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Biomedical subjects

M Bhamra

Publications and source records attributed to M Bhamra.

11 recordsLinked to original sources
PubMed1993

Targeting of microdiscs in white cells to tibial abscesses in rabbits.

The ability to deliver drugs to specific foci of infection is a sought-after goal. One solution is to use microparticles as drug carriers. This approach is limited by detection of microparticles by the reticuloendothelial system (RES). In order to reduce RES uptake of such particles, we investigated the possibility of "hiding" microparticles within white cells prior to targeting them to experimental tibial abscesses. We used radioactive silicone microdiscs, supplied by the Royal Signals & Radar Establishment. Twelve rabbits with abscesses in the right tibia were used: six control animals received radioactive opsonised microdiscs intravenously, and six animals received the same dose of microdiscs following incubation of the microdiscs with white cells. Each animal's liver, spleen, lungs, and both tibiae were removed, weighed, and homogenised. Radioactivity counts were obtained from each tissue, and the ratio of counts per gram of tissue for the right/left tibiae was calculated for the two groups of animals. The ratio of counts in the control group was 1.66 (+/- 0.57 SD), and the mean ratio of counts from the rabbits who had microdisc incubated with white cells was 3.32 (+/- 0.52 SD). This difference was statistically significant at p = 0.02 (Mann-Whitney U test).

Abscess↗
PubMed1991

Microtia and short stature: a new syndrome.

Bilateral microtia, absent patellae, short stature, poor weight gain, and characteristic facial features are described in two female sibs. Other skeletal anomalies included complete habitual dislocation of the elbow, slender ribs and long bones, abnormal modelling of the glenoid fossae with hooked clavicles, and clinodactyly. Bone age was significantly delayed and there was flattening of the epiphyses. This unusual combination of features has many similarities to the syndrome described by Hurst et al.

Abnormalities, Multiple↗
PubMed1991

Delayed sciatic nerve palsy following total hip arthroplasty.

Peripheral neuropathy, following total hip arthroplasty, has a reported incidence of 0.7%. However, delayed sciatic nerve palsy has only been reported twice in the literature. We report on two further cases, both of whom developed clinical sciatic nerve palsy at 72 hours after surgery.

Aged↗
PubMed1989

Morphology of the femur in proximal femoral fractures.

We studied the morphology of the contralateral femur in 10 patients with subcapital fractures, 10 with trochanteric fractures and 10 with unilateral osteoarthritis. We found that the patients with trochanteric fractures had a significantly shorter femoral neck (4.5 +/- 0.5 cm) than patients with subcapital fractures or osteoarthritis (5.4 +/- 0.4 cm). It may be that this difference in femoral neck length is related to the site at which a proximal femoral fracture occurs.

Aged↗
PubMed1989

Axillary aneurysm after shoulder injury. A report of 2 cases.

Two cases of false aneurysm of the axillary artery occurred after closed shoulder injuries. One was a dislocation of the shoulder, and the other was a fracture of the lesser tuberosity. In both cases the diagnosis was delayed, and only became apparent after excessive bruising was seen.

Aged↗
PubMed1989

To stitch or not to stitch the fat?

A total of 22 patients having hip replacements were studied to determine biochemically whether or not fat stitches cause fat necrosis. We found that fat necrosis, as measured by the triglyceride concentration of the drainage fluid, occurred in all wounds. The use of a fat stitch did not increase the amount of fat necrosis, but significantly reduced the amount of fluid drained (P less than 0.001; Student's t test). This retention of triglycerides is probably undesirable as they can act as a substrate for prostaglandin synthesis.

Adipose Tissue↗
PubMed1989

Coracoid process transfer for acromioclavicular dislocations. A report of 20 cases.

Twenty patients with acromioclavicular dislocations treated by transfer of the coracoid process to the clavicle were reviewed and were compared to a previous study. Surgery was performed for acute dislocations in seven cases and for chronic dislocations in 13 cases. At the follow-up examination (5.6 +/- 3.5 years for acute and 4.0 +/- 3.6 years for chronic dislocations), all patients had some relief of their symptoms. Nine patients had residual aching in the joint, and this was associated with an older age at injury (40 years as opposed to 25 years for chronic dislocations). Complications included superficial wound infections in two patients, transient stiffness of the shoulder in two patients, loss of range of movement in one patient, and subjective weakness in one patient. In general, satisfactory results were achieved in younger patients, but as the results of conservative treatment of these injuries are comparable, the operation is indicated only in patients with symptomatic chronic acromioclavicular dislocations.

Acromioclavicular Joint↗