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M Bevilacqua

Publications and source records attributed to M Bevilacqua.

150 records · Page 9Linked to original sources
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Dilated cardiomyopathy caused by acute myocarditis in pediatric patients: evolution of myocardial damage in a group of potential heart transplant candidates.

Dilated cardiomyopathy, frequently caused by acute myocarditis, is a common indication for heart transplantation in pediatric patients. The prognosis of children with acute myocarditis is not well known but is believed to be poor. We report the short-term follow-up in 20 pediatric patients (mean age 22 +/- 19 months) with acute myocarditis diagnosed by endomyocardial biopsy. All patients were treated by immunosuppression (cyclosporine and steroids). Endomyocardial biopsy was repeated after 6 months in all patients and after 1 year in patients with persistent acute myocarditis. To evaluate left ventricular function, two-dimensional echocardiography was performed at the time of each endomyocardial biopsy, and left ventricular end-diastolic volume index and ejection fraction were calculated. After 6 months, endomyocardial biopsy showed persistence of acute myocarditis in 13 of 20 patients. After 1 year, endomyocardial biopsy performed in 11 of 13 patients with persistent acute myocarditis showed ongoing acute myocarditis in 10 of 11 patients. On admission to the hospital, 16 of 20 patients had left ventricular dilation (end-diastolic volume index 122 +/- 19 ml/m2; normal values 63 +/- 17 ml/m2) and 20 of 20 had decreased contractility (ejection fraction 34% +/- 11%; normal values 66.1% +/- 5.2%). After 6 months, in all patients the end-diastolic volume index decreased to 73 +/- 23 ml/m2 (p < 0.001), and the ejection fraction increased to 56% +/- 8% (p < 0.000001).(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMedDate not supplied

Glucocorticoids and Th-1, Th-2 type cytokines in rheumatoid arthritis, osteoarthritis, asthma, atopic dermatitis and AIDS.

Endogenous or exogenous glucocorticoids play a key role in the control of the immune and inflammatory network. Regulation of the effects of the glucocorticoids depends on changes in therapeutic levels, but also, as recently discovered, on modifications of the binding characteristics of the glucocorticoid receptors of target cells. In rheumatoid arthritis (RA), chronic bronchial asthma, atopic dermatitis, in chondrocytes from osteoarthritic patients, and in advanced stages of HIV infection, there is a down-regulation of the glucocorticoid receptors. As a consequence, B cell immune proliferation is stimulated in RA, proteolysis is enhanced in osteoarthritis, the glucocorticoids' therapeutic effect is reduced in asthma and atopic dermatitis, and a chronic persistent increase of interferon alpha is seen in HIV. Finally, glucocorticoids are also capable of switching CD4 cells from a Th-1 to a Th-2 pattern. A decreased affinity of lymphocyte glucocorticoid receptors could hinder such a switch, with obvious clinical implications.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Pelvic floor dyssynergia: videoproctographic analysis and pathologic associations in defecation obstruction syndrome].

INTRODUCTION: Pelvic floor dyssynergia is included pathophysiologically in the functional dyschezia group. It is characterized by the paradoxical contraction or lack of relaxation of the puborectal muscle and/or external sphincter during defecation, with consequent functional outlet obstruction. The diagnosis is not always easy because there is no really specific test, nor any diagnostic gold standard; also, many pathophysiologic and epidemiologic findings are still unknown. We tried to define the diagnostic criteria of this condition with the statistical analysis of the main defecographic parameters and to assess the radiologic correlation between functional forms and "mixed" forms, that is those associated with other anorectal disorders. MATERIAL AND METHODS: We reviewed 121 videoproctographic examinations performed January, 1995, to December, 1996, in patients with clinical and instrumental signs suggestive of pelvic floor dyssynergia and compared the findings with those of a control group of 20 patients with no defecation disorders. We also assessed the frequency of the major anorectal disorders associated with pelvic floor dyssynergia relative to the pure form. RESULTS: Initiation time (11 s versus 1 s; p < .05), evacuation time (47 s versus 10 s; p < .01) and the rate of residual contrast material (57 versus 7) were on average greater in dyssynergia patients. These parameters provide important information on the degree and rapidity of rectal voiding. 81% of our dyssynergia patients had rectal voiding time > 30 s, with final residual contrast material 1/3 to 2/3 of the initial volume. Posterior anorectal angle measurements showed significant differences on strain and evacuation and in anorectal angle excursion at rest/on evacuation (4 +/- 17 degrees; p < .01). Anorectal angle excursion < 15 degrees or its paradoxical reduction was associated with anal diameter < 12 mm during voiding in 85% of cases. We subdivided our population into 4 groups: group A (15 patients: median age: 38 +/- 14 years) with dyssynergia only: group B (22 patients; median age: 54 +/- 23 years) with dyssynergia associated with a functional megarectum); group C (66 patients; median age: 52 +/- 14 years) with mixed pathophysiological patterns such as megarectum, rectocele, intrarectal intussusception, mucosal prolapse and perineal descent; group D (18 patients; median age: 52 +/- 16 years) with the same characteristics as in group C but also with hemorrhoids and anal fissures. DISCUSSION AND CONCLUSIONS: At first (digital radiography) and second level (videoproctography), the diagnosis of pelvic floor dyssynergia is based manly on dynamic parameters (initiation and evacuation times) correlated with the residual contrast agent volume. At baseline, the diagnosis is based on the reduced/no excursion of the anorectal angle between rest and evacuation, together with a narrowed anal eanal. The rate of pure pelvic floor dyssynergia was lower (12.4%) than that of the pathophysiologically mixed patterns and the median age of this group of patients was 38 +/- 14 years, which is statistically lower than that of the other groups (52 +/- 14). Comparing the frequency of purely functional forms in the age range < 40 years, we observed a statistically significant difference (p < .001), which suggests that this disorder is always the first cause of the outlet obstruction syndrome.

Adolescent↗