn after the recanalization by endoluminal laser probe, 50 white female rats of Wistar's race have been separated into two groups. The group 1 (nb = 10) had for aim to validated the procedure of obstruction. In group 2 (nb = 40), we performed the recanalization six weeks after the obstruction. Histologic samples were obtained 48 hours, 3 weeks and 6 weeks after treatment. In group 1, we found a complete obstruction in 70% of the cases, and a tight stenosis in 30% of the cases. In group 2, at 48 hour's control after the treatment by laser, we found a drill hole with a blackened look without parietal sequel in 80% of the cases. At 6 week's control, we found a normal lumen with a regeneration of the epithelioma in 85% of the cases. For energy deposition under 30 Joules, we found good results in 95% of the cases. Above 30 Joules, we always found bad results (5 cases on 5).

Animals↗
PubMed1987

[Lasers in gynecological microsurgery. Comparative experimental study].

Forty Wistar female rats were the subject of a laser resection of the uterine horn with microsurgical anastomosis, comparing the effect of various available lasers with blade section. The animals were divided in four groups. The first group, with 10 animals, underwent a resection of each uterine horn, using the CO2 laser, with a one layer anastomosis using ethilon 10/10, under microscope. Five of them were examined one week later and the five others three weeks later, with evaluation of the adhesions, patency of the anastomosis and its histological examination. The three other groups underwent a resection using an Argon laser, Yag laser or scissors. With the Yag laser, the lumen disappeared completely and the mucosa as well as the musculosa were totally destroyed. In the other groups, adhesions were noted as well as a variable inflammatory reaction, in early and late evaluations. However, this reaction is minimal after a resection with scissors, moderate after CO2 laser, significant after Argon laser. It is concluded that only the CO2 laser is suitable for gynecological microsurgery; however, the only advantage over a scissor resection is a faster operating time and a better hemostasis; the other parameters are in favor of blade resection. Thus, it seems that laser resection is not an ideal procedure in humans, for tubal resection before anastomosis.

Animals↗
PubMed1983

[Effects of irradiation on vascular microsurgical sutures. Experimental study on 125 rats].

The effects of irradiation on microsurgical sutures following vascular surgical procedures were studied in 125 rats divided into 7 groups, animals in 5 groups being irradiated at different doses. Follow-up examinations were conducted a minimum of 6 months after suturing and 2 months after irradiation. Evaluations included precise histological study of each vascular specimen removed, arteriography, and scanning electron microscopy. Findings demonstrated that it is possible to obtain satisfactory early functional results after irradiation of microsurgical anastomoses, and that the relation in time between trauma produced by radiotherapy and surgery plays an important role.

Animals↗
PubMed1982

[Dopamine-secreting phaeochromocytoma. A little known clinical and biochemical entity (author's transl)].

The authors have observed a case of phaeochromocytoma revealed by fever and poor general condition without hypertension. Urinary catecholamine assays showed predominant dopamine secretion. Only 13 cases of dopamine-secreting phaeochromocytoma have been published so far, including 4 with clinical symptoms resembling those of this patient. The metabolic and hormonal effects of high plasma dopamine levels were studied, and responses similar to those observed with TRH stimulation by dopamine infusions were obtained: TSH and prolactin responses were inhibited, and GH was increased. This case underlines the need for catecholamine assays, including dopamine, in patients with unexplained fever and apparently non-secretory adrenal tumour.

Adrenal Gland Neoplasms↗
PubMed1980

[Tubal epithelium. Scanning electron microscopy in the menstrual cycle, in pregnancy and in the menopause (author's transl)].

The Fallopian tubes of 18 women who were either in reproductive age or were menopausal were studied by scanning electron microscopy. There were different cells seen in the epithelium. These were ciliated and non-ciliated cells, and cells, with a single cilium which was central and cells with short cilia. These elements undergo cyclical changes: secretory phenomena are at their maximum during the ovulatory phase. There is no sudden desquamation in tubal epithelium, nor is there massive deciliation. All the same, there are images that look like marguerites (described in the text) which are evidence of cellular regeneration. The appearance suggests a state of rest in precocious menopausal women and in pregnancy. The phenomena seen during the secretory phases disappear and the distribution of the cells is modified. Deciliation is found 20 to 30 years after the menopause. The physiological significance of these phenomena is still uncertain and their role in pathology has still to be defined.

Cilia↗
PubMed1975

[Atrio-ventricular block in Steinert's disease. Electrophysioligic and histologic study of the conduction system].

An anatomical study of the conducting pathways was carried out in a case of Steinert's disease complicated by a complete atrio-ventricular block with syncope. Electrical study of the potentials in the bundle of His located the block within and below the bundle. When the patient died, an anatomical study of the conducting pathways was carried out. There were foci of fibrosis mainly within the conducting system, but these changes were moderately marked only, and seemed to be the final stage of a disorder which was not itself visible optically. The basic underlying pathological process is probably biochemical, and the lesions seen microscopically are simply a late sign of the disorder.

Cardiomyopathies↗