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Biomedical subjects

M Bhatnagar

Publications and source records attributed to M Bhatnagar.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Tuberculous chylous ascites: pathognomonic CT findings.

The computed tomographic (CT) appearance of chylous ascites is usually that of water with corresponding attenuation coefficients. This case report depicts the fat-fluid level sign on CT (shown by supine and decubitus scans), which is pathognomonic of chylous ascites.

Adult↗
PubMedDate not supplied

Neurochemical changes in the hippocampus of the brown Norway rat during aging.

Microdensitometrical and stereological techniques were applied to study the effects of aging on the hippocampus of 3-, 6-, 12-, 18-, 24-, 30-, and 36-month-old male Brown Norway rats. Stereological analysis of basic fibroblast growth factor (bFGF) immunoreactive glial cells in the CA1 area showed an age-dependent decrease in the number of cells, starting at 18 months of age. Specific mean gray values of the immunoreactivity for bFGF were reduced in the CA3 area, in the dentate gyrus, and in fields of the CA1 area, starting at 24 months of age. There were no differences between the age groups in the number of glial fibrillary acidic protein or glucocorticoid receptor (GR) immunoreactive cells of the CA1-CA2 areas. However, the intensity of the GR immunoreactivity was decreased in the 18-month-old and older rats. No changes in the immunoreactivity for the mineralocorticoid receptor were observed in the CA1-CA2 areas of any of the age groups. Spontaneous alternation test and reactivity in an open field did not reveal marked differences between the age groups. These findings give evidence that there is a loss of neural GR immunoreactivity, but no loss of GR immunoreactive neurons, in the CA1-CA2 areas of the aged Brown Norway rat. Aging may also be characterized by substantial deficits of glially derived growth factors, such as bFGF in the hippocampus. The changes in immunoreactivities were not correlated to alterations in selected behaviors dependent on normal hippocampal function.

Aging↗
PubMedDate not supplied

Pediatric atlantoaxial instability presenting as cerebral and cerebellar infarcts.

Atlantoaxial instability can lead to severe, permanent neurologic compromise and death if not treated by cervical fusion. However, identification of atlantoaxial subluxation can be difficult owing to the often confusing signs and symptoms. We describe a patient with unexplained transient repeated cerebral and cerebellar signs who had 10 mm of translation of the atlas on the axis owing to os odontoideum with infarcts in the cerebellum and occipital parietal lobes. These correlated with angiographically documented vertebral artery narrowing at the level of the axis and the subsequent low flow to the posterior cerebellum. After stabilization and fusion of the cervical spine, the patient regained normal neurologic function and has remained symptom-free at 2 years of follow-up.

Atlanto-Axial Joint↗
PubMedDate not supplied

Comparison of carcinoembryonic antigen in tissue and serum with grade and stage of colon cancer.

BACKGROUND: Serial plasma carcinoembryonic antigen (CEA) levels are routinely used to detect postoperative recurrence of colon cancers. However, levels of intrinsic CEA production by individual tumors, which might be helpful for interpreting serum CEA levels, are not routinely available. MATERIALS AND METHODS: CEA levels were determined in twenty tissue biopsy specimens of colon carcinoma and sixteen normal colonic tissue specimens from India, by immunohistochemistry (IH) and by quantitative enzyme immunoassay (EIA). Serum samples from 62 colon cancer patients and 25 healthy blood donors were analyzed for CEA by EIA. RESULTS: Tissue CEA levels were highest for well differentiated adenocarcinomas (5.2-37 micrograms/g protein) with progressively lower levels seen in moderately differentiated and poorly differentiated tumors, and in normals. The intensity of immunostaining paralleled the levels determined quantitatively. Mean serum CEA levels were 1.5 ng/ml for normals and 4.2, 6.4, 23, and 102 ng/ml for Dukes' A, B, C and D stage tumors, respectively. CONCLUSION: Preoperative serum CEA levels do not, in themselves, take into account differences in CEA production between individual tumors. Determination of tumor CEA content by quantitative or immunohistochemical methods, could be a useful adjunct for the clinical management of colon carcinoma, by improving interpretation of serum CEA levels.

Adenocarcinoma↗
PubMedDate not supplied

Prevalence of anaemia among adolescent girls in rural area of District Meerut, U.P.

The prevalence of anaemia in 504 adolescent girls (10-18 yrs) representing 24 subcentre villages of Daurala block of Meerut was 34.5%. The prevalence of mild, moderate and severe anaemia among adolescent girls was 19.0%, 14.0% and 1.4% respectively. Majority (55.2%) were having mild anaemia and only 4.0% had severe anaemia. Anaemia was found to be significantly associated with educational status (P < 0.05), birth order (P < 0.05), awareness regarding anaemia (P < 0.05) and marital & obstetric status (P < 0.05) with no association with age, anthropometry and menarcheal age (P > 0.05).

Adolescent↗
PubMedDate not supplied

Morbidity pattern of communicable diseases in an urban area of Uttar Pradesh.

The period prevalence rate of communicable diseases in Uttar Pradesh, India, in the present study was found to be 119.7 per thousand population. There were 1.08 communicable diseases per morbid person. The leading cause of morbidity was ascariasis (24.1 per 1000). The morbidity was significantly higher in young persons (below 14 years of age) and in those without spouse. The social class and educational status were found to have negative association with the morbidity. However, the sex did not show any influence on the morbidity.

Age Factors↗
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Calcium channel blockers and terbutaline--a positive interaction.

The role of two calcium channel blockers, nifedipine and verapamil was investigated in patients of bronchial asthma. Both the drugs given orally produced an insignificant rise in PEFR, FEF25-75% and FEV1. Given along with terbutaline, however, these drugs produced significantly greater increase in PEFR, FEF25-75% and FEV1 as compared to patients receiving terbutaline alone. The two calcium channel blockers also inhibited the terbutaline induced tremors and palpitation.

Adult↗
PubMedDate not supplied

Effects of acute amphetamine treatment on the butyrylcholinesterase activity in adrenal glands of mice.

Butyrylcholinesterase (BChE, EC 3.1.1.8.) activity in adrenal cortex and medulla was studied in control mice and in mice treated with DL-amphetamine. Amphetamine 6 mg/kg body weight, enhanced the enzyme activity in the adrenal medulla. In cortical layers, the effect was different for various layers; the enzyme activity decreased in the zona glomerulosa and in the zona reticularis, but remained unaltered in the zona fasciculata. In view of various neuronal and nonneuronal functions of BChE, it is suggested that the difference in effect of amphetamine on activity of BChE in various parts of glands is due to the neuronal and nonneuronal origin and function of the adrenal medulla and the cortex.

Adrenal Cortex↗