Biomedical subjects

M Bhaskar

Publications and source records attributed to M Bhaskar.

20 records · Page 2Linked to original sources

PubMedDate not supplied

The role of cadmium in induction of atherosclerosis in rabbits.

Experiments were carried out in rabbits to determine the effects of prolonged treatment of cadmium (8 mg/kg/day) for a period of 6 months on histopathological changes and biochemical alterations of lipid profiles in various tissues compared to normal rabbits. No ECG changes were observed before and at the end of cadmium treatment. Histopathological studies of the coronary artery revealed atherosclerotic changes. Total lipids, cholesterol, free fatty acids and phospholipids were significantly increased in heart and kidney, but decreased in serum and liver. Triglyceride content was increased significantly in heart and kidney with a significant depletion in liver and serum. It is postulated that atherosclerotic changes in rabbits probably occurred through toxic effects of cadmium but the exact mechanism needs to be elucidated.

Animals↗

PubMedDate not supplied

Skeletal muscle carbohydrate metabolism during short-term and prolonged in vivo electrical stimulations.

Electrical stimulations were applied to the gastrocnemius muscle of intact frog. Rana hexadactyla (Lesson) for short-term (SMS) and prolonged (PMS) periods. Short-term muscular stimulations resulted in decreased glycogenolysis and glycolysis with depleted glycogen and lactic acid contents in the muscles and increased lactic acid content in the blood. The activity levels of SDH and MDH were decreased in SMS muscles. Prolonged muscular stimulations, on the other hand, increased glycogenolysis and glycogenolysis was suggested to be due to stepped-up glycogenesis. Tissue oxidative metabolism was also correlated with regulation of activities of enzymes concerned with anaerobic pathways.

Animals↗